Search Results - "STERNBERG, E"

The Phyre2 web portal for protein modeling, prediction and analysis by Kelley, Lawrence A, Mezulis, Stefans, Yates, Christopher M, Wass, Mark N, Sternberg, Michael J E

“…Phyre2 is a web-based tool for predicting and analyzing protein structure and function. Phyre2 uses advanced remote homology detection methods to build 3D…”
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Protein structure prediction on the Web: a case study using the Phyre server by Kelley, Lawrence A, Sternberg, Michael J E

“…Determining the structure and function of a novel protein is a cornerstone of many aspects of modern biology. Over the past decades, a number of computational…”
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Malaria transmission potential could be reduced with current and future climate change by Murdock, C. C., Sternberg, E. D., Thomas, M. B.

“…Several studies suggest the potential for climate change to increase malaria incidence in cooler, marginal transmission environments. However, the effect of…”
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Missense3D-DB web catalogue: an atom-based analysis and repository of 4M human protein-coding genetic variants by Khanna, Tarun, Hanna, Gordon, Sternberg, Michael J. E., David, Alessia

“…The interpretation of human genetic variation is one of the greatest challenges of modern genetics. New approaches are urgently needed to prioritize variants,…”
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Structure-based prediction of protein allostery by Greener, Joe G, Sternberg, Michael JE

“…•The structure-based prediction of allostery will realise the potential of allostery.•Modern computational methods can help predict allosteric sites and…”
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Utility of diffusion tensor imaging in evaluation of the peritumoral region in patients with primary and metastatic brain tumors by Sternberg, E J, Lipton, M L, Burns, J

“…In the brain, diffusion tensor imaging is a useful tool for defining white matter anatomy, planning a surgical approach to space-occupying lesions, and…”
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Neuroendocrine regulation of autoimmune/inflammatory disease by Sternberg, EM

“…Interactions between the immune and nervous systems play an important role in modulating host susceptibility and resistance to inflammatory disease…”
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Emotional Selection in Memes: The Case of Urban Legends by Heath, Chip, Bell, Chris, Sternberg, Emily

“…This article explores how much memes like urban legends succeed on the basis of informational selection (ie., truth or a moral lesson) & emotional selection…”
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Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice by Silverman, M N, Mukhopadhyay, P, Belyavskaya, E, Tonelli, L H, Revenis, B D, Doran, J H, Ballard, B E, Tam, J, Pacher, P, Sternberg, E M

“…Endogenous glucocorticoids are essential for mobilizing energy resources, restraining inflammatory responses and coordinating behavior to an immune challenge…”
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Insights into protein flexibility: The relationship between normal modes and conformational change upon protein-protein docking by Dobbins, Sara E, Lesk, Victor I, Sternberg, Michael J.E

“…Understanding protein interactions has broad implications for the mechanism of recognition, protein design, and assigning putative functions to uncharacterized…”
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CombFunc: predicting protein function using heterogeneous data sources by Wass, Mark N, Barton, Geraint, Sternberg, Michael J E

“…Only a small fraction of known proteins have been functionally characterized, making protein function prediction essential to propose annotations for…”
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ConFunc—functional annotation in the twilight zone by Wass, Mark N., Sternberg, Michael J. E.

“…Motivation: The success of genome sequencing has resulted in many protein sequences without functional annotation. We present ConFunc, an automated Gene…”
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Automated identification of protein-ligand interaction features using Inductive Logic Programming: a hexose binding case study by A Santos, Jose C, Nassif, Houssam, Page, David, Muggleton, Stephen H, E Sternberg, Michael J

“…There is a need for automated methods to learn general features of the interactions of a ligand class with its diverse set of protein receptors. An appropriate…”
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In Silico Analysis of the Small Molecule Content of Outer Membrane Vesicles Produced by Bacteroides thetaiotaomicron Indicates an Extensive Metabolic Link between Microbe and Host by Bryant, William A, Stentz, Régis, Le Gall, Gwenaelle, Sternberg, Michael J E, Carding, Simon R, Wilhelm, Thomas

“…The interactions between the gut microbiota and its host are of central importance to the health of the host. Outer membrane vesicles (OMVs) are produced…”
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Brain-immune interactions and disease susceptibility by MARQUES-DEAK, A, CIZZA, G, STERNBERG, E

“…Many studies have established the routes by which the immune and central nervous (CNS) systems communicate. This network of connections permits the CNS to…”
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IGSF10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty by Howard, Sasha R, Guasti, Leonardo, Ruiz‐Babot, Gerard, Mancini, Alessandra, David, Alessia, Storr, Helen L, Metherell, Lousie A, Sternberg, Michael JE, Cabrera, Claudia P, Warren, Helen R, Barnes, Michael R, Quinton, Richard, de Roux, Nicolas, Young, Jacques, Guiochon‐Mantel, Anne, Wehkalampi, Karoliina, André, Valentina, Gothilf, Yoav, Cariboni, Anna, Dunkel, Leo

“…Early or late pubertal onset affects up to 5% of adolescents and is associated with adverse health and psychosocial outcomes. Self‐limited delayed puberty (DP)…”
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CAPRI: A Critical Assessment of PRedicted Interactions by Janin, Joël, Henrick, Kim, Moult, John, Eyck, Lynn Ten, Sternberg, Michael J. E., Vajda, Sandor, Vakser, Ilya, Wodak, Shoshana J.

“…CAPRI is a communitywide experiment to assess the capacity of protein‐docking methods to predict protein–protein interactions. Nineteen groups participated in…”
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Automated Prediction of Protein Function and Detection of Functional Sites from Structure by Pazos, Florencio, Michael J. E. Sternberg, Petsko, Gregory A.

“…Current structural genomics projects are yielding structures for proteins whose functions are unknown. Accordingly, there is a pressing requirement for…”
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Utility of plasma volume status in ambulatory patients with pulmonary hypertension by Sternberg, Michael E., Grinnan, Daniel, Gertz, Zachary M.

“…Plasma volume status (PVS) is a noninvasive estimate of intravascular volume status. We studied the utility of PVS to predict short‐term outcomes in patients…”
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Isolation of a small molecule inhibitor of DNA base excision repair by Madhusudan, Srinivasan, Smart, Fiona, Shrimpton, Paul, Parsons, Jason L., Gardiner, Laurence, Houlbrook, Sue, Talbot, Denis C., Hammonds, Timothy, Freemont, Paul A., Sternberg, Michael J. E., Dianov, Grigory L., Hickson, Ian D.

“…The base excision repair (BER) pathway is essential for the removal of DNA bases damaged by alkylation or oxidation. A key step in BER is the processing of an…”
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