Search Results - "STEIN, Janet L"

MicroRNA control of bone formation and homeostasis by Lian, Jane B., Stein, Gary S., van Wijnen, Andre J., Stein, Janet L., Hassan, Mohammad Q., Gaur, Tripti, Zhang, Ying

“…MicroRNAs (miRNAs) have emerged as key regulators of bone development, remodeling and pathologies. This Review discusses the critical functions of miRNAs…”
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Targeting of Runx2 by miR-135 and miR-203 Impairs Progression of Breast Cancer and Metastatic Bone Disease by Taipaleenmäki, Hanna, Browne, Gillian, Akech, Jacqueline, Zustin, Jozef, van Wijnen, Andre J, Stein, Janet L, Hesse, Eric, Stein, Gary S, Lian, Jane B

“…Progression of breast cancer to metastatic bone disease is linked to deregulated expression of the transcription factor Runx2. Therefore, our goal was to…”
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program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2 by Zhang, Ying, Xie, Rong-lin, Croce, Carlo M, Stein, Janet L, Lian, Jane B, van Wijnen, Andre J, Stein, Gary S

“…Lineage progression in osteoblasts and chondrocytes is stringently controlled by the cell-fate-determining transcription factor Runx2. In this study, we…”
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Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells by Barutcu, A Rasim, Lajoie, Bryan R, McCord, Rachel P, Tye, Coralee E, Hong, Deli, Messier, Terri L, Browne, Gillian, van Wijnen, Andre J, Lian, Jane B, Stein, Janet L, Dekker, Job, Imbalzano, Anthony N, Stein, Gary S

“…Higher-order chromatin structure is often perturbed in cancer and other pathological states. Although several genetic and epigenetic differences have been…”
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Classification of natural flow regimes in Australia to support environmental flow management by KENNARD, MARK J., PUSEY, BRADLEY J., OLDEN, JULIAN D., MACKAY, STEPHEN J., STEIN, JANET L., MARSH, NICK

“…Summary 1. The importance of hydrologic variability for shaping the biophysical attributes and functioning of riverine ecosystems is well recognised by…”
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miR-218 Directs a Wnt Signaling Circuit to Promote Differentiation of Osteoblasts and Osteomimicry of Metastatic Cancer Cells by Hassan, Mohammad Q., Maeda, Yukiko, Taipaleenmaki, Hanna, Zhang, Weibing, Jafferji, Mohammad, Gordon, Jonathan A.R., Li, Zhaoyong, Croce, Carlo M., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.

“…MicroRNAs (miRNAs) negatively and post-transcriptionally regulate expression of multiple target genes to support anabolic pathways for bone formation. Here, we…”
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microRNA signature for a BMP2-induced osteoblast lineage commitment program by Li, Zhaoyong, Hassan, Mohammad Q, Volinia, Stefano, van Wijnen, Andre J, Stein, Janet L, Croce, Carlo M, Lian, Jane B, Stein, Gary S

“…Bone morphogenetic proteins (BMPs) are potent morphogens that activate transcriptional programs for lineage determination. How BMP induction of a phenotype is…”
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Biological Functions of miR-29b Contribute to Positive Regulation of Osteoblast Differentiation by Li, Zhaoyong, Hassan, Mohammad Q., Jafferji, Mohammed, Aqeilan, Rami I., Garzon, Ramiro, Croce, Carlo M., van Wijnen, Andre J., Stein, Janet L., Stein, Gary S., Lian, Jane B.

“…Bone tissue arises from mesenchymal cells induced into the osteoblast lineage by essential transcription factors and signaling cascades. MicroRNAs regulate…”
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Identification of molecularly unique tumor-associated mesenchymal stromal cells in breast cancer patients by Gordon, Jonathan A R, Evans, Mark F, Ghule, Prachi N, Lee, Kyra, Vacek, Pamela, Sprague, Brian L, Weaver, Donald L, Stein, Gary S, Stein, Janet L

“…The tumor microenvironment is a complex mixture of cell types that bi-directionally interact and influence tumor initiation, progression, recurrence, and…”
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RUNX1 and RUNX2 transcription factors function in opposing roles to regulate breast cancer stem cells by Fritz, Andrew J., Hong, Deli, Boyd, Joseph, Kost, Jason, Finstaad, Kristiaan H., Fitzgerald, Mark P., Hanna, Sebastian, Abuarqoub, Alqassem H., Malik, Miles, Bushweller, John, Tye, Coralee, Ghule, Prachi, Gordon, Jonathan, Frietze, Seth, Zaidi, Sayyed K., Lian, Jane B., Stein, Janet L., Stein, Gary S.

