Search Results - "STEPCHENKO, A. G"

RNA editing in eukaryotic genome expression by Pankratova, E. V, Stepchenko, A. G

“…The present review surveys the available data on the involvement of adenine deamination in RNA molecules in the formation of structurally and functionally…”
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POU2F1 (Oct-1) Differently Autoregulates the Alternative Promoters of Its Own Gene by Binding to Different Regulatory Sites by Pankratova, E. V., Portseva, T. N., Makarova, A. A., Lyanova, B. M., Georgieva, S. G., Stepchenko, A. G.

“…The POU2F1 gene, which plays an important role in regulating the mammalian genome and development, has both a ubiquitous (U) and a tissue-specific (L) promoter…”
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Multiple Interactions of the Oct-1 (POU2F1) Transcription Factor with PORE and MORE Sites by Stepchenko, A. G., Georgieva, S. G., Pankratova, E. V.

“…The Oct-1 (POU2F1) transcription factor is one of the most important regulatory proteins in humans and other mammals. An increase in Oct-1 aids the resistance…”
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Reduced Expression of the Tissue-Specific Oct-1L Isoform Exerts an Antitumor Effect on Namalwa Burkitt’s Lymphoma Cells by Portseva, T. N., Kotnova, A. P., Bulavkina, E. V., Makarova, A. A., Georgieva, S. G., Stepchenko, A. G., Pankratova, E. V.

“…— Increased expression levels of the Oct-1 transcription factor is considered to be one of the key markers of poor cancer prognosis. In addition to the…”
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Transcription factor-binding sites responsible for NO-dependent repression of the histone H2B promoter by Pankratova, E. V, Manuylova, E. A, Stepchenko, A. G

“…Nitric oxide (NO) is an important signaling molecule with diverse actions in a wide variety of tissues. NO is a well-known inhibitor of cell growth, DNA…”
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The Emergence of a New Isoform of POU2F1 in Primates through the Use of Egoistic Mobile Genetic Elements by Lyanova, B. M., Kotnova, A. P., Makarova, A. A., Ilyin, Yu. V., Georgieva, S. G., Stepchenko, A. G., Pankratova, E. V.

“…The emergence of new genes and functions is of paramount importance in the emergence of new animal species. For example, the insertion of the mobile element…”
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5-Azacytidine Suppresses the Expression of Tissue-Specific Oct-1 Isoform in Namalwa Burkitt’s Lymphoma Cell Culture by Kotnova, A. P., Stepchenko, A. G., Ilyin, Yu. V., Georgieva, S. G., Pankratova, E. V.

“…Overexpression of the transcription factor POU2F1 (Oct-1) increases the malignant potential of the tumor and determines the unfavorable prognosis for both…”
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GSK3 Kinase Inhibitor, CHIR, Suppress Transcription of Tissue Specific POU2F1 Isoform in Burkitt Namalwa Lymphoma Cells by Pankratova, E. V., Portseva, T. N., Makarova, A. A., Ilyin, Yu. V., Stepchenko, A. G., Georgieva, S. G.

“…POU2F1 (Oct-1) is a transcription factor, the overexpression of which is found in many human malignant tumors; a significant increase in its level in cells…”
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Differentiation of IMR32 Neuroblastoma Is Accompanied by a Global Change in the Transcriptome by Stepchenko, A. G., Portseva, T. N., Ilyin, Yu. V., Georgieva, S. G., Pankratova, E. V.

“…Neuroblastoma is one of the most common cancers in infants and is often multidrug-resistant. One of the methods of treating neuroblastomas is to create…”
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Differentiation of Monocytic Cells Is Accompanied by a Change in the Expression of the Set of Oct-1 Isoforms by Stepchenko, A. G., Lyanova, B. M., Krylova, I. D., Ilyin, Yu. V., Georgieva, S. G., Pankratova, E. V.

“…Changes in the expression level of Oct-1A, Oct-1L, Oct-1X, and Oct-1Z isoforms and CD14 surface antigen during differentiation of HL-60 monocytic cells induced…”
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Thapsigargin, Inhibitor of Sarco-Endoplasmic Ca2+-ATPase, Effectively Suppresses the Expression of S100A4 Protein in Human Breast Cancer Cell Line by Kotnova, A. P., Lyanova, B. M., Dukhanina, E. A., Portseva, T. N., Ilyin, Yu. V., Georgieva, S. G., Stepchenko, A. G., Pankratova, E. V.

“…Thapsigargin (SERCA ATPase inhibitor) inhibited the S100A4 metastatic marker expression in MDA-MB231 breast cancer cells. We found that S100A4 gene…”
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The nucleotide sequence of mouse OCT-1 cDNA by STEPCHENKO, A. G

“…Here we report the isolation and characterization of a cDNA encoding mouse Oct-1, the ubiquitously expressed octamer-binding protein. The cDNA was constructed…”
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Increased level of Oct-1 protein in tumor cells modulates cellular response to anticancer drugs by Portseva, T. N., Pankratova, E. V., Stepchenko, A. G., Georgieva, S. G.

“…The effect of overexpression of Oct-1 protein isoforms on the cell response to two anticancer drugs camptothecin and dexamethasone was studied. The effect of…”
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Involvement of transcription factor Oct-1 in the regulation of JAK–STAT signaling pathway in cells of Burkitt lymphoma by Pankratova, E. V., Stepchenko, A. G., Krylova, I. D., Portseva, T. N., Georgieva, S. G.

“…We studied the role of transcription factor Oct-1 in the regulation of expression of genes of the JAK–STAT signaling pathway in the Namalwa Burkitt’s lymphoma…”
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Transcription factor Oct-1 stimulates the release of Mts1/S100A4 protein by the cancer cells by Portseva, T. N., Brechalov, A. V., Dukhanina, E. A., Stepchenko, A. G., Pankratova, E. V., Georgieva, S. G.

“…The effect of the transcription factor Oct-1 (POU2F1) on the expression of the tumor cell marker metastasin (Mts1/S100A4) was studied. Comparative analysis of…”
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New mRNA isoform of Oct-1 transcription factor is transcribed from alternative promoter by Krylova, I. D., Portseva, T. N., Georgieva, S. G., Stepchenko, A. G., Pankratova, E. V.

“…The Oct-1 transcription factor belongs to a family of highly conserved POU domain proteins that participate in the regulation of housekeeping and…”
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Noncanonical Oct-sequences are targets for mouse Oct-2B transcription factor by Stepchenko, A.G.

“…We have suggested a random modification method for determining preferable binding sites of a DNA-binding protein and applied this method to the Oct-2B…”
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New alternative promoter in regulation of the oct-1 human gene transcription by Portseva, T. N., Krylova, I. D., Georgieva, S. G., Stepchenko, A. G., Pankratova, E. V.

“…For the first time, the presence of a new alternative promoter in the gene of the oct-1 transcription factor from which a previously unknown mRNA isoform…”
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Cell differentiation in vitro and the expression of Oct-2 protein and oct-2 RNA by Pankratova, E.V., Sytina, E.V., Stepchenko, A.G.

“…Expression of the oct-2 gene was studied in mouse tissues and during in vitro differentiation of embryocarcinoma PCC4, mouse neuroblastoma Neuro2A and NB41A3…”
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Allelic variants of rearranged immunoglobulin heavy and light chain genes in hybridoma PTF-02 and parent myeloma by DEYEV, S. M, URAKOV, D. N, STEPCHENKO, A. G, POLANOVSKY, O. L

“…The hybridoma PTF-02 secretes an antibody against pig transferrin. Rearranged genes for heavy and light immunoglobulin chains have been studied in the genomes…”
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