Search Results - "STEINBACH, Karin"

Resident-Memory T Cells in Tissue-Restricted Immune Responses: For Better or Worse? by Steinbach, Karin, Vincenti, Ilena, Merkler, Doron

“…Tissue-resident-memory CD8+ T cells (T ) have been described as a non-circulating memory T cell subset that persists at sites of previous infection. While T in…”
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Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke by GELDERBLOM, Mathias, LEYPOLDT, Frank, MAGNUS, Tim, STEINBACH, Karin, BEHRENS, Doerthe, CHOE, Chi-Un, SILER, Dominic A, ARUMUGAM, Thiruma V, ORTHEY, Ellen, GERLOFF, Christian, TOLOSA, Eva

“…Ischemic stroke leads to significant morbidity and mortality in the Western world. Early reperfusion strategies remain the treatment of choice but can initiate…”
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Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke by Gelderblom, Mathias, Weymar, Anna, Bernreuther, Christian, Velden, Joachim, Arunachalam, Priyadharshini, Steinbach, Karin, Orthey, Ellen, Arumugam, Thiruma V., Leypoldt, Frank, Simova, Olga, Thom, Vivien, Friese, Manuel A., Prinz, Immo, Hölscher, Christoph, Glatzel, Markus, Korn, Thomas, Gerloff, Christian, Tolosa, Eva, Magnus, Tim

“…The devastating effect of ischemic stroke is attenuated in mice lacking conventional and unconventional T cells, suggesting that inflammation enhances tissue…”
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Neutrophils amplify autoimmune central nervous system infiltrates by maturing local APCs by Steinbach, Karin, Piedavent, Melanie, Bauer, Simone, Neumann, Johannes T, Friese, Manuel A

“…Multiple sclerosis is considered to be initiated by a deregulated, myelin-specific T cell response. However, the formation of inflammatory CNS lesions and the…”
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Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8+ T Cell Responses by Loi, Monica, Müller, Anne, Steinbach, Karin, Niven, Jennifer, Barreira da Silva, Rosa, Paul, Petra, Ligeon, Laure-Anne, Caruso, Assunta, Albrecht, Randy A., Becker, Andrea C., Annaheim, Nicolas, Nowag, Heike, Dengjel, Jörn, García-Sastre, Adolfo, Merkler, Doron, Münz, Christian, Gannagé, Monique

“…The macroautophagy machinery has been implicated in MHC class II restricted antigen presentation. Here, we report that this machinery assists in the…”
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Comparative multi-tissue profiling reveals extensive tissue-specificity in transcriptome reprogramming during thermal adaptation by Hadadi, Noushin, Spiljar, Martina, Steinbach, Karin, Çolakoğlu, Melis, Chevalier, Claire, Salinas, Gabriela, Merkler, Doron, Trajkovski, Mirko

“…Thermal adaptation is an extensively used intervention for enhancing or suppressing thermogenic and mitochondrial activity in adipose tissues. As such, it has…”
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Phenotypical Characterization of Human Th17 Cells Unambiguously Identified by Surface IL-17A Expression by Brucklacher-Waldert, Verena, Steinbach, Karin, Lioznov, Michael, Kolster, Manuela, Holscher, Christoph, Tolosa, Eva

“…Th17 cells are involved in the defense against bacteria and fungi and play a prominent role in the pathogenesis of autoimmune diseases, but research on human…”
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Nogo receptor is involved in the adhesion of dendritic cells to myelin by McDonald, Claire L, Steinbach, Karin, Kern, Florian, Schweigreiter, Rüdiger, Martin, Roland, Bandtlow, Christine E, Reindl, Markus

“…Nogo-66 receptor NgR1 and its structural homologue NgR2 are binding proteins for a number of myelin-associated inhibitory factors. After neuronal injury, these…”
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Nogo-receptors NgR1 and NgR2 do not mediate regulation of CD4 T helper responses and CNS repair in experimental autoimmune encephalomyelitis by Steinbach, Karin, McDonald, Claire L, Reindl, Markus, Schweigreiter, Rüdiger, Bandtlow, Christine, Martin, Roland

“…Myelin-associated inhibition of axonal regrowth after injury is considered one important factor that contributes to regeneration failure in the adult central…”
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Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection by Steinbach, Karin, Vincenti, Ilena, Kreutzfeldt, Mario, Page, Nicolas, Muschaweckh, Andreas, Wagner, Ingrid, Drexler, Ingo, Pinschewer, Daniel, Korn, Thomas, Merkler, Doron

“…Tissue-resident memory T cells (TRM) persist at sites of prior infection and have been shown to enhance pathogen clearance by recruiting circulating immune…”
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Neuropathological Techniques to Investigate CNS Pathology in Experimental Autoimmune Encephalomyelitis (EAE) by Steinbach, Karin, Merkler, Doron

