Search Results - "STEWART, David B"

Advances in therapeutic bacterial antisense biotechnology by Hegarty, John P., Stewart, David B.

“…Antisense therapeutics are a biotechnological form of antibiotic therapy using chemical analogues of short single-stranded nucleic acid sequences modified to…”
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ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections by Kelly, Colleen R., Fischer, Monika, Allegretti, Jessica R., LaPlante, Kerry, Stewart, David B., Limketkai, Berkeley N., Stollman, Neil H.

“…Clostridioides difficile infection occurs when the bacterium produces toxin that causes diarrhea and inflammation of the colon. These guidelines indicate the…”
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Induction short-course radiotherapy with consolidation chemotherapy for locally-advanced rectal cancer: Is a long run and short slide preferred? by Stewart, David B.

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Clinical Practice Guideline for the Management of Anal Fissures by Stewart, David B, Gaertner, Wolfgang, Glasgow, Sean, Migaly, John, Feingold, Daniel, Steele, Scott R

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Individualized care or ad hoc care: Is evidence based, personalized care for diverticulitis currently possible? by Stewart, David B.

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The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients by Schieffer, Kathleen M., Sabey, Kate, Wright, Justin R., Toole, David R., Drucker, Rebecca, Tokarev, Vasily, Harris, Leonard R., Deiling, Sue, Eshelman, Melanie A., Hegarty, John P., Yochum, Gregory S., Koltun, Walter A., Lamendella, Regina, Stewart, David B.

“…Diverticular disease is commonly associated with the older population in the United States. As individual’s age, diverticulae, or herniation of the mucosa…”
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Clinical Practice Guideline for the Surgical Management of Crohn’s Disease by Strong, Scott, Steele, Scott R, Boutrous, Marylise, Bordineau, Liliana, Chun, Jonathan, Stewart, David B, Vogel, Jon, Rafferty, Janice F

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Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile by Hegarty, John P, Krzeminski, Jacek, Sharma, Arun K, Guzman-Villanueva, Diana, Weissig, Volkmar, Stewart, Sr, David B

“…Despite being a conceptually appealing alternative to conventional antibiotics, a major challenge toward the successful implementation of antisense treatments…”
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Bacterial and Fungal Microbiota Changes Distinguish C. difficile Infection from Other Forms of Diarrhea: Results of a Prospective Inpatient Study by Sangster, William, Hegarty, John P, Schieffer, Kathleen M, Wright, Justin R, Hackman, Jada, Toole, David R, Lamendella, Regina, Stewart, Sr, David B

“…This study sought to characterize the bacterial and fungal microbiota changes associated with Clostridium difficile infection (CDI) among inpatients with…”
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Development and Validation of a Prediction Model for Mortality and Adverse Outcomes Among Patients With Peripheral Eosinopenia on Admission for Clostridium difficile Infection by Kulaylat, Audrey S, Buonomo, Erica L, Scully, Kenneth W, Hollenbeak, Christopher S, Cook, Heather, Petri, Jr, William A, Stewart, Sr, David B

“…Recent evidence from an animal model suggests that peripheral loss of eosinophils in Clostridium difficile infection (CDI) is associated with severe disease…”
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Phage tail-like particles kill Clostridium difficile and represent an alternative to conventional antibiotics by Sangster, William, MD, Hegarty, John P., PhD, Stewart, David B., MD, FACS, FASCRS

“…Background Current Clostridium difficile infection (CDI) antibiotic regimens have become increasingly ineffective at achieving cure and preventing recurrence…”
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Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile by Sharma, Arun K., Krzeminski, Jacek, Weissig, Volkmar, Hegarty, John P., Stewart, David B.

“…Conventional antibiotics for C. difficile infection (CDI) have mechanisms of action without organismal specificity, potentially perpetuating the dysbiosis…”
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Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities by Chen See, Jeremy R, Leister, Jillian, Wright, Justin R, Kruse, Peter I, Khedekar, Mohini V, Besch, Catharine E, Kumamoto, Carol A, Madden, Gregory R, Stewart, David B, Lamendella, Regina

“…infection (CDI) is responsible for around 300,000 hospitalizations yearly in the United States, with the associated monetary cost being billions of dollars…”
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A Nightlight for Adults? A Commentary on “Identifying Ureters In Situ Under Fluorescence During Laparoscopic and Open Colorectal Surgery” by Stewart, David B

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Determinants of 30-d readmission after colectomy by Kulaylat, Afif N., MD, Dillon, Peter W., MD, MSc, Hollenbeak, Christopher S., PhD, Stewart, David B., MD

“…Abstract Background Readmission after colectomy has become an important metric for measuring quality of care. Our aim was to investigate the impact of patient…”
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Correlation between virulence gene expression and proton pump inhibitors and ambient pH in Clostridium difficile: results of an in vitro study by STEWART, David B, HEGARTY, John P

“…Proton pump inhibitors (PPIs) are associated with the development of Clostridium difficile infection in humans. Though it is assumed that PPIs mediate this…”
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Squamous Cancers of the Rectum Demonstrate Poorer Survival and Increased Need for Salvage Surgery Compared With Squamous Cancers of the Anus by Kulaylat, Audrey S, Hollenbeak, Christopher S, Stewart, David B

“…BACKGROUND:Squamous cell cancers of the anus are rare GI malignancies for which neoadjuvant chemoradiation is the first-line treatment for nonmetastatic…”
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Fecal Incontinence Among Patients With Crohn’s Disease: Does Awareness Change Anything? by Stewart, David B

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Updated USPSTF Guidelines for Colorectal Cancer Screening: The Earlier the Better by Stewart, David B

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Integrated Meta-omics Reveals a Fungus-Associated Bacteriome and Distinct Functional Pathways in Clostridioides difficile Infection by Stewart, Sr, David B, Wright, Justin R, Fowler, Maria, McLimans, Christopher J, Tokarev, Vasily, Amaniera, Isabella, Baker, Owen, Wong, Hoi-Tong, Brabec, Jeff, Drucker, Rebecca, Lamendella, Regina

“…There has been no prior application of matched metagenomics and metatranscriptomics in infection (CDI) evaluating the role of fungi in CDI or identifying…”
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