Search Results - "STEWART, Trina"

Improving cancer immunotherapy by targeting tumor-induced immune suppression by Stewart, Trina J., Smyth, Mark J.

“…The status of a host’s immune response influences both the development and progression of a malignancy such that immune responses can have both pro- and…”
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Tissues in Different Anatomical Sites Can Sculpt and Vary the Tumor Microenvironment to Affect Responses to Therapy by Devaud, Christel, Westwood, Jennifer A, John, Liza B, Flynn, Jacqueline K, Paquet-Fifield, Sophie, Duong, Connie PM, Yong, Carmen SM, Pegram, Hollie J, Stacker, Steven A, Achen, Marc G, Stewart, Trina J, Snyder, Linda A, Teng, Michele WL, Smyth, Mark J, Darcy, Phillip K, Kershaw, Michael H

“…The tumor microenvironment can promote tumor growth and reduce treatment efficacy. Tumors can occur in many sites in the body, but how surrounding normal…”
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A role for CCL2 in both tumor progression and immunosurveillance by Li, Ming, Knight, Deborah A, Snyder, Linda A, Smyth, Mark J, Stewart, Trina J

“…The chemokine CCL2, which is best known for its chemotactic functions, is expressed not only by immune cells, but also by several types of malignant and…”
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Oncolytic Virus and Anti―4-1BB Combination Therapy Elicits Strong Antitumor Immunity against Established Cancer by JOHN, Liza B, HOWLAND, Linda J, SMYTH, Mark J, KERSHAW, Michael H, DARCY, Phillip K, FLYNN, Jacqueline K, WEST, Alison C, DEVAUD, Christel, DUONG, Connie P, STEWART, Trina J, WESTWOOD, Jenny A, SHENG GUO, Z, BARTLETT, David L

“…Oncolytic virotherapy using vaccinia virus (Vv) has shown some encouraging antitumor responses in mouse models and patients, but the breadth of efficacy in…”
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Altered Immune Function during Long-Term Host-Tumor Interactions Can Be Modulated to Retard Autochthonous Neoplastic Growth by Stewart, Trina J, Abrams, Scott I

“…Ag-specific and generalized forms of immunosuppression have been documented in animal tumor models. However, much of our knowledge on tumor-induced…”
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The Curative Outcome of Radioimmunotherapy in a Mouse Breast Cancer Model Relies on mTOR Signaling by Verbrugge, Inge, Gasparini, Alessia, Haynes, Nicole M., Hagekyriakou, Jim, Galli, Mara, Stewart, Trina J., Abrams, Scott I., Yagita, Hideo, Verheij, Marcel, Johnstone, Ricky W., Borst, Jannie, Neefjes, Jacques

“…Radiotherapy is a successful treatment modality for localized cancer. Our group has been exploring radiotherapy in combination with immunotherapy…”
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Sensitivity of a novel model of mammary cancer stem cell-like cells to TNF-related death pathways by Li, Ming, Knight, Deborah A., Smyth, Mark J., Stewart, Trina J.

“…Cancer stem cells (CSC) are resistant to radiation and chemotherapy and play a significant role in cancer recurrence and metastatic disease. It is therefore…”
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Modulating the Expression of IFN Regulatory Factor 8 Alters the Protumorigenic Behavior of CD11b+Gr-1+ Myeloid Cells by Stewart, Trina J, Liewehr, David J, Steinberg, Seth M, Greeneltch, Kristy M, Abrams, Scott I

“…CD11b(+)Gr-1(+)-expressing cells, termed myeloid-derived suppressor cells, can mediate immunosuppression and tumor progression. However, the intrinsic…”
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Interferon regulatory factor‐8 modulates the development of tumour‐induced CD11b+Gr‐1+ myeloid cells by Stewart, Trina J., Greeneltch, Kristy M., Reid, Julia E., Liewehr, David J., Steinberg, Seth M., Liu, Kebin, Abrams, Scott I.