“…Neuropathological techniques such as conventional and immunohistochemical staining of paraffin-embedded tissue sections are instrumental for identification and…”
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Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping by Di Liberto, Giovanni, Pantelyushin, Stanislav, Kreutzfeldt, Mario, Page, Nicolas, Musardo, Stefano, Coras, Roland, Steinbach, Karin, Vincenti, Ilena, Klimek, Bogna, Lingner, Thomas, Salinas, Gabriela, Lin-Marq, Nathalie, Staszewski, Ori, Costa Jordão, Marta Joana, Wagner, Ingrid, Egervari, Kristof, Mack, Matthias, Bellone, Camilla, Blümcke, Ingmar, Prinz, Marco, Pinschewer, Daniel D., Merkler, Doron

“…Inflammatory disorders of the CNS are frequently accompanied by synaptic loss, which is thought to involve phagocytic microglia and complement components…”
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CD8+ MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL‐18 serum levels in multiple sclerosis by Willing, Anne, Leach, Oliver A., Ufer, Friederike, Attfield, Kathrine E., Steinbach, Karin, Kursawe, Nina, Piedavent, Melanie, Friese, Manuel A.

“…Recent findings indicate a pathogenic involvement of IL‐17‐producing CD8+ T cells in multiple sclerosis (MS). IL‐17 production has been attributed to a subset…”
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TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis by Schattling, Benjamin, Steinbach, Karin, Thies, Edda, Kruse, Martin, Menigoz, Aurélie, Ufer, Friederike, Flockerzi, Veit, Brück, Wolfgang, Pongs, Olaf, Vennekens, Rudi, Kneussel, Matthias, Freichel, Marc, Merkler, Doron, Friese, Manuel A

“…Axonal and neuronal damage are commonly seen in patients with multiple sclerosis. Manuel A. Friese and his colleagues now report that the cation channel…”
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Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells by Page, Nicolas, Klimek, Bogna, De Roo, Mathias, Steinbach, Karin, Soldati, Hadrien, Lemeille, Sylvain, Wagner, Ingrid, Kreutzfeldt, Mario, Di Liberto, Giovanni, Vincenti, Ilena, Lingner, Thomas, Salinas, Gabriela, Brück, Wolfgang, Simons, Mikael, Murr, Rabih, Kaye, Jonathan, Zehn, Dietmar, Pinschewer, Daniel D., Merkler, Doron

“…Infections are thought to trigger CD8+ cytotoxic T lymphocyte (CTL) responses during autoimmunity. However, the transcriptional programs governing the…”
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Cold exposure protects from neuroinflammation through immunologic reprogramming by Spiljar, Martina, Steinbach, Karin, Rigo, Dorothée, Suárez-Zamorano, Nicolas, Wagner, Ingrid, Hadadi, Noushin, Vincenti, Ilena, Page, Nicolas, Klimek, Bogna, Rochat, Mary-Aude, Kreutzfeldt, Mario, Chevalier, Claire, Stojanović, Ozren, Bejuy, Olivia, Colin, Didier, Mack, Matthias, Cansever, Dilay, Greter, Melanie, Merkler, Doron, Trajkovski, Mirko

“…Autoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immune-mediated diseases is unclear. Ly6Chi monocytes are…”
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Tissue-resident memory CD8 + T cells cooperate with CD4 + T cells to drive compartmentalized immunopathology in the CNS by Vincenti, Ilena, Page, Nicolas, Steinbach, Karin, Yermanos, Alexander, Lemeille, Sylvain, Nunez, Nicolas, Kreutzfeldt, Mario, Klimek, Bogna, Di Liberto, Giovanni, Egervari, Kristof, Piccinno, Margot, Shammas, Ghazal, Mariotte, Alexandre, Fonta, Nicolas, Liaudet, Nicolas, Shlesinger, Danielle, Liuzzi, Anna Rita, Wagner, Ingrid, Saadi, Cynthia, Stadelmann, Christine, Reddy, Sai, Becher, Burkhard, Merkler, Doron

“…In chronic inflammatory diseases of the central nervous system (CNS), immune cells persisting behind the blood-brain barrier are supposed to promulgate local…”
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Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss by Kreutzfeldt, Mario, Bergthaler, Andreas, Fernandez, Marylise, Brück, Wolfgang, Steinbach, Karin, Vorm, Mariann, Coras, Roland, Blümcke, Ingmar, Bonilla, Weldy V, Fleige, Anne, Forman, Ruth, Müller, Werner, Becher, Burkhard, Misgeld, Thomas, Kerschensteiner, Martin, Pinschewer, Daniel D, Merkler, Doron

“…Neurons are postmitotic and thus irreplaceable cells of the central nervous system (CNS). Accordingly, CNS inflammation with resulting neuronal damage can have…”
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Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function by Piédavent-Salomon, Melanie, Willing, Anne, Engler, Jan Broder, Steinbach, Karin, Bauer, Simone, Eggert, Britta, Ufer, Friederike, Kursawe, Nina, Wehrmann, Sabine, Jäger, Jan, Reinhardt, Stefanie, Friese, Manuel A

“…Recent association studies have linked numerous genetic variants with an increased risk for multiple sclerosis, although their functional relevance remains…”
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Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis by Abramowski, Pierre, Steinbach, Karin, Zander, Axel R, Martin, Roland

“…Abstract The 2-lysophosphatidylcholine analog edelfosine induces apoptosis in highly proliferating cells, e.g. activated immune cells. We examined mechanisms…”
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