First experience with endovascular ultrasound renal denervation for the treatment of resistant hypertension

To evaluate a novel modality utilising ultrasound for renal denervation designed to reduce the duration of the intervention as well as to increase the consistency of the clinical outcome. Eleven consecutive patients suffering from resistant hypertension as defined by the ESH-ESC guidelines were trea...

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Bibliographic Details
Published in:	EuroIntervention Vol. 8; no. 1; pp. 57 - 61
Main Authors:	MABIN, Tom, SAPOVAL, Marc, CABANE, Vincent, STEMMETT, Joanne, IYER, Mano
Format:	Journal Article
Language:	English
Published:	Toulouse Société Europa Edition 01-05-2012
Subjects:	Adult Aged Aged, 80 and over Antihypertensive Agents - therapeutic use Arterial hypertension. Arterial hypotension Autonomic Denervation - adverse effects Autonomic Denervation - methods Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Drug Resistance Endovascular Procedures - adverse effects Feasibility Studies Female Humans Hypertension - physiopathology Hypertension - therapy Kidney - blood supply Kidney - innervation Male Medical sciences Middle Aged South Africa Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Treatment Outcome Ultrasonic Therapy - adverse effects South Africa Sonography Hypertension Resistance Experience Treatment renal denervation Cardiovascular disease Endovascular route Ultrasound resistant hypertension Kidney Denervation
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Summary:	To evaluate a novel modality utilising ultrasound for renal denervation designed to reduce the duration of the intervention as well as to increase the consistency of the clinical outcome. Eleven consecutive patients suffering from resistant hypertension as defined by the ESH-ESC guidelines were treated by transcatheter renal denervation using the CE-marked PARADISE™ technology (ReCor Medical, Ronkonkoma, NY, USA). An average of 5.1 ultrasound emissions were delivered in each subject for a total denervation duration of less than four minutes and the treatment was well tolerated by all patients. Both office and home blood pressure measurements showed an immediate, significant and sustained decrease in blood pressure. Three-month results were comparable to published data on radiofrequency renal denervation with an average reduction in office and home blood pressure of -36/-17 mmHg and -22/-12 mmHg, respectively. Ultrasound renal denervation appears to be a safe and effective treatment for resistant hypertension and further studies will be performed to confirm these preliminary results.
ISSN:	1774-024X 1969-6213
DOI:	10.4244/EIJV8I1A10