Search Results - "STEPHENS, J"

Gut microbiota influence in type 2 diabetes mellitus (T2DM) by Cunningham, A. L, Stephens, J. W, Harris, D. A

“…Abstract A strong and expanding evidence base supports the influence of gut microbiota in human metabolism. Altered glucose homeostasis is associated with…”
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Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers by Goodman, Aaron M, Kato, Shumei, Bazhenova, Lyudmila, Patel, Sandip P, Frampton, Garrett M, Miller, Vincent, Stephens, Philip J, Daniels, Gregory A, Kurzrock, Razelle

“…Immunotherapy induces durable responses in a subset of patients with cancer. High tumor mutational burden (TMB) may be a response biomarker for PD-1/PD-L1…”
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Catenanes: Fifty Years of Molecular Links by Gil-Ramírez, Guzmán, Leigh, David A., Stephens, Alexander J.

“…Half a century after Schill and Lüttringhaus carried out the first directed synthesis of a [2]catenane, a plethora of strategies now exist for the construction…”
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A review on gut microbiota: a central factor in the pathophysiology of obesity by Cunningham, A L, Stephens, J W, Harris, D A

“…Obesity and its complications constitute a substantial burden. Considerable published research describes the novel relationships between obesity and gut…”
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A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal by Sun, James X, He, Yuting, Sanford, Eric, Montesion, Meagan, Frampton, Garrett M, Vignot, Stéphane, Soria, Jean-Charles, Ross, Jeffrey S, Miller, Vincent A, Stephens, Phil J, Lipson, Doron, Yelensky, Roman

“…A key constraint in genomic testing in oncology is that matched normal specimens are not commonly obtained in clinical practice. Thus, while well-characterized…”
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ECD cotton effect approximated by the Gaussian curve and other methods by Stephens, Philip J., Harada, Nobuyuki

“…To determine the absolute configuration of chiral compounds, theoretical calculations of ECD spectra have been extensively carried out, where the shape of…”
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Markerless tracking of an entire honey bee colony by Bozek, Katarzyna, Hebert, Laetitia, Portugal, Yoann, Mikheyev, Alexander S., Stephens, Greg J.

“…From cells in tissue, to bird flocks, to human crowds, living systems display a stunning variety of collective behaviors. Yet quantifying such phenomena first…”
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Speaker–listener neural coupling underlies successful communication by Stephens, Greg J., Silbert, Lauren J., Hasson, Uri, Gross, Charles G.

“…Verbal communication is a joint activity; however, speech production and comprehension have primarily been analyzed as independent processes within the…”
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ER-to-Golgi trafficking of procollagen in the absence of large carriers by McCaughey, Janine, Stevenson, Nicola L, Cross, Stephen, Stephens, David J

“…Secretion and assembly of collagen are fundamental to the function of the extracellular matrix. Defects in the assembly of a collagen matrix lead to…”
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Adaptive, locally linear models of complex dynamics by Costa, Antonio C., Ahamed, Tosif, Stephens, Greg J.

“…The dynamics of complex systems generally include high-dimensional, nonstationary, and nonlinear behavior, all of which pose fundamental challenges to…”
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Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines by Stephens, Alexander J, Burgess-Brown, Nicola A, Jiang, Shisong

“…Peptide-based cancer vaccines rely upon the strong activation of the adaptive immune response to elicit its effector function. They have shown to be highly…”
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Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies by Lipson, Doron, Capelletti, Marzia, Yelensky, Roman, Otto, Geoff, Parker, Alex, Jarosz, Mirna, Curran, John A, Balasubramanian, Sohail, Bloom, Troy, Brennan, Kristina W, Donahue, Amy, Downing, Sean R, Frampton, Garrett M, Garcia, Lazaro, Juhn, Frank, Mitchell, Kathy C, White, Emily, White, Jared, Zwirko, Zac, Peretz, Tamar, Nechushtan, Hovav, Soussan-Gutman, Lior, Kim, Jhingook, Sasaki, Hidefumi, Kim, Hyeong Ryul, Park, Seung-il, Ercan, Dalia, Sheehan, Christine E, Ross, Jeffrey S, Cronin, Maureen T, Jänne, Pasi A, Stephens, Philip J

