Search Results - "STEIN, Linda"

Tapinarof in the treatment of psoriasis: A review of the unique mechanism of action of a novel therapeutic aryl hydrocarbon receptor–modulating agent by Bissonnette, Robert, Stein Gold, Linda, Rubenstein, David S., Tallman, Anna M., Armstrong, April

“…Tapinarof, a novel, first-in-class, small-molecule topical therapeutic aryl hydrocarbon receptor (AhR)–modulating agent, is in clinical development for the…”
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Two Phase 3 Trials of Lebrikizumab for Moderate-to-Severe Atopic Dermatitis by Silverberg, Jonathan I., Guttman-Yassky, Emma, Thaçi, Diamant, Irvine, Alan D., Stein Gold, Linda, Blauvelt, Andrew, Simpson, Eric L., Chu, Chia-Yu, Liu, Zhuqing, Gontijo Lima, Renata, Pillai, Sreekumar G., Seneschal, Julien

“…In the induction period of two phase 3 trials, 16 weeks of treatment with lebrikizumab was effective in adolescents and adults with moderate-to-severe atopic…”
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Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults by Paller, Amy S., MS, MD, Tom, Wynnis L., MD, Lebwohl, Mark G., MD, Blumenthal, Robin L., PhD, Boguniewicz, Mark, MD, Call, Robert S., MD, Eichenfield, Lawrence F., MD, Forsha, Douglass W., MD, Rees, William C., MD, Simpson, Eric L., MD, Spellman, Mary C., MD, Stein Gold, Linda F., MD, Zaenglein, Andrea L., MD, Hughes, Matilda H., CCRA, Zane, Lee T., MD, Hebert, Adelaide A., MD

“…Background Additional topical treatments for atopic dermatitis (AD) are needed that provide relief while minimizing risks. Objective We sought to assess the…”
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Efficacy and Safety of Upadacitinib in Patients With Moderate to Severe Atopic Dermatitis: Analysis of Follow-up Data From the Measure Up 1 and Measure Up 2 Randomized Clinical Trials by Simpson, Eric L, Papp, Kim A, Blauvelt, Andrew, Chu, Chia-Yu, Hong, H Chih-Ho, Katoh, Norito, Calimlim, Brian M, Thyssen, Jacob P, Chiou, Albert S, Bissonnette, Robert, Stein Gold, Linda F, Wegzyn, Colleen, Hu, Xiaofei, Liu, Meng, Liu, John, Tenorio, Allan R, Chu, Alvina D, Guttman-Yassky, Emma

“…Primary results from the Measure Up 1 and Measure Up 2 studies demonstrated upadacitinib efficacy and safety through 16 weeks in patients with atopic…”
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Guidelines of care for the management of acne vulgaris by Zaenglein, Andrea L., MD, Pathy, Arun L., MD, Schlosser, Bethanee J., MD, PhD, Alikhan, Ali, MD, Baldwin, Hilary E., MD, Berson, Diane S., MD, Bowe, Whitney P., MD, Graber, Emmy M., MD, Harper, Julie C., MD, Kang, Sewon, MD, Keri, Jonette E., MD, PhD, Leyden, James J., MD, Reynolds, Rachel V., MD, Silverberg, Nanette B., MD, Stein Gold, Linda F., MD, Tollefson, Megha M., MD, Weiss, Jonathan S., MD, Dolan, Nancy C., MD, Sagan, Andrew A., MD, Stern, Mackenzie, Boyer, Kevin M., MPH, Bhushan, Reva, MA, PhD

“…Acne is one of the most common disorders treated by dermatologists and other health care providers. While it most often affects adolescents, it is not uncommon…”
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Phase 3 Trials of Tapinarof Cream for Plaque Psoriasis by Lebwohl, Mark G, Stein Gold, Linda, Strober, Bruce, Papp, Kim A, Armstrong, April W, Bagel, Jerry, Kircik, Leon, Ehst, Benjamin, Hong, H. Chih-ho, Soung, Jennifer, Fromowitz, Jeff, Guenthner, Scott, Piscitelli, Stephen C, Rubenstein, David S, Brown, Philip M, Tallman, Anna M, Bissonnette, Robert

“…In two identical trials of treatment for psoriasis with the topical aryl hydrocarbon receptor–modulating agent tapinarof, clearance or near-clearance of…”
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A phase 2b, randomized clinical trial of tapinarof cream for the treatment of plaque psoriasis: Secondary efficacy and patient-reported outcomes by Stein Gold, Linda, Bhatia, Neal, Tallman, Anna M., Rubenstein, David S.

