Search Results - "STENGARD, J. H"

Variation in 5' Promoter Region of the APOE gene Contributes to Predicting Ischemic Heart Disease (IHD) in the Population at Large: the Copenhagen City Heart Study by Stengård, J. H., Frikke‐Schmidt, R., Tybjærg‐Hansen, A., Nordestgaard, B.G., Sing, C.F.

“…Summary The objective of this study was to evaluate whether an increased hazard of developing ischemic heart disease (IHD) is associated with any of the three…”
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An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E by STENGARD, J. H, WEISS, K. M, SING, C. F

“…Three common alleles, epsilon2, epsilon3, and epsilon4, of the gene coding for apolipoprotein E (apoE) have been identified as predictors of interindividual…”
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Hypertension and overweight associated with hyperinsulinaemia and glucose tolerance : a longitudinal study of the Finnish and Dutch cohorts of the Seven Countries Study by FESKENS, E. J. M, TUOMILEHTO, J, STENGARD, J. H, PEKKANEN, J, NISSINEN, A, KROMHOUT, D

“…To elucidate the role of hypertension as part of the insulin resistance syndrome, the longitudinal relationships of hypertension and overweight with…”
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Utility of the Arg/Gln polymorphism of the factor VII (FVII) gene, serum lipid levels and body mass index in the prediction of the FVII:C and FVII:Ag in North Karelia; a cross-sectional and prospective study by Stengård, J H, Salomaa, V, Rasi, V, Vahtera, E, Ehnholm, C, Krusius, T, Perola, M, Vartiainen, E

“…The arginine/glutamine (Arg/Gln) polymorphism of the factor VII (FVII) gene is associated with variation in coagulation activity (FVII:C) and antigen…”
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Genes, Environment, and Cardiovascular Disease by Sing, Charles F, Stengård, Jari H, Kardia, Sharon L.R

“…ABSTRACT—In this essay, we call to attention what every medical researcher knows about the etiology of cardiovascular disease but most deny, or choose to…”
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Apolipoprotein E polymorphism, Alzheimer's disease and vascular dementia among elderly Finnish men by Stengård, J H, Pekkanen, J, Sulkava, R, Ehnholm, C, Erkinjuntti, T, Nissinen, A

“…An association between late-onset Alzheimer's disease, vascular dementia and the common polymorphic alleles of the gene coding for apolipoprotein E, epsilon 2,…”
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Utility of the predictors of coronary heart disease mortality in a longitudinal study of elderly Finnish men aged 65 to 84 years is dependent on context defined by Apo E genotype and area of residence by Stengård, Jari H, Kardia, Sharon L, Tervahauta, Markku, Ehnholm, Christian, Nissinen, Aulikki, Sing, Charles F

“…A common assumption underlying most genetic studies is that individuals with different genotypes respond similarly to exposure to internal (epigenetic and…”
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A biometrical study of the relationship between sodium-lithium countertransport and triglycerides by STENGÅRD, J. H., ZERBA, K. E., TURNER, S. T., SING, C. F.

“…We addressed the question: Is there evidence that allelic variation in a single unmeasured gene that has a large effect on maximal activity of erythrocyte…”
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Contributions of 18 Additional DNA Sequence Variations in the Gene Encoding Apolipoprotein E to Explaining Variation in Quantitative Measures of Lipid Metabolism by Stengård, Jari H., Clark, Andrew G., Weiss, Kenneth M., Kardia, Sharon, Nickerson, Deborah A., Salomaa, Veikko, Ehnholm, Christian, Boerwinkle, Eric, Sing, Charles F.

“…Apolipoprotein E (ApoE) is a major constituent of many lipoprotein particles. Previous genetic studies have focused on six genotypes defined by three alleles,…”
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Evidence for Non‐additive Influence of Single Nucleotide Polymorphisms within the Apolipoprotein E Gene by Hamon, S. C., Stengard, J. H., Clark, A. G., Salomaa, V., Boerwinkle, E., Sing, C. F.

