Search Results - "STEVEN, ALASDAIR C."

At Low pH, Influenza Virus Matrix Protein M1 Undergoes a Conformational Change Prior to Dissociating from the Membrane by Fontana, Juan, Steven, Alasdair C

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Distribution and Redistribution of HIV-1 Nucleocapsid Protein in Immature, Mature, and Integrase-Inhibited Virions: a Role for Integrase in Maturation by Fontana, Juan, Jurado, Kellie A, Cheng, Naiqian, Ly, Ngoc L, Fuchs, James R, Gorelick, Robert J, Engelman, Alan N, Steven, Alasdair C

“…During virion maturation, HIV-1 capsid protein assembles into a conical core containing the viral ribonucleoprotein (vRNP) complex, thought to be composed…”
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Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins by Varkey, Jobin, Isas, Jose Mario, Mizuno, Naoko, Jensen, Martin Borch, Bhatia, Vikram Kjøller, Jao, Christine C., Petrlova, Jitka, Voss, John C., Stamou, Dimitrios G., Steven, Alasdair C., Langen, Ralf

“…Synucleins and apolipoproteins have been implicated in a number of membrane and lipid trafficking events. Lipid interaction for both types of proteins is…”
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Structural engineering of a phage lysin that targets Gram-negative pathogens by Lukacik, Petra, Barnard, Travis J, Keller, Paul W, Chaturvedi, Kaveri S, Seddiki, Nadir, Fairman, James W, Noinaj, Nicholas, Kirby, Tara L, Henderson, Jeffrey P, Steven, Alasdair C, Hinnebusch, B. Joseph, Buchanan, Susan K

“…Bacterial pathogens are becoming increasingly resistant to antibiotics. As an alternative therapeutic strategy, phage therapy reagents containing purified…”
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Structural Changes in Influenza Virus at Low pH Characterized by Cryo-Electron Tomography by FONTANA, Juan, CARDONE, Giovanni, HEYMANN, J. Bernard, WINKLER, Dennis C, STEVEN, Alasdair C

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Cryo-EM structure in situ reveals a molecular switch that safeguards virus against genome loss by Bayfield, Oliver W, Steven, Alasdair C, Antson, Alfred A

“…The portal protein is a key component of many double-stranded DNA viruses, governing capsid assembly and genome packaging. Twelve subunits of the portal…”
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Structure and assembly of a paramyxovirus matrix protein by Battisti, Anthony J, Meng, Geng, Winkler, Dennis C, McGinnes, Lori W, Plevka, Pavel, Steven, Alasdair C, Morrison, Trudy G, Rossmann, Michael G

“…Many pleomorphic, lipid-enveloped viruses encode matrix proteins that direct their assembly and budding, but the mechanism of this process is unclear. We have…”
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Structural basis for iron piracy by pathogenic Neisseria by Noinaj, Nicholas, Easley, Nicole C., Oke, Muse, Mizuno, Naoko, Gumbart, James, Boura, Evzen, Steere, Ashley N., Zak, Olga, Aisen, Philip, Tajkhorshid, Emad, Evans, Robert W., Gorringe, Andrew R., Mason, Anne B., Steven, Alasdair C., Buchanan, Susan K.

“…Neisseria are obligate human pathogens causing bacterial meningitis, septicaemia and gonorrhoea. Neisseria require iron for survival and can extract it…”
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Structural dependence of HET-s amyloid fibril infectivity assessed by cryoelectron microscopy by Mizuno, Naoko, Baxa, Ulrich, Steven, Alasdair C

“…HET-s is a prion protein of the fungus Podospora anserina which, in the prion state, is active in a self/nonself recognition process called heterokaryon…”
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Influenza Virus Pleiomorphy Characterized by Cryoelectron Tomography by Harris, Audray, Cardone, Giovanni, Winkler, Dennis C., Bernard Heymann, J., Brecher, Matthew, Whitet, Judith M., Steven, Alasdair C.

