Search Results - "STEPHENS, Sue"

Certolizumab Pegol by Goel, Niti, Stephens, Sue

“…Certolizumab pegol (Cimzia®) is currently the only PEGylated anti-TNFα biologic approved for the treatment of rheumatoid arthritis and Crohn disease. The…”
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Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22 by DIJOSEPH, John F, POPPLEWELL, Andrew, ZINKEWICH-PEOTTI, Karen, STEPHENS, Sue, WEIR, Neil, DAMLE, Nitin K, TICKLE, Simon, LADYMAN, Heather, LAWSON, Alastair, KUNZ, Arthur, KHANDKE, Kiran, ARMELLINO, Douglas C, BOGHAERT, Erwin R, HAMANN, Philip R

“…Antibody-targeted chemotherapy with immunoconjugates of calicheamicin is a clinically validated strategy in cancer therapy. This study describes the selection…”
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Differences in cytokine synthesis by the sub‐populations of dendritic cells from afferent lymph by Stephens, Sue A., Brownlie, Joe, Charleston, Bryan, Howard, Chris J.

“…Summary Two phenotypically distinct subpopulations of dendritic cells (SIRPα+ CC81Ag− DC and SIRPα− CC81Ag+ DC) have previously been identified in bovine…”
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Mechanism of action of certolizumab pegol (CDP870): In vitro comparison with other anti‐tumor necrosis factor α agents by Nesbitt, Andrew, Fossati, Gianluca, Bergin, Marianne, Stephens, Paul, Stephens, Sue, Foulkes, Roly, Brown, Derek, Robinson, Martyn, Bourne, Tim

“…Background: Inhibitors of tumor necrosis factor α (TNFα) have demonstrated significant efficacy in chronic inflammatory diseases, including Crohn's disease…”
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Mechanism of action of certolizumab pegol (CDP870): In vitro comparison with other anti-tumor necrosis factor a agents by Nesbitt, Andrew, Fossati, Gianluca, Bergin, Marianne, Stephens, Paul, Stephens, Sue, Foulkes, Roly, Brown, Derek, Robinson, Martyn, Bourne, Tim

“…Background: Inhibitors of tumor necrosis factor (TNF) have demonstrated significant efficacy in chronic inflammatory diseases, including Crohn's disease (CD)…”
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The Use of Surrogate Antibodies to Evaluate the Developmental and Reproductive Toxicity Potential of an Anti-TNFα PEGylated Fab′ Monoclonal Antibody by Wakefield, Ian, Stephens, Sue, Foulkes, Roly, Nesbitt, Andrew, Bourne, Tim

“…Certolizumab pegol (CZP) is a PEGylated Fab′ fragment of a humanized monoclonal immunoglobulin G (IgG)1 antibody that binds to human tumor necrosis factor…”
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Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies by DiJoseph, John F., Armellino, Douglas C., Boghaert, Erwin R., Khandke, Kiran, Dougher, Maureen M., Sridharan, Latha, Kunz, Arthur, Hamann, Philip R., Gorovits, Boris, Udata, Chandrasekhar, Moran, Justin K., Popplewell, Andrew G., Stephens, Sue, Frost, Philip, Damle, Nitin K.

“…Antibody-targeted chemotherapy with gemtuzumab ozogamicin (CMA-676, a CD33-targeted immunoconjugate of N-acetyl-γ-calicheamicin dimethyl hydrazide [CalichDMH],…”
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Investigation of the Pharmacokinetic Properties of Certolizumab Pegol, an Anti-TNF Agent: 1117 by Baker, Mark, Stephens, Sue

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Skin Cancer Surveillance Behaviors Among Childhood Cancer Survivors by Stapleton, Jerod L., Tatum, Kristina L., Devine, Katie A., Stephens, Sue, Masterson, Margaret, Baig, Amna, Hudson, Shawna V., Coups, Elliot J.