“…Tumour‐induced myeloid‐derived suppressor cells (MDSC) promote immune suppression and mediate tumour progression. However, the molecular basis for the…”
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Downregulation of IFN‐γR in association with loss of Fas function is linked to tumor progression by Yang, Dafeng, Stewart, Trina J., Smith, Kimberly K., Georgi, David, Abrams, Scott I., Liu, Kebin

“…The host immune system functions as an intrinsic surveillance network in the recognition and destruction of tumor cells, and it has been demonstrated that…”
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Host Immunosurveillance Controls Tumor Growth via IFN Regulatory Factor-8-Dependent Mechanisms by GREENELTCH, Kristy M, SCHNEIDER, Monika, STEINBERG, Seth M, LIEWEHR, David J, STEWART, Trina J, KEBIN LIU, ABRAMS, Scott I

“…IFN regulatory factor (IRF)-8 plays an important role in normal myelopoiesis. The loss of IRF-8 in myeloid cells results in a chronic myelogenous leukemia-like…”
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Inhibition of early tumor growth requires Jα18-positive (natural killer T) cells by STEWART, Trina J, SMYTH, Mark J, FERNANDO, Germain J. P, FRAZER, Ian H, LEGGATT, Graham R

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Immune Consequences of Protracted Host-Tumor Interactions in a Transgenic Mouse Model of Mammary Carcinoma by Stewart, Trina J., Christine Lutsiak, M. E., Abrams, Scott I.

“…A transgenic mouse model of autochthonous mammary carcinoma was chosen to study the impact of tumor progression on the immune system over an extended period…”
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ISCOMATRIX™ adjuvant: an adjuvant suitable for use in anticancer vaccines by Stewart, Trina J, Drane, Debbie, Malliaros, Jim, Elmer, Heidi, Malcolm, Karen M, Cox, John C, Edwards, Stirling J, Frazer, Ian H, Fernando, Germain J.P

“…Human Papillomavirus type 16 (HPV16) E6 and E7 oncoproteins are associated with cervical cancer development and progression and can therefore be used as target…”
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Immunological responses can have both pro- and antitumour effects: implications for immunotherapy by Stewart, Trina J, Greeneltch, Kristy M, Lutsiak, M E Christine, Abrams, Scott I

“…Immune responses influence the development and progression of a malignancy. The tumour can also manipulate the immune system to its own ends, often resulting…”
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Association of antigens to ISCOMATRIX™ adjuvant using metal chelation leads to improved CTL responses by Malliaros, Jim, Quinn, Charles, Arnold, Frances H., Pearse, Martin J., Drane, Debbie P., Stewart, Trina J., Macfarlan, Roderick I.

“…The association of antigen with ISCOMATRIX™ adjuvant has been shown to be important for the optimal induction of cytotoxic T lymphocyte (CTL) responses. Here,…”
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Chemokine-chemokine receptors in cancer immunotherapy by Stewart, Trina J, Smyth, Mark J

“…A surge in interest in the chemokine-chemokine receptor network is probably related to the expanding roles that chemokines have now been identified to play in…”
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CpG Immunomer DNA Enhances Antisense Protein Kinase A RIα Inhibition of Multidrug-Resistant Colon Carcinoma Growth in Nude Mice: Molecular Basis for Combinatorial Therapy by NESTEROVA, Maria V, JOHNSON, Natalie R, STEWART, Trina, ABRAMS, Scott, CHO-CHUNG, Yoon S

“…Purpose: CpG DNAs induce cytokines, activate natural killer cells, and elicit vigorous T-cell response leading to antitumor effects. Antisense…”
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Th2-Type CD4+ Cells Neither Enhance nor Suppress Antitumor CTL Activity in a Mouse Tumor Model by Fernando, Germain J. P, Stewart, Trina J, Tindle, Robert W, Frazer, Ian H

“…Many cervical cancers express the E7 protein of human papillomavirus 16 as a tumor-specific Ag (TSA). To establish the role of E7-specific T cell help in CD8+…”
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Tumour susceptibility to innate and adaptive immunotherapy changes during tumour maturation by Stewart, Trina J, Fernando, Germain JP, Frazer, Ian H, Leggatt, Graham R

“…Immunotherapy of tumours using T cells expanded in vitro has met with mixed clinical success suggesting that a greater understanding of tumour/T‐cell…”
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