Search Results - "STILES, Linsey"

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes by Li, Jiwen, Pan, Lin, Pembroke, William G., Rexach, Jessica E., Godoy, Marlesa I., Condro, Michael C., Alvarado, Alvaro G., Harteni, Mineli, Chen, Yen-Wei, Stiles, Linsey, Chen, Angela Y., Wanner, Ina B., Yang, Xia, Goldman, Steven A., Geschwind, Daniel H., Kornblum, Harley I., Zhang, Ye

“…Astrocytes play important roles in neurological disorders such as stroke, injury, and neurodegeneration. Most knowledge on astrocyte biology is based on…”
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In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer by Momcilovic, Milica, Jones, Anthony, Bailey, Sean T., Waldmann, Christopher M., Li, Rui, Lee, Jason T., Abdelhady, Gihad, Gomez, Adrian, Holloway, Travis, Schmid, Ernst, Stout, David, Fishbein, Michael C., Stiles, Linsey, Dabir, Deepa V., Dubinett, Steven M., Christofk, Heather, Shirihai, Orian, Koehler, Carla M., Sadeghi, Saman, Shackelford, David B.

“…Mitochondria are essential regulators of cellular energy and metabolism, and have a crucial role in sustaining the growth and survival of cancer cells. A…”
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Mitochondrial dynamics and morphology in beta-cells by Stiles, Linsey, Ph.D, Shirihai, Orian S., M.D., Ph.D

“…Mitochondrial dynamics contribute to the regulation of mitochondrial shape as well as various mitochondrial functions and quality control. This is of…”
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Sex differences in the neuronal transcriptome and synaptic mitochondrial function in the cerebral cortex of a multiple sclerosis model by Itoh, Noriko, Itoh, Yuichiro, Stiles, Linsey, Voskuhl, Rhonda

“…Multiple sclerosis (MS) affects the cerebral cortex, inducing cortical atrophy and neuronal and synaptic pathology. Despite the fact that women are more…”
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Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis by Mahdaviani, Kiana, Benador, Ilan Y, Su, Shi, Gharakhanian, Raffi A, Stiles, Linsey, Trudeau, Kyle M, Cardamone, Maria, Enríquez‐Zarralanga, Violeta, Ritou, Eleni, Aprahamian, Tamar, Oliveira, Marcus F, Corkey, Barbara E, Perissi, Valentina, Liesa, Marc, Shirihai, Orian S

“…BAT‐controlled thermogenic activity is thought to be required for its capacity to prevent the development of insulin resistance. This hypothesis predicts that…”
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Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies by Acin‐Perez, Rebeca, Benincá, Cristiane, Fernandez del Rio, Lucia, Shu, Cynthia, Baghdasarian, Siyouneh, Zanette, Vanessa, Gerle, Christoph, Jiko, Chimari, Khairallah, Ramzi, Khan, Shaharyar, Rincon Fernandez Pacheco, David, Shabane, Byourak, Erion, Karel, Masand, Ruchi, Dugar, Sundeep, Ghenoiu, Cristina, Schreiner, George, Stiles, Linsey, Liesa, Marc, Shirihai, Orian S

“…The maintenance of cellular function relies on the close regulation of adenosine triphosphate (ATP) synthesis and hydrolysis. ATP hydrolysis by mitochondrial…”
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Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas by Do Rhee, Kun, Wang, Yanjie, ten Hoeve, Johanna, Stiles, Linsey, Nguyen, Thao Thi Thu, Zhang, Xiangmei, Vergnes, Laurent, Reue, Karen, Shirihai, Orian, Bok, Dean, Yang, Xian-Jie

“…Ciliary neurotrophic factor (CNTF) acts as a potent neuroprotective cytokine in multiple models of retinal degeneration. To understand mechanisms underlying…”
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Leptin Regulation of the Mesoaccumbens Dopamine Pathway by Fulton, Stephanie, Pissios, Pavlos, Manchon, Ramon Pinol, Stiles, Linsey, Frank, Lauren, Pothos, Emmanuel N., Maratos-Flier, Eleftheria, Flier, Jeffrey S.

“…Leptin is an adipose-derived hormone that acts on hypothalamic leptin receptors to regulate energy balance. Leptin receptors are also expressed in…”
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Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice by Moore, Timothy M, Lin, Amanda J, Strumwasser, Alexander R, Cory, Kevin, Whitney, Kate, Ho, Theodore, Ho, Timothy, Lee, Joseph L, Rucker, Daniel H, Nguyen, Christina Q, Yackly, Aidan, Mahata, Sushil K, Wanagat, Jonathan, Stiles, Linsey, Turcotte, Lorraine P, Crosbie, Rachelle H, Zhou, Zhenqi

“…Duchenne muscular dystrophy (DMD) is characterized by rapid wasting of skeletal muscle. Mitochondrial dysfunction is a well-known pathological feature of DMD…”
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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy by Twig, Gilad, Elorza, Alvaro, Molina, Anthony J A, Mohamed, Hibo, Wikstrom, Jakob D, Walzer, Gil, Stiles, Linsey, Haigh, Sarah E, Katz, Steve, Las, Guy, Alroy, Joseph, Wu, Min, Py, Bénédicte F, Yuan, Junying, Deeney, Jude T, Corkey, Barbara E, Shirihai, Orian S

