Search Results - "STEIN, C. Michael"

Azithromycin and the Risk of Cardiovascular Death by Ray, Wayne A, Murray, Katherine T, Hall, Kathi, Arbogast, Patrick G, Stein, C. Michael

“…In a large cohort study, patients who took azithromycin had significantly increased risks of cardiovascular death and death from any cause during a 5-day…”
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Prescription of Long-Acting Opioids and Mortality in Patients With Chronic Noncancer Pain by Ray, Wayne A, Chung, Cecilia P, Murray, Katherine T, Hall, Kathi, Stein, C. Michael

“…IMPORTANCE: Long-acting opioids increase the risk of unintentional overdose deaths but also may increase mortality from cardiorespiratory and other causes…”
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Antipsychotics and the risk of type 2 diabetes mellitus in children and youth by Bobo, William V, Cooper, William O, Stein, C Michael, Olfson, Mark, Graham, David, Daugherty, James, Fuchs, D Catherine, Ray, Wayne A

“…The increased prescribing of antipsychotics for children and youth has heightened concerns that this practice increases the risk of type 2 diabetes mellitus…”
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Atypical Antipsychotic Drugs and the Risk of Sudden Cardiac Death by Ray, Wayne A, Chung, Cecilia P, Murray, Katherine T, Hall, Kathi, Stein, C. Michael

“…It is known that the use of typical antipsychotic agents (e.g., haloperidol) is associated with an increased risk of sudden cardiac death. This study shows…”
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Opioid Analgesic Use and Risk for Invasive Pneumococcal Diseases: A Nested Case-Control Study by Wiese, Andrew D, Griffin, Marie R, Schaffner, William, Stein, C Michael, Greevy, Robert A, Mitchel, Jr, Edward F, Grijalva, Carlos G

“…Although certain opioid analgesics have immunosuppressive properties and increase the risk for infections in animals, the clinical effects of prescription…”
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ADHD Drugs and Serious Cardiovascular Events in Children and Young Adults by Cooper, William O, Habel, Laurel A, Sox, Colin M, Chan, K. Arnold, Arbogast, Patrick G, Cheetham, T. Craig, Murray, Katherine T, Quinn, Virginia P, Stein, C. Michael, Callahan, S. Todd, Fireman, Bruce H, Fish, Frank A, Kirshner, Howard S, O'Duffy, Anne, Connell, Frederick A, Ray, Wayne A

“…This large study found no increased risk of cardiovascular events in children and young adults using attention deficit–hyperactivity disorder (ADHD) drugs…”
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Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension by Wu, Patrick, Feng, QiPing, Kerchberger, Vern Eric, Nelson, Scott D., Chen, Qingxia, Li, Bingshan, Edwards, Todd L., Cox, Nancy J., Phillips, Elizabeth J., Stein, C. Michael, Roden, Dan M., Denny, Joshua C., Wei, Wei-Qi

“…Discovering novel uses for existing drugs, through drug repurposing, can reduce the time, costs, and risk of failure associated with new drug development…”
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Role of inflammation and oxidative stress in atrial fibrillation by Li, Jie, MD, Solus, Joseph, PhD, Chen, Qingxia, PhD, Rho, Young Hee, MD, PhD, Milne, Ginger, PhD, Stein, C. Michael, MD, Darbar, Dawood, MD

“…Background Atrial fibrillation (AF) is the most common arrhythmia seen in clinical practice. Increasing evidence indicates that inflammation and oxidative…”
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Mortality and concurrent use of opioids and hypnotics in older patients: A retrospective cohort study by Ray, Wayne A, Chung, Cecilia P, Murray, Katherine T, Malow, Beth A, Daugherty, James R, Stein, C. Michael

“…Background Benzodiazepine hypnotics and the related nonbenzodiazepine hypnotics (z-drugs) are among the most frequently prescribed medications for older…”
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Predictive Utility of Polygenic Risk Scores for Coronary Heart Disease in Three Major Racial and Ethnic Groups by Dikilitas, Ozan, Schaid, Daniel J., Kosel, Matthew L., Carroll, Robert J., Chute, Christopher G., Denny, Joshua C., Fedotov, Alex, Feng, QiPing, Hakonarson, Hakon, Jarvik, Gail P., Lee, Ming Ta Michael, Pacheco, Jennifer A., Rowley, Robb, Sleiman, Patrick M., Stein, C. Michael, Sturm, Amy C., Wei, Wei-Qi, Wiesner, Georgia L., Williams, Marc S., Zhang, Yanfei, Manolio, Teri A., Kullo, Iftikhar J.

“…Because polygenic risk scores (PRSs) for coronary heart disease (CHD) are derived from mainly European ancestry (EA) cohorts, their validity in African…”
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PheMap: a multi-resource knowledge base for high-throughput phenotyping within electronic health records by Zheng, Neil S, Feng, QiPing, Kerchberger, V Eric, Zhao, Juan, Edwards, Todd L, Cox, Nancy J, Stein, C Michael, Roden, Dan M, Denny, Joshua C, Wei, Wei-Qi

“…Abstract Objective Developing algorithms to extract phenotypes from electronic health records (EHRs) can be challenging and time-consuming. We developed…”
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An automated database case definition for serious bleeding related to oral anticoagulant use by Cunningham, Andrew, Stein, C. Michael, Chung, Cecilia P., Daugherty, James R., Smalley, Walter E., Ray, Wayne A.

