Search Results - "STO Saad"

EVALUATING THE PRO-APOPTOTIC AND ANTIOXIDANT EFFECTS OF HESPERIDIN AND HESPERETIN IN LEUKEMIA CELL LINES by IC Rocha, NG Amôr, STO Saad, MC Alvarez

“…The proliferative state of cancer cells, characterized by uncontrolled division and evasion of programmed cell death, is a hallmark of malignancy. Citrus…”
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THE MCL-1 INHIBITOR AZD5991 DISPLAYS A PROMISING TARGETED THERAPY FOR ACUTE MYELOID LEUKEMIA by MLP Bueno, STO Saad, FM Roversi

“…Aims: MCL-1 protein is an anti-apoptotic member of BCL-2 protein family. In hematological neoplasms, increased MCL-1 gene expression or protein activity is…”
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EGCG INDUCES AN INFLAMMATORY PROFILE REDUCING M2 MACROPHAGES IN A MOUSE MODEL OF MDS by FID Via, MC Alvarez, KP Ferro, I Santos, NG Amôr, STO Saad

“…Epigallocatechin-3-gallate (EGCG), a polyphenol extracted from green tea, has shown a range of beneficial effects, including the inhibition of M2 macrophage…”
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TP53 GENE EXPRESSION IS INCREASED AND CORRELATES WITH RHOC IN PATIENTS WITH ACUTE MYELOID LEUKEMIA by BA Rodrigues, SSC Sampaio, KA Lima, GRS Mendonça, STO Saad, M Lazarini

“…Background: Mutations in the tumor suppressor gene TP53 are found in approximately 10% of acute myeloid leukemia (AML) cases and are associated with a worse…”
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EXPLORING THE EFFICACY OF GALLIC ACID IN INDUCING APOPTOSIS AND MODULATING ROS IN MYELOID AND LYMPHOID LEUKEMIA CELL LINES by GV Romano, ICF Silva, I Rocha, NG Amòr, STO Saad, MC Alvarez

“…Leukemia is the fifth most prevalent cancer worldwide. Despite significant progress in treatment through new drugs, side effects remain a major challenge…”
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RHOA KNOCKDOWN AFFECTS P53 SUBCELLULAR LOCALIZATION IN LEUKEMIA CELLS IRRADIATED WITH UVC by AD Ferreira, SSC Sampaio, PSSM Ferrari, ASS Duarte, CRR Rocha, STO Saad, M Lazarini

“…Introduction and aims: Acute myeloid leukemia (AML) is a severe hematological malignancy with low rates of survival. Mutations in the tumor suppressor gene…”
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POTENTIAL EFFECTS OF CITRUS FLAVONOIDS HESPERIDIN AND ITS AGLYCONE HESPERETIN IN LEUKEMIA CELL LINE by IC Rocha, RGB Gomes, NG Amôr, STO Saad, MC Alvarez

“…Acute Myeloid Leukemia (AML) is a prevalent form of leukemia, responsible for an alarming 62% of all fatalities related to leukemia globally, and the current…”
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A NOVEL IN VITRO BONE MARROW NICHE PLATFORM FOR INVESTIGATING THERAPEUTIC STRATEGIES FOR ACUTE LEUKEMIAS by DP Echevarria, MLP Bueno, I Santos, NG Amôr, FM Roversi, AN Bruno, STO Saad

“…Aims: Acute lymphoblastic leukemia (ALL), the most prevalent childhood cancer, disrupts the hematopoietic bone marrow (BM) niche, a specialized…”
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PRIMARY EXTRANODAL LYMPHOMA EFFORT (PELÉ): COMPARISON OF PUBLIC AND PRIVATE HEALTH CARE ASSISTANCE, FROM A BRAZILIAN MULTICENTER OBSERVATIONAL STUDY by ALC Mendonça, BB Silva, G Duffles, F Galvão, E Rizzo, E Miranda, LL Perruso, RLR Baptista, STO Saad, CA Souza

“…Objective: Compare public healthcare (Pub) with private healthcare (Pri) in Brazilian patients with primary extranodal lymphoma. Methods: PELÉ is a multicenter…”
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A MULTICENTER ANALYSIS OF PRIMARY GASTRIC LYMPHOMA IN BRAZILIAN CENTERS: FIRST RESULTS OF THE PELÉ STUDY (PRIMARY EXTRANODAL LYMPHOMA EFFORT) by BB Silva, ALC Mendonça, G Duffles, F Galvão, E Rizzo, E Miranda, LL Perruso, RLR Baptista, STO Saad, CA Souza

“…Objective: Evaluate clinical and epidemiological characteristics of patients with primary gastric lymphoma (PGL) within the PELÉ study. Methods: PELÉ is a…”
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INVESTIGATING THE IMPACT OF EGCG ON INEFFECTIVE HEMATOPOIESIS IN A MDS MOUSE MODEL by FID Via, KP Ferro, GR Assis-Mendonça, P Latuf-Filho, I Santos, NG Amôr, FVP Souza, MC Alvarez, STO Saad

