Search Results - "STERNBERG, D. W"

KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloproliferative disease associated with a t(5;14)(q33;q32) by LEVINE, R. L, WADLEIGH, M, STERNBERG, D. W, WLODARSKA, I, GALINSKY, I, STONE, R. M, DEANGELO, D. J, GILLILAND, D. Gary, COOLS, J

“…We report the cloning of a novel PDGFRB fusion gene partner in a patient with a chronic myeloproliferative disorder characterized by t(5;14)(q33;q32), who…”
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Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation by Frantsve, Julie, Schwaller, Juerg, Sternberg, David W., Kutok, Jeffery, Gilliland, D. Gary

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Translational insights and overall survival in the U31402-A-U102 study of patritumab deruxtecan (HER3-DXd) in EGFR-mutated NSCLC by Yu, H A, Baik, C, Kim, D-W, Johnson, M L, Hayashi, H, Nishio, M, Yang, J C-H, Su, W-C, Gold, K A, Koczywas, M, Smit, E F, Steuer, C E, Felip, E, Murakami, H, Kim, S-W, Su, X, Sato, S, Fan, P-D, Fujimura, M, Tanaka, Y, Patel, P, Sternberg, D W, Sellami, D, Jänne, P A

“…Human epidermal growth factor receptor 3 (HER3) is broadly expressed in non-small-cell lung cancer (NSCLC) and is the target of patritumab deruxtecan…”
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K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity by Berg, M M, Sternberg, D W, Parada, L F, Chao, M V

“…The rat pheochromocytoma PC12 cell line differentiates into a sympathetic neuronal phenotype upon treatment with either nerve growth factor (NGF) or basic…”
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The Low-Affinity p75 Nerve Growth Factor (NGF) Receptor Mediates NGF- Induced Tyrosine Phosphorylation by Berg, Margaret M., Sternberg, David W., Hempstead, Barbara L., Chao, Moses V.

“…Protein tyrosine phosphorylation is a potential mechanism for initial signaling in PC12 cells during differentiation in response to nerve growth factor (NGF)…”
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Combination of Rapamycin and Protein Tyrosine Kinase (PTK) Inhibitors for the Treatment of Leukemias Caused by Oncogenic PTKs by Mohi, M. Golam, Boulton, Christina, Gu, Ting-Lei, Sternberg, David W., Neuberg, Donna, Griffin, James D., Gilliland, D. Gary, Neel, Benjamin G., Ruderman, Joan V.

“…Abnormal protein tyrosine kinases (PTKs) cause many human leukemias. For example, BCR/ABL causes chronic myelogenous leukemia (CML), whereas FLT3 mutations…”
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Nerve Growth Factor Stimulates Protein Tyrosine Phosphorylation in PC-12 Pheochromocytoma Cells by Miyasaka, Tadayo, Sternberg, David W., Miyasaka, Junko, Sherline, Peter, Saltiel, Alan R.

“…The cellular actions of nerve growth factor (NGF) and epidermal growth factor (EGF) may be mediated by changes in protein phosphorylation. The tyrosine…”
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Treatment of patients with recurrent and primary refractory acute myelogenous leukemia using mitoxantrone and intermediate-dose cytarabine : A pharmacologically based regimen by STERNBERG, D. W, AIRD, W, NEUBERG, D, THOMPSON, L, MACNEILL, K, AMREIN, P, SHULMAN, L. N

“…Although chemotherapy can achieve a high rate of disease remission induction in patients with newly diagnosed acute myelogenous leukemia (AML), patients with…”
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H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor β gene in atypical chronic myeloid leukemia with t(5;10)(q33;q22) by Schwaller, Juerg, Anastasiadou, Ema, Cain, Danielle, Kutok, Jeff, Wojiski, Sarah, Williams, Ifor R., LaStarza, Roberta, Crescenzi, Barbara, Sternberg, David W., Andreasson, Patrick, Schiavo, Roberta, Siena, Salvatore, Mecucci, Cristina, Gilliland, D. Gary

“…The molecular cloning of the t(5;10)(q33;q22) associated with atypical chronic myeloid leukemia (CML) is reported. Fluorescence in situ hybridization (FISH),…”
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Activation of a histone H1 kinase by tyrosine phosphorylation in v‐src‐transformed fibroblasts by Sternberg, D.W., Scholz, G., Fukui, Y., Hanafusa, H.