“…ABSTRACT Purpose Bleeding complications are a serious adverse effect of medications that prevent abnormal blood clotting. To facilitate epidemiologic…”
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LPA Variants Are Associated With Residual Cardiovascular Risk in Patients Receiving Statins by Wei, Wei-Qi, Li, Xiaohui, Feng, Qiping, Kubo, Michiaki, Kullo, Iftikhar J, Peissig, Peggy L, Karlson, Elizabeth W, Jarvik, Gail P, Lee, Ming Ta Michael, Shang, Ning, Larson, Eric A, Edwards, Todd, Shaffer, Christian M, Mosley, Jonathan D, Maeda, Shiro, Horikoshi, Momoko, Ritchie, Marylyn, Williams, Marc S, Larson, Eric B, Crosslin, David R, Bland, Sarah T, Pacheco, Jennifer A, Rasmussen-Torvik, Laura J, Cronkite, David, Hripcsak, George, Cox, Nancy J, Wilke, Russell A, Stein, C Michael, Rotter, Jerome I, Momozawa, Yukihide, Roden, Dan M, Krauss, Ronald M, Denny, Joshua C

“…BACKGROUND:Coronary heart disease (CHD) is a leading cause of death globally. Although therapy with statins decreases circulating levels of low-density…”
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Genetic Determinants of Response to Warfarin during Initial Anticoagulation by Schwarz, Ute I, Ritchie, Marylyn D, Bradford, Yuki, Li, Chun, Dudek, Scott M, Frye-Anderson, Amy, Kim, Richard B, Roden, Dan M, Stein, C. Michael

“…Variants of the genes CYP2C9 and VKORC1 contribute to differences in the anticoagulant effect of warfarin among patients. The relative roles of these variants…”
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Genetic susceptibility for autoimmune diseases and white blood cell count by Vaitinadin, Nataraja Sarma, Stein, C. Michael, Mosley, Jonathan D., Kawai, Vivian K.

“…Some autoimmune (AI) conditions affect white blood cell (WBC) counts. Whether a genetic predisposition to AI disease associates with WBC counts in populations…”
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Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry by Jiang, Lan, Gangireddy, Srushti, Dickson, Alyson L., Xin, Yi, Yan, Chao, Kawai, Vivian, Cox, Nancy J., Linton, MacRae F., Wei, Wei-Qi, Stein, C. Michael, Feng, QiPing

“…Hypertriglyceridemia (HTG) is a common cardiovascular risk factor characterized by elevated triglyceride (TG) levels. Researchers have assessed the genetic…”
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Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process by Caudle, Kelly E, Klein, Teri E, Hoffman, James M, Muller, Daniel J, Whirl-Carrillo, Michelle, Gong, Li, McDonagh, Ellen M, Sangkuhl, Katrin, Thorn, Caroline F, Schwab, Matthias, Agundez, Jose A G, Freimuth, Robert R, Huser, Vojtech, Lee, Ming Ta Michael, Iwuchukwu, Otito F, Crews, Kristine R, Scott, Stuart A, Wadelius, Mia, Swen, Jesse J, Tyndale, Rachel F, Stein, C Michael, Roden, Dan, Relling, Mary V, Williams, Marc S, Johnson, Samuel G

“…The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes genotype-based drug guidelines to help clinicians understand how available genetic…”
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Heart Failure Risk Associated With Rheumatoid Arthritis-Related Chronic Inflammation by Ahlers, Michael J, Lowery, Brandon D, Farber-Eger, Eric, Wang, Thomas J, Bradham, William, Ormseth, Michelle J, Chung, Cecilia P, Stein, C Michael, Gupta, Deepak K

“…Background Inflammation may contribute to incident heart failure (HF). Rheumatoid arthritis (RA), a prototypic inflammatory condition, may serve as a model for…”
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CYP2D6 genotype and reduced codeine analgesic effect in real-world clinical practice by Carranza-Leon, Daniel, Dickson, Alyson L., Gaedigk, Andrea, Stein, C. Michael, Chung, Cecilia P.

“…Cytochrome P450 2D6 (CYP2D6) O-demethylates codeine to the active drug, morphine. However, the utility of testing for CYP2D6 metabolizer status in patients…”
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Plasma miRNAs improve the prediction of coronary atherosclerosis in patients with rheumatoid arthritis by Ormseth, Michelle J., Solus, Joseph F., Sheng, Quanhu, Chen, Sheau-Chiann, Ye, Fei, Wu, Qiong, Oeser, Annette M., Allen, Ryan, Raggi, Paolo, Vickers, Kasey C., Stein, C. Michael

“…Objective MicroRNAs (miRNAs) regulate gene expression and are disease biomarkers. Rheumatoid arthritis (RA) patients have accelerated atherosclerosis leading…”
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