“…Tapinarof cream is a topical therapeutic aryl hydrocarbon receptor modulating agent under investigation for treatment of psoriasis and atopic dermatitis. In a…”
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One-year safety and efficacy of tapinarof cream for the treatment of plaque psoriasis: Results from the PSOARING 3 trial by Strober, Bruce, Stein Gold, Linda, Bissonnette, Robert, Armstrong, April W., Kircik, Leon, Tyring, Stephen K., Piscitelli, Stephen C., Brown, Philip M., Rubenstein, David S., Tallman, Anna M., Lebwohl, Mark G.

“…Tapinarof cream 1% once daily, an aryl hydrocarbon receptor-modulating agent, was significantly more efficacious than vehicle and well tolerated in two 12-week…”
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Trial of Roflumilast Cream for Chronic Plaque Psoriasis by Lebwohl, Mark G, Papp, Kim A, Stein Gold, Linda, Gooderham, Melinda J, Kircik, Leon H, Draelos, Zoe D, Kempers, Steven E, Zirwas, Mathew, Smith, Kathleen, Osborne, David W, Trotman, Marie-Louise, Navale, Lynn, Merritt, Charlotte, Berk, David R, Welgus, Howard

“…A cream formulation of the phosphodiesterase type 4 inhibitor roflumilast, in two concentrations, led to higher percentages of patients with clearance or…”
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Long-term safety of crisaborole ointment 2% in children and adults with mild to moderate atopic dermatitis by Eichenfield, Lawrence F., Call, Robert S., Forsha, Douglass W., Fowler, Joseph, Hebert, Adelaide A., Spellman, Mary, Stein Gold, Linda F., Van Syoc, Merrie, Zane, Lee T., Tschen, Eduardo

“…Long-term topical treatment is often required for atopic dermatitis (AD), a chronic inflammatory skin disease. To assess the long-term safety results from a…”
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Guidelines of care for the management of acne vulgaris by Reynolds, Rachel V., Yeung, Howa, Cheng, Carol E., Cook-Bolden, Fran, Desai, Seemal R., Druby, Kelly M., Freeman, Esther E., Keri, Jonette E., Stein Gold, Linda F., Tan, Jerry K.L., Tollefson, Megha M., Weiss, Jonathan S., Wu, Peggy A., Zaenglein, Andrea L., Han, Jung Min, Barbieri, John S.

“…Acne vulgaris commonly affects adults, adolescents, and preadolescents aged 9 years or older. The objective of this study was to provide evidence-based…”
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OPA-15406, a novel, topical, nonsteroidal, selective phosphodiesterase-4 (PDE4) inhibitor, in the treatment of adult and adolescent patients with mild to moderate atopic dermatitis (AD): A phase-II randomized, double-blind, placebo-controlled study by Hanifin, Jon M., MD, Ellis, Charles N., MD, Frieden, Ilona J., MD, Fölster-Holst, Regina, MD, Stein Gold, Linda F., MD, Secci, Angelo, MD, Smith, Angela J., PA, Zhao, Cathy, PhD, Kornyeyeva, Elena, MD, PhD, Eichenfield, Lawrence F., MD

