Search Results - "STETINA, Rudolf"

The comet assay: topical issues by Collins, Andrew R., Oscoz, Amaia Azqueta, Brunborg, Gunnar, Gaivão, Isabel, Giovannelli, Lisa, Kruszewski, Marcin, Smith, Catherine C., Štětina, Rudolf

“…The comet assay is a versatile and sensitive method for measuring single- and double-strand breaks in DNA. The mechanism of formation of comets (under neutral…”
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Oxidative Damage in Sporadic Colorectal Cancer: Molecular Mapping of Base Excision Repair Glycosylases in Colorectal Cancer Patients by Vodicka, Pavel, Urbanova, Marketa, Makovicky, Pavol, Tomasova, Kristyna, Kroupa, Michal, Stetina, Rudolf, Opattova, Alena, Kostovcikova, Klara, Siskova, Anna, Schneiderova, Michaela, Vymetalkova, Veronika, Vodickova, Ludmila

“…Oxidative stress with subsequent premutagenic oxidative DNA damage has been implicated in colorectal carcinogenesis. The repair of oxidative DNA damage is…”
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Sulfur mustard induced oxidative stress and its alteration by epigallocatechin gallate by Pohanka, Miroslav, Sobotka, Jakub, Stetina, Rudolf

“…Sulfur mustard (bis(2-chloroethyl)sulfide; CAS: 505-60-2; abbreviated as HD) is a chemical warfare agent with not well understood mechanism of toxic effect…”
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Parameters of oxidative stress, DNA damage and DNA repair in type 1 and type 2 diabetes mellitus by Pácal, Lukáš, Varva ovská, Jana, Rušavý, Zden k, Lacigová, Silva, Št tina, Rudolf, Racek, Jaroslav, Pomaha ová, Renata, Tanhäuserová, Veronika, Ka ková, Kate ina

“…Objectives: (i) to determine the extent of oxidative stress and DNA damage and repair using a panel of selected markers in patients with type 1 and type 2…”
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Inter-individual differences in repair of DNA base oxidation, measured in vitro with the comet assay by Collins, Andrew R., Dušinská, Mária, Horváthová, Eva, Munro, Eann, Savio, Monica, Štětina, Rudolf

“…There is a need for a reliable, robust and sensitive assay for DNA repair, suitable for use with human lymphocyte samples in molecular epidemiological…”
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Modulation of DNA repair capacity and mRNA expression levels of XRCC1, hOGG1 and XPC genes in styrene-exposed workers by Hanova, Monika, Stetina, Rudolf, Vodickova, Ludmila, Vaclavikova, Radka, Hlavac, Pavel, Smerhovsky, Zdenek, Naccarati, Alessio, Polakova, Veronika, Soucek, Pavel, Kuricova, Miroslava, Manini, Paola, Kumar, Rajiv, Hemminki, Kari, Vodicka, Pavel

“…Decreased levels of single-strand breaks in DNA (SSBs), reflecting DNA damage, have previously been observed with increased styrene exposure in contrast to a…”
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Aspects of oxidative stress in children with Type 1 diabetes mellitus by Varvařovská, Jana, Racek, Jaroslav, Štětina, Rudolf, Sýkora, Josef, Pomahačová, Renata, Rušavý, Zdeněk, Lacigová, Silvie, Trefil, Ladislav, Siala, Konrad, Stožický, František

“…Diabetes mellitus is considered to be one of a rank of free radical diseases. The existence of hyperglycemia produces increased oxidative stress (OS) via…”
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Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant by Vodicka, Pavel, Kumar, Rajiv, Stetina, Rudolf, Musak, Ludovit, Soucek, Pavel, Haufroid, Vincent, Sasiadek, Maria, Vodickova, Ludmila, Naccarati, Alessio, Sedikova, Jana, Sanyal, Somali, Kuricova, Miroslava, Brsiak, Viliam, Norppa, Hannu, Buchancova, Jana, Hemminki, Kari

“…Workers employed in tire plants are exposed to a variety of xenobiotics, such as 1,3‐butadiene (BD), soots containing polycyclic aromatic hydrocarbons, and…”
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The evaluation of oxidative damage of DNA after poisoning with nerve agents by Kassa, Jiri, Stetina, Rudolf

“…The potency of three nerve agents (sarin, soman, tabun) to induce oxidative damage of DNA in lymphocytes, liver and brain during lethal or sublethal poisoning…”
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Induction and repair of DNA cross-links induced by sulfur mustard in the A-549 cell line followed by a comet assay by Jost, Petr, Svobodova, Hana, Stetina, Rudolf