“…Accumulation of depolarized mitochondria within β‐cells has been associated with oxidative damage and development of diabetes. To determine the source and fate…”
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Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis by MOLINA, Anthony J. A, WIKSTROM, Jakob D, SHIRIHAI, Orian S, STILES, Linsey, LAS, Guy, MOHAMED, Hibo, ELORZA, Alvaro, WALZER, Gil, TWIG, Gilad, KATZ, Steve, CORKEY, Barbara E

“…Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis Anthony J.A. Molina 1 , Jakob D. Wikstrom 1 , 2 , Linsey Stiles 1 , 3 , Guy Las 1 ,…”
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Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors by Woodhead, Jeffrey L, Brock, William J, Roth, Sharin E, Shoaf, Susan E, Brouwer, Kim L R, Church, Rachel, Grammatopoulos, Tom N, Stiles, Linsey, Siler, Scott Q, Howell, Brett A, Mosedale, Merrie, Watkins, Paul B, Shoda, Lisl K M

“…Tolvaptan is a selective vasopressin V2 receptor antagonist, approved in several countries for the treatment of hyponatremia and autosomal dominant polycystic…”
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Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels by Taddeo, Evan P, Alsabeeh, Nour, Baghdasarian, Siyouneh, Wikstrom, Jakob D, Ritou, Eleni, Sereda, Samuel, Erion, Karel, Li, Jin, Stiles, Linsey, Abdulla, Muhamad, Swanson, Zachary, Wilhelm, Joshua J, Bellin, Melena D, Kibbey, Richard G, Liesa, Marc, Shirihai, Orian S

“…Fasting hyperinsulinemia precedes the development of type 2 diabetes. However, it is unclear whether fasting insulin hypersecretion is a primary driver of…”
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Utilization of Human Samples for Assessment of Mitochondrial Bioenergetics: Gold Standards, Limitations, and Future Perspectives by Acin-Perez, Rebeca, Benincá, Cristiane, Shabane, Byourak, Shirihai, Orian S, Stiles, Linsey

“…Mitochondrial bioenergetic function is a central component of cellular metabolism in health and disease. Mitochondrial oxidative phosphorylation is critical…”
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Measuring Mitochondrial Respiration in Previously Frozen Biological Samples by Osto, Corey, Benador, Ilan Y, Ngo, Jennifer, Liesa, Marc, Stiles, Linsey, Acin-Perez, Rebeca, Shirihai, Orian S

“…Measuring oxygen consumption allows for the role of mitochondrial function in biological phenomena and mitochondrial diseases to be determined. Although…”
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A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets by Wikstrom, Jakob D, Sereda, Samuel B, Stiles, Linsey, Elorza, Alvaro, Allister, Emma M, Neilson, Andy, Ferrick, David A, Wheeler, Michael B, Shirihai, Orian S

“…The pancreatic beta cell is unique in its response to nutrient by increased fuel oxidation. Recent studies have demonstrated that oxygen consumption rate (OCR)…”
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Measuring CPT-1-mediated respiration in permeabilized cells and isolated mitochondria by Yang, Krista, Doan, Mary T., Stiles, Linsey, Divakaruni, Ajit S.

“…Carnitine palmitoyltransferase-1 (CPT-1) is a rate-controlling enzyme for long-chain fatty acid oxidation. This manuscript provides protocols for measuring…”
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Sex-specific metabolic functions of adipose Lipocalin-2 by Chella Krishnan, Karthickeyan, Sabir, Simon, Shum, Michaël, Meng, Yonghong, Acín-Pérez, Rebeca, Lang, Jennifer M., Floyd, Raquel R., Vergnes, Laurent, Seldin, Marcus M., Fuqua, Brie K., Jayasekera, Dulshan W., Nand, Sereena K., Anum, Diana C., Pan, Calvin, Stiles, Linsey, Péterfy, Miklós, Reue, Karen, Liesa, Marc, Lusis, Aldons J.

“…Lipocalin-2 (LCN2) is a secreted protein involved in innate immunity and has also been associated with several cardiometabolic traits in both mouse and human…”
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Sex-specific genetic regulation of adipose mitochondria and metabolic syndrome by Ndufv2 by Chella Krishnan, Karthickeyan, Vergnes, Laurent, Acín-Pérez, Rebeca, Stiles, Linsey, Shum, Michael, Ma, Lijiang, Mouisel, Etienne, Pan, Calvin, Moore, Timothy M., Péterfy, Miklós, Romanoski, Casey E., Reue, Karen, Björkegren, Johan L. M., Laakso, Markku, Liesa, Marc, Lusis, Aldons J.

“…We have previously suggested a central role for mitochondria in the observed sex differences in metabolic traits. However, the mechanisms by which sex…”
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Individual islet respirometry reveals functional diversity within the islet population of mice and human donors by Taddeo, Evan P., Stiles, Linsey, Sereda, Samuel, Ritou, Eleni, Wolf, Dane M., Abdullah, Muhamad, Swanson, Zachary, Wilhelm, Josh, Bellin, Melena, McDonald, Patrick, Caradonna, Kacey, Neilson, Andrew, Liesa, Marc, Shirihai, Orian S.

“…Islets from the same pancreas show remarkable variability in glucose sensitivity. While mitochondrial respiration is essential for glucose-stimulated insulin…”
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