“…Using anti‐phosphotyrosine immunoaffinity chromatography, we have searched for serine/threonine kinases that are directly regulated by tyrosine phosphorylation…”
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S-methyl glutathione synthesis is catalyzed by the cheR methyltransferase in Escherichia coli by TERWILLIGER, T. C, BOLLAG, G. E, STERNBERG, D. W. JR, KOSHLAND, D. E. JR

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A phase I study evaluating the combination of OSI-906, a dual inhibitor of insulin growth factor-1 receptor (IGF-1R) and insulin receptor (IR) with weekly paclitaxel (PAC) in patients with advanced solid tumors by Harb, W. A., Sessa, C., Hirte, H. W., Kaye, S. B., Simantov, R., Banerjee, S. N., Christinat, A., Sternberg, D. W., Singh, M., Light, R., Poondru, S.

“…Abstract only…”
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Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations by Radomska, Hanna S, Bassères, Daniela S, Zheng, Rui, Zhang, Pu, Dayaram, Tajhal, Yamamoto, Yukiya, Sternberg, David W, Lokker, Nathalie, Giese, Neill A, Bohlander, Stefan K, Schnittger, Susanne, Delmotte, Marie-Hélène, Davis, Roger J, Small, Donald, Hiddemann, Wolfgang, Gilliland, D Gary, Tenen, Daniel G

“…Mutations constitutively activating FLT3 kinase are detected in approximately 30% of acute myelogenous leukemia (AML) patients and affect downstream pathways…”
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Quantitative Proteomic Analysis Using Isobaric Protein Tags Enables Rapid Comparison of Changes in Transcript and Protein Levels in Transformed Cells by Unwin, Richard D, Pierce, Andrew, Watson, Rod B, Sternberg, David W, Whetton, Anthony D

“…Isobaric tags for relative and absolute quantitation, an approach to concurrent, relative quantification of proteins present in four cell preparations, have…”
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NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a by Gu, Ting-Lei, Tothova, Zuzana, Scheijen, Blanca, Griffin, James D., Gilliland, D. Gary, Sternberg, David W.

“…Between 30% and 50% of patients with advanced-stage anaplastic large-cell lymphoma (ALCL) harbor the balanced chromosomal rearrangement t(2;5)(p23;q35), which…”
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The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis by STERNBERG, David W, GILLILAND, D. Gary

“…Human leukemias are frequently associated with the aberrant expression of activated fusion tyrosine kinases or activated protein tyrosine kinases carrying…”
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Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation by Frantsve, J, Schwaller, J, Sternberg, D W, Kutok, J, Gilliland, D G

“…TEL-JAK2 fusion proteins, which are a result of t(9; 12)(p24; p13) translocations associated with human leukemia, activate Stat5 in vitro and in vivo and cause…”
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PD09-03: Phase I/II Study of BKM120 in Combination with Trastuzumab in Patients with HER2 Overexpressing Metastatic Breast Cancer Resistant to Trastuzumab-Containing Therapy by Saura, C, Bendell, J, Jerusalem, G, Graña-Suárez, B, Su, S, Ru, Q, De Buck, S, Devisme, C, Bosch, A, Urruticoechea, A, Beck, JT, DiTomaso, E, Rouyrre, N, Sternberg, DW, Massacesi, C, Hirawat, S, Dirix, L, Baselga, J

“…Introduction: HER2 amplification can activate the phosphatidylinositol-3-kinase (PI3K) pathway in breast cancer. Furthermore, trastuzumab (T) resistance can be…”
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Therapeutic intervention in leukemias that express the activated fms-like tyrosine kinase 3 (FLT3): opportunities and challenges by Sternberg, David W, Licht, Jonathan D

“…PURPOSE OF REVIEWThe fms-like tyrosine kinase 3 (FLT3) receptor tyrosine kinase is now recognized to be a critical mediator in the pathogenesis of myeloid and…”
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The TEL/PDGFbetaR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways by Sternberg, D W, Tomasson, M H, Carroll, M, Curley, D P, Barker, G, Caprio, M, Wilbanks, A, Kazlauskas, A, Gilliland, D G

“…The TEL/PDGFbetaR gene, which encodes a fusion protein containing the ETS-family member TEL fused to the protein-tyrosine kinase domain of the platelet-derived…”
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