“…Influenza virus remains a global health threat, with millions of infections annually and the impending threat that a strain of avian influenza may develop into…”
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Arrangement of L2 within the Papillomavirus Capsid by BUCK, Christopher B, NAIQIAN CHENG, THOMPSON, Cynthia D, LOWY, Douglas R, STEVEN, Alasdair C, SCHILLER, John T, TRUS, Benes L

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Functional architecture of the retromer cargo-recognition complex by Murthy, Namita, Hierro, Aitor, Hurley, James H, Effantin, Grégory, Steven, Alasdair C, Bonifacino, Juan S, Rojas, Raul, Kajava, Andrey V, Rojas, Adriana L

“…The retromer complex is required for the sorting of acid hydrolases to lysosomes, transcytosis of the polymeric immunoglobulin receptor, Wnt gradient…”
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Subunit Folds and Maturation Pathway of a dsRNA Virus Capsid by Nemecek, Daniel, Boura, Evzen, Wu, Weimin, Cheng, Naiqian, Plevka, Pavel, Qiao, Jian, Mindich, Leonard, Heymann, J. Bernard, Hurley, James H., Steven, Alasdair C.

“…The cystovirus ϕ6 shares several distinct features with other double-stranded RNA (dsRNA) viruses, including the human pathogen, rotavirus: segmented genomes,…”
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Expression of quasi-equivalence and capsid dimorphism in the Hepadnaviridae by Wu, Weimin, Watts, Norman R, Cheng, Naiqian, Huang, Rick, Steven, Alasdair C, Wingfield, Paul T

“…Hepatitis B virus (HBV) is a leading cause of liver disease. The capsid is an essential component of the virion and it is therefore of interest how it…”
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Structural Basis of hAT Transposon End Recognition by Hermes, an Octameric DNA Transposase from Musca domestica by Hickman, Alison B., Ewis, Hosam E., Li, Xianghong, Knapp, Joshua A., Laver, Thomas, Doss, Anna-Louise, Tolun, Gökhan, Steven, Alasdair C., Grishaev, Alexander, Bax, Ad, Atkinson, Peter W., Craig, Nancy L., Dyda, Fred

“…Hermes is a member of the hAT transposon superfamily that has active representatives, including McClintock’s archetypal Ac mobile genetic element, in many…”
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The RNA-Binding Protein of a Double-Stranded RNA Virus Acts like a Scaffold Protein by Mata, Carlos P, Mertens, Johann, Fontana, Juan, Luque, Daniel, Allende-Ballestero, Carolina, Reguera, David, Trus, Benes L, Steven, Alasdair C, Carrascosa, José L, Castón, José R

“…Infectious bursal disease virus (IBDV), a nonenveloped, double-stranded RNA (dsRNA) virus with a T=13 icosahedral capsid, has a virion assembly strategy that…”
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HIV-1 Maturation Inhibitor Bevirimat Stabilizes the Immature Gag Lattice by KELLER, Paul W, ADAMSON, Catherine S, BERNARD HEYMANN, J, FREED, Eric O, STEVEN, Alasdair C

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Antigenic Switching of Hepatitis B Virus by Alternative Dimerization of the Capsid Protein by DiMattia, Michael A., Watts, Norman R., Stahl, Stephen J., Grimes, Jonathan M., Steven, Alasdair C., Stuart, David I., Wingfield, Paul T.

“…Chronic hepatitis B virus (HBV) infection afflicts millions worldwide with cirrhosis and liver cancer. HBV e-antigen (HBeAg), a clinical marker for disease…”
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A Two-Pronged Structural Analysis of Retroviral Maturation Indicates that Core Formation Proceeds by a Disassembly-Reassembly Pathway Rather than a Displacive Transition by Keller, Paul W, Huang, Rick K, England, Matthew R, Waki, Kayoko, Cheng, Naiqian, Heymann, J Bernard, Craven, Rebecca C, Freed, Eric O, Steven, Alasdair C

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INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication by Dixit, Updesh, Bhutoria, Savita, Wu, Xuhong, Qiu, Liming, Spira, Menachem, Mathew, Sheeba, Harris, Richard, Adams, Lucas J., Cahill, Sean, Pathak, Rajiv, Rajesh Kumar, P., Nguyen, Minh, Acharya, Seetharama A., Brenowitz, Michael, Almo, Steven C., Zou, Xiaoqin, Steven, Alasdair C., Cowburn, David, Girvin, Mark, Kalpana, Ganjam V.

“…INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits multifaceted role in HIV-1 replication. Determining the NMR structure of…”
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