Search Results - "STEIN, ROLAND"

Microtubules Negatively Regulate Insulin Secretion in Pancreatic β Cells by Zhu, Xiaodong, Hu, Ruiying, Brissova, Marcela, Stein, Roland W., Powers, Alvin C., Gu, Guoqiang, Kaverina, Irina

“…For glucose-stimulated insulin secretion (GSIS), insulin granules have to be localized close to the plasma membrane. The role of microtubule-dependent…”
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Evidence for Loss in Identity, De-Differentiation, and Trans -Differentiation of Islet β-Cells in Type 2 Diabetes by Hunter, Chad S, Stein, Roland W

“…The two main types of diabetes mellitus have distinct etiologies, yet a similar outcome: loss of islet β-cell function that is solely responsible for the…”
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Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells by Banerjee, Ronadip R, Cyphert, Holly A, Walker, Emily M, Chakravarthy, Harini, Peiris, Heshan, Gu, Xueying, Liu, Yinghua, Conrad, Elizabeth, Goodrich, Lisa, Stein, Roland W, Kim, Seung K

“…β-Cell proliferation and expansion during pregnancy are crucial for maintaining euglycemia in response to increased metabolic demands placed on the mother…”
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Metabolic stress levels influence the ability of the myelin transcription factors to regulate β-cell identity and survival by Tong, Xin, Yagan, Mahircan, Hu, Ruiying, Nevills, Simone, Stevenson, Teri D, Stein, Roland W, Balamurugan, Appakalai N, Gu, Guoqiang

“…A hallmark of type 2 diabetes (T2D) is endocrine islet β-cell failure, which can occur via cell dysfunction, loss-of-identity, and/or death. How each is…”
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Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health by Tong, Xin, Dai, Chunhua, Walker, John T, Nair, Gopika G, Kennedy, Arion, Carr, Rotonya M, Hebrok, Matthias, Powers, Alvin C, Stein, Roland

“…Human but not mouse islets transplanted into immunodeficient NSG mice effectively accumulate lipid droplets (LDs). Because chronic lipid exposure is associated…”
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Loss of the transcription factor MAFB limits β-cell derivation from human PSCs by Russell, Ronan, Carnese, Phichitpol P., Hennings, Thomas G., Walker, Emily M., Russ, Holger A., Liu, Jennifer S., Giacometti, Simone, Stein, Roland, Hebrok, Matthias

“…Next generation sequencing studies have highlighted discrepancies in β-cells which exist between mice and men. Numerous reports have identified MAF BZIP…”
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Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks by Haliyur, Rachana, Tong, Xin, Sanyoura, May, Shrestha, Shristi, Lindner, Jill, Saunders, Diane C, Aramandla, Radhika, Poffenberger, Greg, Redick, Sambra D, Bottino, Rita, Prasad, Nripesh, Levy, Shawn E, Blind, Raymond D, Harlan, David M, Philipson, Louis H, Stein, Roland W, Brissova, Marcela, Powers, Alvin C

“…Using an integrated approach to characterize the pancreatic tissue and isolated islets from a 33-year-old with 17 years of type 1 diabetes (T1D), we found that…”
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α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes by Brissova, Marcela, Haliyur, Rachana, Saunders, Diane, Shrestha, Shristi, Dai, Chunhua, Blodgett, David M., Bottino, Rita, Campbell-Thompson, Martha, Aramandla, Radhika, Poffenberger, Gregory, Lindner, Jill, Pan, Fong Cheng, von Herrath, Matthias G., Greiner, Dale L., Shultz, Leonard D., Sanyoura, May, Philipson, Louis H., Atkinson, Mark, Harlan, David M., Levy, Shawn E., Prasad, Nripesh, Stein, Roland, Powers, Alvin C.

“…Many patients with type 1 diabetes (T1D) have residual β cells producing small amounts of C-peptide long after disease onset but develop an inadequate glucagon…”
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Dynamic Recruitment of Functionally Distinct Swi/Snf Chromatin Remodeling Complexes Modulates Pdx1 Activity in Islet β Cells by McKenna, Brian, Guo, Min, Reynolds, Albert, Hara, Manami, Stein, Roland

“…Pdx1 is a transcription factor of fundamental importance to pancreas formation and adult islet β cell function. However, little is known about the positive-…”
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Repression of latent NF-κB enhancers by PDX1 regulates β cell functional heterogeneity by Weidemann, Benjamin J, Marcheva, Biliana, Kobayashi, Mikoto, Omura, Chiaki, Newman, Marsha V, Kobayashi, Yumiko, Waldeck, Nathan J, Perelis, Mark, Lantier, Louise, McGuinness, Owen P, Ramsey, Kathryn Moynihan, Stein, Roland W, Bass, Joseph

“…Interactions between lineage-determining and activity-dependent transcription factors determine single-cell identity and function within multicellular tissues…”
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Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state by Dai, Xiao-Qing, Camunas-Soler, Joan, Briant, Linford J B, Dos Santos, Theodore, Spigelman, Aliya F, Walker, Emily M, Arrojo E Drigo, Rafael, Bautista, Austin, Jones, Robert C, Avrahami, Dana, Lyon, James, Nie, Aifang, Smith, Nancy, Zhang, Yongneng, Johnson, Janyne, Manning Fox, Jocelyn E, Michelakis, Evangelos D, Light, Peter E, Kaestner, Klaus H, Kim, Seung K, Rorsman, Patrik, Stein, Roland W, Quake, Stephen R, MacDonald, Patrick E