“…Breast cancer stem cells (BCSCs) are competent to initiate tumor formation and growth and refractory to conventional therapies. Consequently BCSCs are…”
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network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program by Hassan, Mohammad Q, Gordon, Jonathan A.R, Beloti, Marcio M, Croce, Carlo M, Wijnen, Andre J. van, Stein, Janet L, Stein, Gary S, Lian, Jane B

“…Induced osteogenesis includes a program of microRNAs (miRs) to repress the translation of genes that act as inhibitors of bone formation. How expression of…”
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Suppression of Breast Cancer Stem Cells and Tumor Growth by the RUNX1 Transcription Factor by Hong, Deli, Fritz, Andrew J, Finstad, Kristiaan H, Fitzgerald, Mark P, Weinheimer, Adam, Viens, Adam L, Ramsey, Jon, Stein, Janet L, Lian, Jane B, Stein, Gary S

“…Breast cancer remains the most common malignant disease in women worldwide. Despite advances in detection and therapies, studies are still needed to understand…”
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Mitotically-Associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer by Tracy, Kirsten M, Tye, Coralee E, Ghule, Prachi N, Malaby, Heidi L H, Stumpff, Jason, Stein, Janet L, Stein, Gary S, Lian, Jane B

“…Aggressive breast cancer is difficult to treat as it is unresponsive to many hormone-based therapies; therefore, it is imperative to identify novel, targetable…”
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Ecosystem accounts define explicit and spatial trade-offs for managing natural resources by Keith, Heather, Vardon, Michael, Stein, John A., Stein, Janet L., Lindenmayer, David

“…Decisions about natural resource management are frequently complex and vexed, often leading to public policy compromises. Discord between environmental and…”
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RUNX1‐dependent mechanisms in biological control and dysregulation in cancer by Hong, Deli, Fritz, Andrew J., Gordon, Jonathan A., Tye, Coralee E., Boyd, Joseph R., Tracy, Kirsten M., Frietze, Seth E., Carr, Frances E., Nickerson, Jeffrey A., Wijnen, Andre J., Imbalzano, Anthony N., Zaidi, Sayyed K., Lian, Jane B., Stein, Janet L., Stein, Gary S.

“…The RUNX1 transcription factor has recently been shown to be obligatory for normal development. RUNX1 controls the expression of genes essential for proper…”
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Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B by Rojas, Adriana, Aguilar, Rodrigo, Henriquez, Berta, Lian, Jane B., Stein, Janet L., Stein, Gary S., van Wijnen, Andre J., van Zundert, Brigitte, Allende, Miguel L., Montecino, Martin

“…Transcription factor Runx2 controls bone development and osteoblast differentiation by regulating expression of a significant number of bone-related target…”
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SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells by Barutcu, A Rasim, Lajoie, Bryan R, Fritz, Andrew J, McCord, Rachel P, Nickerson, Jeffrey A, van Wijnen, Andre J, Lian, Jane B, Stein, Janet L, Dekker, Job, Stein, Gary S, Imbalzano, Anthony N

“…The packaging of DNA into chromatin plays an important role in transcriptional regulation and nuclear processes. Brahma-related gene-1 SMARCA4 (also known as…”
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The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer by Wu, Qiong, Lian, Jane B, Stein, Janet L, Stein, Gary S, Nickerson, Jeffrey A, Imbalzano, Anthony N

“…Mammalian SWI/SNF enzymes are ATP-dependent remodelers of chromatin structure. These multisubunit enzymes are heterogeneous in composition; there are two…”
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MicroRNAs in the control of metastatic bone disease by Browne, Gillian, Taipaleenmäki, Hanna, Stein, Gary S, Stein, Janet L, Lian, Jane B

“…Highlights • Metastatic bone disease occurs due to complex interactions between cancer cells and the bone microenvironment. • miRNAs important for bone…”
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MicroRNAs 221 and 222 bypass quiescence and compromise cell survival by Medina, Ricardo, Zaidi, Sayyed K, Liu, Chang-Gong, Stein, Janet L, van Wijnen, Andre J, Croce, Carlo M, Stein, Gary S

“…MicroRNAs (miRNA) have tumor suppressive and oncogenic potential in human cancer, but whether and how miRNAs control cell cycle progression is not understood…”
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