Search Results - "STEINIJANS, V. W."

Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma by Ukena, D, Harnest, U, Sakalauskas, R, Magyar, P, Vetter, N, Steffen, H, Leichtl, S, Rathgeb, F, Keller, A, Steinijans, VW

“…The anti-asthmatic effects of theophylline may supplement those of inhaled steroids in asthma. The aim of the present trial was to study how the addition of…”
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A Dose-dependent Effect of the Novel Inhaled Corticosteroid Ciclesonide on Airway Responsiveness to Adenosine-5'-Monophosphate in Asthmatic Patients by TAYLOR, DAVID A, JENSEN, MARIANNE W, KANABAR, VARSHA, ENGELSTATTER, RENATE, STEINIJANS, VOLKER W, BARNES, PETER J, O'CONNOR, BRIAN J

“…Inhaled corticosteroids decrease airway responsiveness in asthma partly through suppression of airway inflammation. We have previously demonstrated that…”
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A distribution-free procedure for the statistical analysis of bioequivalence studies by Hauschke, D, Steinijans, V W, Diletti, E

“…In bioequivalence assessment, the consumer risk of erroneously accepting bioequivalence is of primary concern. In order to control the consumer risk, the…”
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Lack of pharmacokinetic drug-drug interaction between ciclesonide and erythromycin by Nave, R, Drollmann, A, Steinijans, V W, Zech, K, Bethke, T D

“…To investigate whether systemic exposure to desisobutyrylciclesonide (des-CIC) (the pharmacologically active metabolite of ciclesonide) and erythromycin are…”
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Pharmacokinetics of pantoprazole in man by Huber, R, Hartmann, M, Bliesath, H, Lühmann, R, Steinijans, V W, Zech, K

“…The proton pump inhibitor pantoprazole is a substituted benzimidazole sulphoxide for the treatment of acid-related gastrointestinal diseases such as reflux…”
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Sample size determination for bioequivalence assessment by means of confidence intervals by Diletti, E, Hauschke, D, Steinijans, V W

“…The statistical analysis of bioequivalence assessment has been consolidated in recent years through the work of Schuirmann [1987], Westlake [1988] and Hauschke…”
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Lack of pharmacokinetic interaction as an equivalence problem by Steinijans, V W, Hartmann, M, Huber, R, Radtke, H W

“…The demonstration that concomitant administration of drug B does not affect the pharmacokinetics of drug A can be adequately handled as an equivalence problem…”
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Differences in pH-dependent activation rates of substituted benzimidazoles and biological in vitro correlates by Kromer, W, Krüger, U, Huber, R, Hartmann, M, Steinijans, V W

“…Gastric proton pump inhibitors (PPIs) are substituted benzimidazole prodrugs that require an acid-induced activation. Its rate depends on the reactivity of the…”
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Bronchodilatory effect of inhaled zardaverine, a phosphodiesterase III and IV inhibitor, in patients with asthma by Brunnée, T, Engelstätter, R, Steinijans, V W, Kunkel, G

“…Zardaverine is a newly developed selective phosphodiesterase III and IV inhibitor. This study investigates the bronchodilatory properties of zardaverine,…”
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Lack of pharmacokinetic interaction of pantoprazole with diazepam in man by GUGLER, R., HARTMANN, M., RUDI, J., BROD, I., HUBER, R., STEINIJANS, V. W., BLIESATH, H., WURST, W., KLOTZ, U.

“…Pantoprazole, a substituted benzimidazole, is a potent and well tolerated inhibitor of the gastric H+,K+‐ATPase with a low potential to inhibit cytochrome…”
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Presentation of results from bioequivalence studies by Sauter, R, Steinijans, V W, Diletti, E, Böhm, A, Schulz, H U

“…Based on general guidelines and requirements for the design and analysis of bioequivalence studies, specific recommendations are made for the presentation of…”
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Update on the statistical analysis of bioequivalence studies by Steinijans, V W, Hauschke, D

“…Statistical methods to assess bioequivalence of a test and a reference formulation are reviewed with emphasis on the distribution of bioequivalence…”
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Pantoprazole does not interact with the pharmacokinetics of carbamazepine by Huber, R, Bliesath, H, Hartmann, M, Steinijans, V W, Koch, H, Mascher, H, Wurst, W

“…Pantoprazole is a H+/K+-ATPase inhibitor with a minimized potential of interaction with the cytochrome P450 system. Imidazole derivatives such as cimetidine…”
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Pharmacokinetics of pantoprazole in man by Huber, R, Hartmann, M, Bliesath, H, Lühmann, R, Steinijans, V W, Zech, K

“…The proton pump inhibitor pantoprazole is a substituted benzimidazole sulphoxide for the treatment of acid-related gastrointestinal diseases such as reflux…”
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Lacking effect of grapefruit juice on theophylline pharmacokinetics by Fuhr, U, Maier, A, Keller, A, Steinijans, V W, Sauter, R, Staib, A H

“…Grapefruit juice inhibits the biotransformation of several drugs, including caffeine (23% clearance reduction), which is metabolized by the cytochrome P450…”
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Pantoprazole lacks induction of CYP1A2 activity in man by Hartmann, M, Zech, K, Bliesath, H, Steinijans, V W, Koch, H, Wurst, W, Mascher, H

“…This drug-drug interaction study investigated the potential influence of the proton pump inhibitor pantoprazole on the CYP1A2 activity as assessed by urinary…”
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Interobserver agreement: Cohen's kappa coefficient does not necessarily reflect the percentage of patients with congruent classifications by Steinijans, V W, Diletti, E, Bömches, B, Greis, C, Solleder, P

“…A widely accepted approach to evaluate interrater reliability for categorical responses involves the rating of n subjects by at least 2 raters. Frequently,…”
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Sample size determination for bioequivalence assessment by means of confidence intervals by Diletti, E, Hauschke, D, Steinijans, V W

“…The statistical analysis of bioequivalence assessment has been consolidated in recent years through the work of Schuirmann [1987], Westlake [1988] and Hauschke…”
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Equivalence concepts in clinical trials by STEINIJANS, V. W, NEUHÄUSER, M, BRETZ, F

“…According to the recent ICH E9 Guidance Statistical Principles for Clinical Trials, efficacy is most convincingly established by demonstrating superiority to…”
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Reference tables for the intrasubject coefficient of variation in bioequivalence studies by Steinijans, V W, Sauter, R, Hauschke, D, Diletti, E, Schall, R, Luus, H G, Elze, M, Blume, H, Hoffmann, C, Franke, G

“…Bioequivalence studies are usually performed as crossover studies and, therefore, information on the intrasubject coefficient of variation is needed for sample…”
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