Search Results - "STITZEL, Jerry A"

Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis by Bai, Xiyuan, Stitzel, Jerry A, Bai, An, Zambrano, Cristian A, Phillips, Matthew, Marrack, Philippa, Chan, Edward D

“…Pure nicotine impairs macrophage killing of Mycobacterium tuberculosis (MTB), but it is not known whether the nicotine component in cigarette smoke (CS) plays…”
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Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits by Evans, Luke M, Arehart, Christopher H, Grotzinger, Andrew D, Mize, Travis J, Brasher, Maizy S, Stitzel, Jerry A, Ehringer, Marissa A, Hoeffer, Charles A

“…It remains unknown to what extent gene-gene interactions contribute to complex traits. Here, we introduce a new approach using predicted gene expression to…”
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An innate contribution of human nicotinic receptor polymorphisms to COPD-like lesions by Routhier, Julie, Pons, Stéphanie, Freidja, Mohamed Lamine, Dalstein, Véronique, Cutrona, Jérôme, Jonquet, Antoine, Lalun, Nathalie, Mérol, Jean-Claude, Lathrop, Mark, Stitzel, Jerry A., Kervoaze, Gwenola, Pichavant, Muriel, Gosset, Philippe, Tournier, Jean-Marie, Birembaut, Philippe, Dormoy, Valérian, Maskos, Uwe

“…Chronic Obstructive Pulmonary Disease is a generally smoking-linked major cause of morbidity and mortality. Genome-wide Association Studies identified a locus…”
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Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes by Papke, Roger L, Wecker, Lynn, Stitzel, Jerry A

“…Transgenic mouse models with nicotinic acetylcholine receptor (nAChR) knockouts and knockins have provided important insights into the molecular substrates of…”
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Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice by Buck, Jordan M, O'Neill, Heidi C, Stitzel, Jerry A

“…Maternal smoking of traditional or electronic cigarettes during pregnancy, which constitutes developmental nicotine exposure (DNE), heightens the risk of…”
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Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes by Saccone, Nancy L., Saccone, Scott F., Hinrichs, Anthony L., Stitzel, Jerry A., Duan, Weimin, Pergadia, Michele L., Agrawal, Arpana, Breslau, Naomi, Grucza, Richard A., Hatsukami, Dorothy, Johnson, Eric O., Madden, Pamela A.F., Swan, Gary E., Wang, Jen C., Goate, Alison M., Rice, John P., Bierut, Laura J.

“…Tobacco smoking continues to be a leading cause of preventable death. Recent research has underscored the important role of specific cholinergic nicotinic…”
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Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice by Meyers, Erin, Werner, Zachary, Wichman, David, Mathews, Hunter L, Radcliffe, Richard A, Nadeau, Joseph H, Stitzel, Jerry A

“…The gene is strongly associated with the level of nicotine consumption in humans and manipulation of the expression or function of similarly alters nicotine…”
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RCAN1 knockout and overexpression recapitulate an ensemble of rest-activity and circadian disruptions characteristic of Down syndrome, Alzheimer's disease, and normative aging by Wong, Helen, Buck, Jordan M, Borski, Curtis, Pafford, Jessica T, Keller, Bailey N, Milstead, Ryan A, Hanson, Jessica L, Stitzel, Jerry A, Hoeffer, Charles A

“…Regulator of calcineurin 1 (RCAN1) is overexpressed in Down syndrome (DS), but RCAN1 levels are also increased in Alzheimer's disease (AD) and normal aging. AD…”
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Naturally occurring genetic variability in the nicotinic acetylcholine receptor alpha4 and alpha7 subunit genes and phenotypic diversity in humans and mice by Stitzel, Jerry A

“…Through the use of pharmacological and molecular strategies, the identities of the nicotinic acetylcholine receptor (nAChR) subtypes that modulate different…”
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Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expression by Gallego, Xavier, Cox, Ryan J, Laughlin, James R, Stitzel, Jerry A, Ehringer, Marissa A

“…Common genetic factors strongly contribute to both nicotine, the main addictive component of tobacco, and alcohol use. Several lines of evidence suggest…”
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The effects of oral nicotine administration and abstinence on sleep in male C57BL/6J mice by Mathews, Hunter L., Stitzel, Jerry A.