“…Using high-coverage targeted next-generation sequencing, this report provides a catalog of genetic alterations in colorectal and lung cancers, identifying…”
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Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study by Sicklick, Jason K., Kato, Shumei, Okamura, Ryosuke, Schwaederle, Maria, Hahn, Michael E., Williams, Casey B., De, Pradip, Krie, Amy, Piccioni, David E., Miller, Vincent A., Ross, Jeffrey S., Benson, Adam, Webster, Jennifer, Stephens, Philip J., Lee, J. Jack, Fanta, Paul T., Lippman, Scott M., Leyland-Jones, Brian, Kurzrock, Razelle

“…Cancer treatments have evolved from indiscriminate cytotoxic agents to selective genome- and immune-targeted drugs that have transformed the outcomes of some…”
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Active sampling and decision making in Drosophila chemotaxis by Gomez-Marin, Alex, Stephens, Greg J., Louis, Matthieu

“…The ability to respond to chemical stimuli is fundamental to the survival of motile organisms, but the strategies underlying odour tracking remain poorly…”
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WormPose: Image synthesis and convolutional networks for pose estimation in C. elegans by Hebert, Laetitia, Ahamed, Tosif, Costa, Antonio C, O'Shaughnessy, Liam, Stephens, Greg J

“…An important model system for understanding genes, neurons and behavior, the nematode worm C. elegans naturally moves through a variety of complex postures,…”
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An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101 by Doebele, Robert C, Davis, Lara E, Vaishnavi, Aria, Le, Anh T, Estrada-Bernal, Adriana, Keysar, Stephen, Jimeno, Antonio, Varella-Garcia, Marileila, Aisner, Dara L, Li, Yali, Stephens, Philip J, Morosini, Deborah, Tuch, Brian B, Fernandes, Michele, Nanda, Nisha, Low, Jennifer A

“…Oncogenic TRK fusions induce cancer cell proliferation and engage critical cancer-related downstream signaling pathways. These TRK fusions occur rarely, but in…”
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Physical and geochemical responses to bottom trawling on naturally disturbed sediments in the eastern Bering Sea by Stephens, J Drew, McConnaughey, Robert A

“…Abstract Recent concerns that commercial bottom trawling can contribute to a significant release of sequestered marine carbon have highlighted a need for…”
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Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden by Chalmers, Zachary R, Connelly, Caitlin F, Fabrizio, David, Gay, Laurie, Ali, Siraj M, Ennis, Riley, Schrock, Alexa, Campbell, Brittany, Shlien, Adam, Chmielecki, Juliann, Huang, Franklin, He, Yuting, Sun, James, Tabori, Uri, Kennedy, Mark, Lieber, Daniel S, Roels, Steven, White, Jared, Otto, Geoffrey A, Ross, Jeffrey S, Garraway, Levi, Miller, Vincent A, Stephens, Phillip J, Frampton, Garrett M

“…High tumor mutational burden (TMB) is an emerging biomarker of sensitivity to immune checkpoint inhibitors and has been shown to be more significantly…”
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Biliary cancer: Utility of next‐generation sequencing for clinical management by Javle, Milind, Bekaii‐Saab, Tanios, Jain, Apurva, Wang, Ying, Kelley, Robin Katie, Wang, Kai, Kang, Hyunseon C., Catenacci, Daniel, Ali, Siraj, Krishnan, Sunil, Ahn, Daniel, Bocobo, Andrea Grace, Zuo, Mingxin, Kaseb, Ahmed, Miller, Vincent, Stephens, Philip J., Meric‐Bernstam, Funda, Shroff, Rachna, Ross, Jeffrey

“…BACKGROUND Biliary tract cancers (BTCs) typically present at an advanced stage, and systemic chemotherapy is often of limited benefit. METHODS Hybrid…”
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Does modulation of the endocannabinoid system have potential therapeutic utility in cerebellar ataxia? by Stephens, G. J.

“…Cerebellar ataxias represent a spectrum of disorders which are, however, linked by common symptoms of motor incoordination and typically associated with…”
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