“…Summary We analyzed 13 single nucleotide polymorphisms (SNPs) within the apolipoprotein E (APOE) gene, to identify pairs of SNPs that interact in a…”
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Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly finnish men by STENGARD, J. H, ZERBA, K. E, PEKKANEN, J, EHNHOLM, C, NISSINEN, A, SING, C. F

“…There is ample evidence from cross-sectional studies of an association between allelic variation of the gene coding for apolipoprotein E (apoE) and…”
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Effects of medroxyprogesterone acetate on liver glucose metabolism in rats with streptozotocin induced diabetes mellitus by Stengård, J H, Saarni, H U, Rautio, A, Knip, M, Stenbäck, F, Sotaniemi, E A

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The effects of scale: variation in the APOA1/C3/A4/A5 gene cluster by FULLERTON, Stephanie M, BUCHANAN, Anne V, NICKERSON, Deborah A, WEISS, Kenneth M, SONPAR, Vibhor A, TAYLOR, Scott L, SMITH, Joshua D, CARLSON, Christopher S, SALOMAA, Veikko, STENGARD, Jari H, BOERWINKLE, Eric, CLARK, Andrew G

“…While there is considerable appeal to the idea of selecting a few SNPs to represent all, or much, of the DNA sequence variability in a local chromosomal…”
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Genotyping of human cytochrome P450 2A6 (CYP2A6), a nicotine C-oxidase by Oscarson, Mikael, Gullstén, Harriet, Rautio, Arja, Bernal, Maria Luisa, Sinues, Blanca, Dahl, Marja-Liisa, Stengård, Jari H, Pelkonen, Olavi, Raunio, Hannu, Ingelman-Sundberg, Magnus

“…Cytochrome P450 2A6 (CYP2A6) is a polymorphic enzyme responsible for the oxidation of certain precarcinogens and drugs and is the major nicotine C-oxidase. The…”
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Diabetes mellitus, impaired glucose tolerance and mortality among elderly men: the Finnish cohorts of the Seven Countries Study by Stengård, J H, Tuomilehto, J, Pekkanen, J, Kivinen, P, Kaarsalo, E, Nissinen, A, Karvonen, M J

“…We studied the association of glucose intolerance with total and cause-specific mortality during a 5-year follow-up of 637 elderly Finnish men aged 65 to 84…”
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Hepatic drug metabolism and the activities of NADPH generating enzymes and glucose-6-phosphatase in phenobarbital treated genetically obese (ob/ob) mice by Stengard, J H, Saarni, H U, Karvonen, R I, Lahtela, J T, Kärki, N T, Stenbäck, F, Sotaniemi, E A

“…We aim to evaluate the effects of phenobarbital (PB) on the liver drug metabolism, NADPH production capacity and terminal gluconeogenic enzyme,…”
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Apolipoprotein E Variation at the Sequence Haplotype Level: Implications for the Origin and Maintenance of a Major Human Polymorphism by Fullerton, Stephanie M., Clark, Andrew G., Weiss, Kenneth M., Nickerson, Deborah A., Taylor, Scott L., Stengård, Jari H., Salomaa, Veikko, Vartiainen, Erkki, Perola, Markus, Boerwinkle, Eric, Sing, Charles F.

“…Three common protein isoforms of apolipoprotein E (apoE), encoded by the η2, η3, and η4 alleles of the APOE gene, differ in their association with…”
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A comparison of the effects of phenobarbital and medroxyprogesterone acetate on drug and glucose metabolism in rats with chemical liver injury by Stengård, J H

“…The effects of medroxyprogesterone acetate (MPA) and phenobarbital (PB) on hepatic glucose and drug metabolism were investigated in male rats after liver…”
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Effects of enzyme induction therapy on glucose and drug metabolism in obese mice model of non-insulin dependent diabetes mellitus by Karvonen, I, Stengård, J H, Huupponen, R, Stenbäck, F G, Sotaniemi, E A

“…We evaluated the effects of phenobarbital, an inducer, on plasma glucose and serum immunoreactive insulin levels and on hepatic glucose and drug metabolism…”
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Time dependent effects of medroxyprogesterone acetate on hepatic ultrastructure in rats by Stengård, J H, Stenbäck, F, Saarni, H U, Rautio, A, Sotaniemi, E A

“…The present study demonstrates that MPA treatment may alter liver ultrastructure in rats. This was seen as a slight cytoplasmic vacuolization in light…”
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