“…In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying mechanisms, and whether dysfunction occurs uniformly among cells,…”
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Imaging mass spectrometry enables molecular profiling of mouse and human pancreatic tissue by Prentice, Boone M., Hart, Nathaniel J., Phillips, Neil, Haliyur, Rachana, Judd, Audra, Armandala, Radhika, Spraggins, Jeffrey M., Lowe, Cindy L., Boyd, Kelli L., Stein, Roland W., Wright, Christopher V., Norris, Jeremy L., Powers, Alvin C., Brissova, Marcela, Caprioli, Richard M.

“…Aims/hypothesis The molecular response and function of pancreatic islet cells during metabolic stress is a complex process. The anatomical location and small…”
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Stress-impaired transcription factor expression and insulin secretion in transplanted human islets by Dai, Chunhua, Kayton, Nora S, Shostak, Alena, Poffenberger, Greg, Cyphert, Holly A, Aramandla, Radhika, Thompson, Courtney, Papagiannis, Ioannis G, Emfinger, Christopher, Shiota, Masakazu, Stafford, John M, Greiner, Dale L, Herrera, Pedro L, Shultz, Leonard D, Stein, Roland, Powers, Alvin C

“…Type 2 diabetes is characterized by insulin resistance, hyperglycemia, and progressive β cell dysfunction. Excess glucose and lipid impair β cell function in…”
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Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages – a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape by Montalbán del Barrio, Itsaso, Penski, Cornelia, Schlahsa, Laura, Stein, Roland G., Diessner, Joachim, Wöckel, Achim, Dietl, Johannes, Lutz, Manfred B., Mittelbronn, Michel, Wischhusen, Jörg, Häusler, Sebastian F. M.

“…BackgroundOvarian cancer (OvCA) tissues show abundant expression of the ectonucleotidases CD39 and CD73 which generate immunomodulatory adenosine, thereby…”
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Cognate Nonlytic Interactions between CD8 + T Cells and Breast Cancer Cells Induce Cancer Stem Cell-like Properties by Stein, Roland G, Ebert, Stefan, Schlahsa, Laura, Scholz, Claus J, Braun, Matthias, Hauck, Petra, Horn, Evi, Monoranu, Camelia-Maria, Thiemann, Vincent J, Wustrow, Michael P, Häusler, Sebastian F, Montalbán Del Barrio, Itsaso, Stüber, Tanja N, Wölfl, Matthias, Dietl, Johannes, Rosenwald, Andreas, Diessner, Joachim E, Wöckel, Achim, Wischhusen, Jörg

“…Targeting of tumor immune escape mechanisms holds enormous therapeutic potential. Still, most patients progress under immune checkpoint blockade and some even…”
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Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion by Häusler, Sebastian Fm, Del Barrio, Itsaso Montalbán, Diessner, Joachim, Stein, Roland G, Strohschein, Jenny, Hönig, Arnd, Dietl, Johannes, Wischhusen, Jörg

“…The ectonucleotidases CD39 and CD73 degrade ATP to adenosine which inhibits immune responses via the A2A adenosine receptor (ADORA2A) on T and NK cells. The…”
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MafB is required for islet β cell maturation by Artner, Isabella, Blanchi, Bruno, Raum, Jeffrey C, Guo, Min, Kaneko, Tomomi, Cordes, Sabine, Sieweke, Michael, Stein, Roland

“…Pancreatic endocrine cell differentiation depends on transcription factors that also contribute in adult insulin and glucagon gene expression. Islet cell…”
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Islet-1 is Required for the Maturation, Proliferation, and Survival of the Endocrine Pancreas by AIPING DU, HUNTER, Chad S, MURRAY, Johanna, NOBLE, Daniel, CAI, Chen-Leng, EVANS, Sylvia M, STEIN, Roland, MAY, Catherine Lee

“…Islet-1 is Required for the Maturation, Proliferation, and Survival of the Endocrine Pancreas Aiping Du 1 , Chad S. Hunter 2 , Johanna Murray 1 , Daniel Noble…”
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Oxidative Stress-mediated, Post-translational Loss of MafA Protein as a Contributing Mechanism to Loss of Insulin Gene Expression in Glucotoxic Beta Cells by Harmon, Jamie S., Stein, Roland, Robertson, R. Paul

“…Glucose toxicity in pancreatic islet beta cells causes loss of insulin gene expression, content, and secretion due to loss of binding of transcription factors,…”
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In vivo studies of glucagon secretion by human islets transplanted in mice by Tellez, Krissie, Hang, Yan, Gu, Xueying, Chang, Charles A., Stein, Roland W., Kim, Seung K.

“…Little is known about regulated glucagon secretion by human islet α-cells compared to insulin secretion from β-cells, despite conclusive evidence of…”
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