“…Background Sleep disturbances are common in smoking cessation attempts and are predictive of relapse. Despite this knowledge, there is no established animal…”
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Chrna4 A529 knock-in mice exhibit altered nicotine sensitivity by Wilking, Jennifer A, Hesterberg, Kirstin G, Crouch, Eric L, Homanics, Gregg E, Stitzel, Jerry A

“…The reasons why people smoke are varied, but research has shown that genetic influences on various aspects of nicotine addiction are a major factor. There also…”
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Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice by Buck, Jordan M., Sanders, Kelsey N., Wageman, Charles R., Knopik, Valerie S., Stitzel, Jerry A., O'Neill, Heidi C.

“…Maternal smoking during pregnancy, a form of developmental nicotine exposure (DNE), is associated with increased nicotine use and neurodevelopmental disorders…”
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Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice by Buck, Jordan M., O'Neill, Heidi C., Stitzel, Jerry A.

“…[Display omitted] Maternal smoking of conventional or vapor cigarettes during pregnancy, a form of developmental nicotine exposure (DNE), enhances the risk of…”
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Crucial role of nicotinic alpha 5 subunit variants for Ca2+ fluxes in ventral midbrain neurons by Sciaccaluga, Miriam, Moriconi, Claudia, Martinello, Katiuscia, Catalano, Myriam, Bermudez, Isabel, Stitzel, Jerry A, Maskos, Uwe, Fucile, Sergio

“…Neuronal nicotinic acetylcholine receptors (nAChRs) containing the alpha 5 subunit modulate nicotine consumption, and the human CHRNA5 rs16969968 polymorphism,…”
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DNA methylome perturbations: an epigenetic basis for the emergingly heritable neurodevelopmental abnormalities associated with maternal smoking and maternal nicotine exposure by Buck, Jordan M., Yu, Li, Knopik, Valerie S., Stitzel, Jerry A.

“…Maternal smoking during pregnancy is associated with an ensemble of neurodevelopmental consequences in children and therefore constitutes a pressing public…”
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Investigating the role of nicotinic acetylcholine receptors in menthol's effects in mice by Akinola, Lois S., Gonzales, Jada, Buzzi, Belle, Mathews, Hunter L., Papke, Roger L., Stitzel, Jerry A., Damaj, M. Imad

“…The use of menthol in tobacco products has been linked to an increased likelihood of developing nicotine dependence. The widespread use of menthol can be…”
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Mutation of the α5 nicotinic acetylcholine receptor subunit increases ethanol and nicotine consumption in adolescence and impacts adult drug consumption by Quijano Cardé, Natalia A., Shaw, Jessica, Carter, Christina, Kim, Seung, Stitzel, Jerry A., Venkatesh, Shyamala K., Ramchandani, Vijay A., De Biasi, Mariella

“…Alcohol and nicotine are commonly used during adolescence, establishing long-lasting neuroplastic alterations that influence subsequent drug use and abuse…”
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The Intergenerational Transmission of Developmental Nicotine Exposure-Induced Neurodevelopmental Disorder-Like Phenotypes is Modulated by the Chrna5 D397N Polymorphism in Adolescent Mice by Buck, Jordan M., O’Neill, Heidi C., Stitzel, Jerry A.

“…Maternal tobacco smoking during pregnancy constitutes developmental nicotine exposure (DNE) and is associated with nicotine dependence and neurodevelopmental…”
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Testing Association of Previously Implicated Gene Sets and Gene-Networks in Nicotine Exposed Mouse Models with Human Smoking Phenotypes by Mize, Travis J, Funkhouser, Scott A, Buck, Jordan M, Stitzel, Jerry A, Ehringer, Marissa A, Evans, Luke M

“…Abstract Introduction Smoking behaviors are partly heritable, yet the genetic and environmental mechanisms underlying smoking phenotypes are not fully…”
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