“…•We have optimized the alkaline comet assay method for detection of DNA cross-links and assessing DNA damage repair.•Most of the DNA cross-links induced with…”
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ANTIMUTAGENIC EFFECT OF PHENETHYL ISOTHIOCYANATE by SMERAK, Petr, POLIVKOVA, Zdenka, STETINA, Rudolf, BARTOVA, Jirina, BARTA, Ivo

“…Using the Ames bacterial mutagenicity test, the comet assay, and an in vivo micronucleus test, we investigated the effect of the chemoprotective substance…”
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An investigation of DNA damage and DNA repair in chemical carcinogenesis triggered by small-molecule xenobiotics and in cancer: Thirty years with the comet assay by Vodicka, Pavel, Vodenkova, Sona, Horak, Josef, Opattova, Alena, Tomasova, Kristyna, Vymetalkova, Veronika, Stetina, Rudolf, Hemminki, Kari, Vodickova, Ludmila

“…In the present review we addressed the determination of DNA damage induced by small-molecule carcinogens, considered their persistence in DNA and mutagenicity…”
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Protective potential of different compounds and their combinations with MESNA against sulfur mustard-induced cytotoxicity and genotoxicity by Jost, Petr, Fikrova, Petra, Svobodova, Hana, Pejchal, Jaroslav, Stetina, Rudolf

“…•The efficacy of 13 molecules was tested against sulfur mustard.•The combination of molecules with sodium 2-mercaptoethane sulphonate contributes to enhancing…”
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Application of the comet assay method in clinical studies by Fikrová, Petra, Štětina, Rudolf, Hronek, Miloslav, Hyšpler, Radek, Tichá, Alena, Zadák, Zdeněk

“…Summary The comet assay or single-cell gel electrophoresis (SCGE) assay is now widely accepted as a standard method for assessing DNA damage in individual…”
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Does Neuraxial Anesthesia as General Anesthesia Damage DNA? A Pilot Study in Patients Undergoing Orthopedic Traumatological Surgery by Kucharova, Monika, Astapenko, David, Zubanova, Veronika, Koscakova, Maria, Stetina, Rudolf, Zadak, Zdenek, Hronek, Miloslav

“…The human organism is exposed daily to many endogenous and exogenous substances that are the source of oxidative damage. Oxidative damage is one of the most…”
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Calibration of the comet assay using ionising radiation by Brunborg, Gunnar, Eide, Dag M., Graupner, Anne, Gutzkow, Kristine, Shaposhnikov, Sergey, Kruszewski, Marcin, Sirota, Nikolai, Jones, George D.D., Koppen, Gudrun, Vanhavere, Filip, Møller, Peter, Stetina, Rudolf, Dahl, Hildegunn, Collins, Andrew

“…Several trials have attempted to identify sources of inter-laboratory variability in comet assay results, aiming at achieving more equal responses. Ionising…”
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Inter strand crosslinks in DNA induced in vivo by percutaneous application of sulphur mustard to rats and mice by Richterova, Martina, Stetina, Rudolf, Jost, Petr, Svobodova, Hana, Rehacek, Vit, Kassa, Jiri

“…•Sulphur mustard applied percutaneously rapidly spreads in different organs.•It induces DNA crosslinks in lymphocytes, liver, bone marrow, spleen,…”
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Screening of the chemoprotective effect of 13 compounds and their mixtures with sodium 2-mercaptoethanesulfonate against 2-chloroethyl ethyl sulfide by Jost, Petr, Pejchal, Jaroslav, Kucera, Tomas, Muckova, Lubica, Stetina, Rudolf

“…2-chloroethyl ethyl sulfide (CEES) is a vesicant agent, commonly referred to half mustard due to its ability to form monofunctional adducts with DNA. In this…”
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Shift of oxidants and antioxidants levels in rats as a reaction to exposure to sulfur mustard by Pohanka, Miroslav, Stetina, Rudolf

“…Antixodants as well as oxidants levels were investigated in plasma of rats exposed to sulfur mustard in doses of 0 (control), 5, 20 and 80 mg kg−1 body weight…”
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Calibration of the comet assay using ionising radiation by Brunborg, Gunnar, Eide, Dag Markus, Graupner, Anne, Gutzkow, Kristine Bjerve, Shaposhnikov, Sergey, Kruszewski, Marcin, Sirota, Nikolay, Jones, George D. D, Koppen, Gudrun, Vanhavere, Filip, Møller, Peter, Stetina, Rudolf, Dahl, Hildegunn, Collins, Andrew Richard Sherman

“…Several trials have attempted to identify sources of inter-laboratory variability in comet assay results, aiming at achieving more equal responses. Ionising…”
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