Search Results - "STOCKLEY, P. G"

Comparing antiviral strategies against COVID-19 via multiscale within-host modelling by Fatehi, F, Bingham, R J, Dykeman, E C, Stockley, P G, Twarock, R

“…Within-host models of COVID-19 infection dynamics enable the merits of different forms of antiviral therapy to be assessed in individual patients. A stochastic…”
Get full text

Identification of novel RNA secondary structures within the hepatitis C virus genome reveals a cooperative involvement in genome packaging by Stewart, H., Bingham, R.J., White, S. J., Dykeman, E. C., Zothner, C., Tuplin, A. K., Stockley, P. G., Twarock, R., Harris, M.

“…The specific packaging of the hepatitis C virus (HCV) genome is hypothesised to be driven by Core-RNA interactions. To identify the regions of the viral genome…”
Get full text

Fabrication and characterization of gold nano-wires templated on virus-like arrays of tobacco mosaic virus coat proteins by Wnęk, M, Górzny, M L, Ward, M B, Wälti, C, Davies, A G, Brydson, R, Evans, S D, Stockley, P G

“…The rod-shaped plant virus tobacco mosaic virus (TMV) is widely used as a nano-fabrication template, and chimeric peptide expression on its major coat protein…”
Get more information

Generation of neutralizing aptamers against herpes simplex virus type 2: potential components of multivalent microbicides by MOORE, M. D, BUNKA, D. H. J, FORZAN, M, SPEAR, P. G, STOCKLEY, P. G, MCGOWAN, I, JAMES, W

“…The prophylactic use of topical antiviral agents has recently been validated by the reduction in human immunodeficiency virus (HIV) type 1 infection incidence…”
Get full text

Dynamic Allostery Controls Coat Protein Conformer Switching during MS2 Phage Assembly by Dykeman, E.C., Stockley, P.G., Twarock, R.

“…Previously, an RNA stem–loop (TR) encompassing 19 nt of the genome of bacteriophage MS2 was shown to act as an allosteric effector of conformational switching…”
Get full text

Simple Rules for Efficient Assembly Predict the Layout of a Packaged Viral RNA by Dykeman, E.C., Grayson, N.E., Toropova, K., Ranson, N.A., Stockley, P.G., Twarock, R.

“…Single-stranded RNA (ssRNA) viruses, which include major human pathogens, package their genomes as they assemble their capsids. We show here that the…”
Get full text

Multiple presentation of foreign peptides on the surface of an RNA-free spherical bacteriophage capsid by Mastico, Robert A, Talbot, Simon J, Stockley, Peter G

“…Department of Genetics, University of Leeds, Leeds LS2 9JT, U.K. We have produced a plasmid expression vector for the coat protein of RNA bacteriophage MS2…”
Get full text

Identification of a High-Affinity RNA-Binding Site for the Human Immunodeficiency Virus Type 1 Rev Protein by Tiley, Laurence S., Malim, Michael H., Tewary, Hamant K., Stockley, Peter G., Cullen, Bryan R.

“…Expression of the structural proteins of human immunodeficiency virus type 1 requires the direct interaction of multiple copies of the viral Rev protein with…”
Get full text

Purification and initial characterization of AhrC: the regulator of arginine metabolism genes in Bacillus subtilis by Czaplewski, L G, North, A K, Smith, M C, Baumberg, S, Stockley, P G

“…The arginine-dependent repressor-activator from Bacillus subtilis, AhrC, has been overexpressed in Escherichia coli and purified to homogeneity. AhrC,…”
Get more information

Effects of amino acid substitution on the thermal stability of MS2 capsids lacking genomic RNA by Stonehouse, N.J., Stockley, P.G.

“…The thermal stability of capsids of the bacteriophage MS2, lacking genomic RNA, has been investigated using electron microscopy. Coat protein mutants with…”
Get full text

The roles of the conserved pyrimidine bases in hammerhead ribozyme catalysis: evidence for a magnesium ion-binding site by Murray, J B, Adams, C J, Arnold, J R, Stockley, P G

“…We report details of the synthesis and characterization of oligoribonucleotides containing 4-thiouridine or 2-pyrimidinone ribonucleoside (4HC). We have used…”
Get full text

Structure and assembly of turnip crinkle virus. II. Mechanism of reassembly in vitro by Sorger, P K, Stockley, P G, Harrison, S C

“…Dissociation of turnip crinkle virus (TCV) at elevated pH and ionic strength produces free dimers of the coat protein and a ribonucleoprotein complex that…”
Get more information

Crystal structure of an RNA bacteriophage coat protein-operator complex by Valegård, Karin, Murray, James B, Stockley, Peter G, Stonehouse, Nicola J, Liljas, Lars

“…The RNA bacteriophage MS2 is a convenient model system for the study of protein-RNA interactions. The MS2 coat protein achieves control of two distinct…”
Get full text

Use of synthetic oligoribonucleotides to probe RNA - protein interactions in the MS2 translational operator complex by TALBOT, S. J, GOODMAN, S, BATES, S. R. E, FISHWICK, C. W. G, STOCKLEY, P. G

“…Synthetic oligoribonucleotides have been used to probe the interaction of MS2 coat protein with the translational operator of the MS2 replicase gene. We have…”
Get full text

Preparation of Oligoribonucleotides Containing 4-Thiouridine Using Fpmp Chemistry. Photo-Crosslinking to RNA Binding Proteins Using 350 nm Irradiation by McGregor, A., Rao, M. Vaman, Duckworth, G., Stockley, P. G., Connolly, B. A.

“…The preparation of a 4-thiouridine phosphoramidite suitable for RNA synthesis and its subsequent incorporation into oligoribonucleotides is described. The…”
Get full text

Sequences required for regulation of arginine biosynthesis promoters are conserved between Bacillus subtilis and Escherichia coli by Smith, M C, Czaplewski, L, North, A K, Baumberg, S, Stockley, P G

“…The region required for regulation of a previously characterized arginine-regulatable promoter upstream from the argC gene in the argCAEBD-cpa-argF cluster of…”
Get more information

Crystal structures of a series of RNA aptamers complexed to the same protein target by Phillips, Simon E.V, Rowsell, Siân, Stonehouse, Nicola J, Convery, Máire A, Adams, Chris J, Ellington, Andrew D, Hirao, Ichiro, Peabody, David S, Stockley, Peter G

“…We have determined the crystal structures, at 2.8 A resolution, of two different RNA aptamers, each bound to MS2 coat protein. One of the aptamers contains a…”
Get full text

Biomolecular interaction analysis by Stockley, Peter G.

Get full text

Molecular mechanism of RNA-phage morphogenesis by Stockley, P G, Stonehouse, N J, Walton, C, Walters, D A, Medina, G, Macedo, J M, Hill, H R, Goodman, S T, Talbot, S J, Tewary, H K

Get more information

Filter-binding assays by Stockley, P G

Get more information