“…Background and aims: Green tea catechins, particularly, epigallocatechin-3-gallate (EGCG), exhibit a range of beneficial effects, like apoptosis and…”
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PIEZO1 ACTIVATION INCREASES NEUTROPHIL ADHESIVE PROPERTIES IN SICKLE CELL ANEMIA by FC Leonardo, PL Brito, S Egée, E Nader, P Connes, STO Saad, FF Costa, N Conran

“…Sickle cell anemia (SCA) is an inherited disorder caused by a mutation in the gene encoding β-globin. This mutation brings about alterations in the hemoglobin…”
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RHOC EXPRESSION CORRELATES WITH SRC AND IT IS A PROGNOSTIC FACTOR IN ACUTE MYELOID LEUKEMIA by B Contieri, LB Paiva, GB Silva, DFV Ramos, JCL Silva, JAM Neto, STO Saad, M Lazarini

“…Introduction: Acute Myeloid Leukemia (AML) is a hematologic malignancy with poor prognosis that can occur from myelodysplastic syndrome (MDS) progression. RHOC…”
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O SILENCIAMENTO DE RHOA PROVOCA ALTERAÇÕES EM LARGA ESCALA NA EXPRESSÃO GÊNICA GLOBAL DE CÉLULAS DE LEUCEMIA by MCC Ramalho, SSC Sampaio, ASS Duarte, STO Saad, M Lazarini

“…Introdução: RHOA é uma proteína Rho GTPase crucial no controle da dinâmica do citoesqueleto. Além disso, Rho GTPases também regulam a expressão gênica. A…”
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IMPACTO DO SILENCIAMENTO DAS PROTEÍNAS RHOA E RHOC NA NA AQUISIÇÃO DE DANOS AO DNA E MORTE DE CÉLULAS MIELOIDES U937 TRATADAS COM UVC by SSC Sampaio, CS Souza, BA Rodrigues, AD Ferreira, ASS Duarte, STO Saad, M Lazarini

“…Introdução: RhoA e RhoC são proteínas RHO GTPases homólogas que desempenham papéis cruciais na regulação de processos celulares, incluindo a apoptose e a…”
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O SILENCIAMENTO DA PROTEÍNA RHO GTPASE RHOA INDUZ MUDANÇAS NA EXPRESSÃO DE REGULADORES DO CICLO CELULAR E APOPTOSE EM LINHAGEM CELULAR DE LEUCEMIA MIELOIDE AGUDA by CS Souza, SSC Sampaio, MCC Ramalho, GRS Mendonça, ASS Duarte, STO Saad, CRR Rocha, M Lazarini

“…Introdução e objetivos: RHOA e RHOC são proteínas homólogas pertencentes à subfamília RHO das GTPases, desempenhando papéis centrais em processos celulares…”
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AVALIAÇÃO DA EFICÁCIA DE SUPLEMENTAÇÃO DE CONCENTRADOS DE HEMÁCIAS PARA FINS TRANSFUSIONAIS: ESTUDOS DE VIABILIDADE CELULAR E PARÂMETROS BIOQUÍMICOS by LNG Carvalho, FF Costa, MT Mesquita, STO Saad, SE Jorge, TT Jorge

“…Objetivos: investigar a qualidade dos concentrados de hemácias suplementados com 2,3-bifosfoglicerato (2,3-BPG), hexafosfato de inositol (IHP) e…”
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ESTUDO PROSPECTIVO DE COMPOSTOS PARA MELHORIA DE FUNÇÃO DA HEMOGLOBINA EM CONCENTRADO DE HEMÁCIAS by MT Mesquita, LNG Carvalho, TT Jorge, STO Saad, FF Costa, SE Jorge

“…Objetivo: Avaliar a eficácia funcional da hemoglobina (Hb) em concentrado de hemácias (CH) em bolsas de sangue suplementadas com 2,3-Bifosfoglicerato…”
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TERAPIA DE FOTOBIOMODULAÇÃO NO TRATAMENTO DE ÚLCERAS DE MEMBROS EM PACIENTES COM ANEMIA FALCIFORME: RELATO DE CASO E IMPACTO NA ANALGESIA E REGENERAÇÃO TECIDUAL by FGOM Manoel, PM Campos, SS Medina, STO Saad, BD Benites

“…Objetivos: Úlceras de membros configuram como uma das mais complexas manifestações das doenças falciformes (DF), com imenso impacto biopsicossocial: dor…”
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EXPRESSÃO DE PODOPLANINA POR CITOMETRIA DE FLUXO IDENTIFICA COM PRECISÃO PACIENTES COM LEUCEMIA PROMIELOCÍTICA AO DIAGNÓSTICO by CMA Saraiva, CRP Moraes, BKL Duarte, PM Campos, GB Oliveira, STO Saad, EV Paula

“…Introdução: Leucemia promielocítica aguda (LPA) é uma emergência que exige diagnóstico e tratamento imediatos. A suspeita se baseia na morfologia, podendo ser…”
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