“…The risk of developing skin cancer is elevated among childhood cancer survivors (CCS), particularly among those treated with radiation. This survey study…”
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Skin Cancer Surveillance Behaviors Among Childhood Cancer Survivors: Skin Cancer Surveillance Among CCS by Stapleton, Jerod L., Tatum, Kristina L., Devine, Katie A., Stephens, Sue, Masterson, Margaret, Baig, Amna, Hudson, Shawna V., Coups, Elliot J.

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Therapeutic antibody fragments with prolonged in vivo half-lives by Chapman, Andrew P, Antoniw, Pari, Spitali, Mariangela, West, Shauna, Stephens, Sue, King, David J

“…Antibody fragments can be isolated rapidly using techniques such as phage display and can be expressed to high levels in microbial systems. However, to date…”
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The use of surrogate antibodies to evaluate the developmental and reproductive toxicity potential of an anti-TNFalpha PEGylated Fab' monoclonal antibody by Wakefield, Ian, Stephens, Sue, Foulkes, Roly, Nesbitt, Andrew, Bourne, Tim

“…Certolizumab pegol (CZP) is a PEGylated Fab' fragment of a humanized monoclonal immunoglobulin G (IgG)1 antibody that binds to human tumor necrosis factor…”
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Paraneoplastic Pemphigus with Bronchiolitis Obliterans in a Child by Mar, Winnie A., Glaesser, Robin, Struble, Kristin, Stephens‐Groff, Sue, Bangert, Jerry, Hansen, Ronald C.

“…: Paraneoplastic pemphigus (PNP) is a rare blistering autoimmune disease associated with an underlying neoplasm, mucous membrane erosions, and occasionally…”
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Efficacy and Safety of Certolizumab Pegol Do Not Appear To Be Affected by Neutralizing Antibodies in Patients with Crohnʼs Disease: 971 by Stephens, Sue, Bloomfield, Ralph, Devine, Donna M., Nesbitt, Andrew M.

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Placental Transfer and Accumulation in Milk of the Anti-TNF Antibody TN3 in Rats: Immunoglobulin G1 Versus PEGylated Fabʼ by Nesbitt, Andrew M., Brown, Derek T., Stephens, Sue, Foulkes, Roly

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In Patients Suffering from Crohnʼs Disease, No Cross Reaction between Antibodies to Infliximab and Certolizumab Pegol Was Detected: 1118 by Nesbitt, Andrew M., Vetterlein, Olivia M., Kopotsha, Tim M.T., Brown, Derek T., Stephens, Sue

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Difference in cytokine synthesis by the sub-populations of dendritic cells from afferent lymph by Stephens, Sue A, Brownlee, Joe, Charleston, Bryan, Howard, Chris J

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CDP571, a humanized antibody to human tumor necrosis factor-alpha: Safety, pharmacokinetics, immune response, and influence of the antibody on cytokine concentrations in patients with septic shock by Dhainaut, Jean-Francois A, Vincent, Jean-Louis, Richard, Christian, Lejeune, Philippe, Martin, Claude, Fierobe, Lisiane, Stephens, Sue, Ney, Ursula M, Sopwith, Mark

“…OBJECTIVES To determine the safety of a ``humanized'' antibody to human anti-tumor necrosis factor-alpha (TNF-alpha) in patients with septic shock, and to…”
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Health care professionals referred for treatment of alcohol and drug problems by Gossop, Michael, Stephens, Sue, Stewart, Duncan, Marshall, Jane, Bearn, Jennifer, Strang, John

“…— This study reports on 62 health care professionals referred to a specialist drug and alcohol treatment service. Most patients used more than one type of…”
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In situ expression of tumor necrosis factor-alpha, interferon-gamma, and interleukin-2 receptors in renal allograft biopsies by Noronha, I L, Eberlein-Gonska, M, Hartley, B, Stephens, S, Cameron, J S, Waldherr, R

“…The production and release of cytokines and their receptors are of critical importance in mediating graft injury. In order to evaluate the expression of…”
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