“…Background Peripheral leukocytes in patients with atopic dermatitis (AD) have elevated phosphodiesterase-4 activity, which is associated with production of…”
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Nemolizumab with concomitant topical therapy in adolescents and adults with moderate-to-severe atopic dermatitis (ARCADIA 1 and ARCADIA 2): results from two replicate, double-blind, randomised controlled phase 3 trials by Silverberg, Jonathan I, Wollenberg, Andreas, Reich, Adam, Thaçi, Diamant, Legat, Franz J, Papp, Kim A, Stein Gold, Linda, Bouaziz, Jean-David, Pink, Andrew E, Carrascosa, José Manuel, Rewerska, Barbara, Szepietowski, Jacek C, Krasowska, Dorota, Havlíčková, Blanka, Kalowska, Monika, Magnolo, Nina, Pauser, Sylvia, Nami, Navid, Sauder, Maxwell B, Jain, Vipul, Padlewska, Kamila, Cheong, Soo Yeon, Fleuranceau Morel, Patricia, Ulianov, Liliana, Piketty, Christophe

“…Nemolizumab, an interleukin (IL)-31 receptor subunit α antagonist, inhibits the IL-31 pathway of itch and skin inflammation in atopic dermatitis. Two…”
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Efficacy and Safety of Topical Clascoterone Cream, 1%, for Treatment in Patients With Facial Acne: Two Phase 3 Randomized Clinical Trials by Hebert, Adelaide, Thiboutot, Diane, Stein Gold, Linda, Cartwright, Martina, Gerloni, Mara, Fragasso, Enrico, Mazzetti, Alessandro

“…Acne is a common, multifactorial skin condition, and treatments with novel mechanisms have been elusive. To assess the safety and efficacy of clascoterone…”
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Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies by Stein, Linda, Kircik, Leon, Fowler, Joseph, Tan, Jerry, Draelos, Zoe, Fleischer, Alan, Appell, Melanie, Steinhoff, Martin, Lynde, Charles, Liu, Hong, Jacovella, Jean

“…Treatments for papulopustular rosacea (PPR) are limited. To demonstrate the efficacy and safety of once-daily ivermectin 1% cream in subjects with moderate to…”
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The importance of early diagnosis and treatment of actinic keratosis by Rigel, Darrell S., MD, Stein Gold, Linda F., MD

“…Chronic, long-term sun exposure results in genetic changes in epidermal keratinocytes and the development of various skin lesions ranging from actinic…”
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Efficacy and Safety of Crisaborole Ointment, 2%, for the Treatment of Mild-to-Moderate Atopic Dermatitis Across Racial and Ethnic Groups by Callender, Valerie D., Alexis, Andrew F., Stein Gold, Linda F., Lebwohl, Mark G., Paller, Amy S., Desai, Seemal R., Tan, Huaming, Ports, William C., Zielinski, Michael A., Tallman, Anna M.

“…Background Atopic dermatitis is highly prevalent in black/African American, Asian, and Hispanic patients, making assessment of these populations in clinical…”
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Importance of treating acne sequelae in skin of color: 6‐month phase IV study of trifarotene with an appropriate skincare routine including UV protection in acne‐induced post‐inflammatory hyperpigmentation by Alexis, Andrew, Del Rosso, James Q., Forman, Seth, Martorell, Antonio, Browning, John, Laquer, Vivian, Desai, Seemal R., York, Jean Philippe, Chavda, Rajeev, Dhawan, Sunil, Moore, Angela Y., Stein‐Gold, Linda

“…Background Acne‐induced hyperpigmentation (AIH) may accompany acne vulgaris (AV) inflammation in all skin phototypes. Trifarotene has shown depigmenting…”
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Efficacy and patient-reported outcomes from a phase 2b, randomized clinical trial of tapinarof cream for the treatment of adolescents and adults with atopic dermatitis by Paller, Amy S., Stein Gold, Linda, Soung, Jennifer, Tallman, Anna M., Rubenstein, David S., Gooderham, Melinda

“…Tapinarof is a topical therapeutic aryl hydrocarbon receptor modulating agent under investigation for atopic dermatitis (AD) and psoriasis treatment. A phase…”
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The Importance of Assessing Burning and Stinging when Managing Rosacea: A Review by Schaller, Martin, Dirschka, Thomas, Lonne-Rahm, Sol-Britt, Micali, Giuseppe, Stein Gold, Linda F., Tan, Jerry, Del Rosso, James

“…Rosacea, a chronic condition usually recognized by its visible presentation, can be accompanied by invisible symptoms, such as burning and stinging. The aim of…”
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