Search Results - "STEGMEIER, Frank"

Quantitative Proteomics of the Cancer Cell Line Encyclopedia by Nusinow, David P., Szpyt, John, Ghandi, Mahmoud, Rose, Christopher M., McDonald, E. Robert, Kalocsay, Marian, Jané-Valbuena, Judit, Gelfand, Ellen, Schweppe, Devin K., Jedrychowski, Mark, Golji, Javad, Porter, Dale A., Rejtar, Tomas, Wang, Y. Karen, Kryukov, Gregory V., Stegmeier, Frank, Erickson, Brian K., Garraway, Levi A., Sellers, William R., Gygi, Steven P.

“…Proteins are essential agents of biological processes. To date, large-scale profiling of cell line collections including the Cancer Cell Line Encyclopedia…”
Get full text

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition by Hata, Aaron N, Niederst, Matthew J, Archibald, Hannah L, Gomez-Caraballo, Maria, Siddiqui, Faria M, Mulvey, Hillary E, Maruvka, Yosef E, Ji, Fei, Bhang, Hyo-eun C, Krishnamurthy Radhakrishna, Viveksagar, Siravegna, Giulia, Hu, Haichuan, Raoof, Sana, Lockerman, Elizabeth, Kalsy, Anuj, Lee, Dana, Keating, Celina L, Ruddy, David A, Damon, Leah J, Crystal, Adam S, Costa, Carlotta, Piotrowska, Zofia, Bardelli, Alberto, Iafrate, Anthony J, Sadreyev, Ruslan I, Stegmeier, Frank, Getz, Gad, Sequist, Lecia V, Faber, Anthony C, Engelman, Jeffrey A

“…Drug-tolerant but initially EGFR T790M -negative tumor cells that undergo genetic evolution to acquire resistance to EGFR inhibitors are more resistant than…”
Get full text

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding by Bhang, Hyo-eun C, Ruddy, David A, Krishnamurthy Radhakrishna, Viveksagar, Caushi, Justina X, Zhao, Rui, Hims, Matthew M, Singh, Angad P, Kao, Iris, Rakiec, Daniel, Shaw, Pamela, Balak, Marissa, Raza, Alina, Ackley, Elizabeth, Keen, Nicholas, Schlabach, Michael R, Palmer, Michael, Leary, Rebecca J, Chiang, Derek Y, Sellers, William R, Michor, Franziska, Cooke, Vesselina G, Korn, Joshua M, Stegmeier, Frank

“…The authors have developed a barcoded library that enables the high-throughput tracking of tumor cell dynamics and clonal evolution in response to therapy…”
Get full text

An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide) by Korpal, Manav, Korn, Joshua M, Gao, Xueliang, Rakiec, Daniel P, Ruddy, David A, Doshi, Shivang, Yuan, Jing, Kovats, Steve G, Kim, Sunkyu, Cooke, Vesselina G, Monahan, John E, Stegmeier, Frank, Roberts, Thomas M, Sellers, William R, Zhou, Wenlai, Zhu, Ping

“…Castration-resistant prostate cancer (CRPC) is the most aggressive, incurable form of prostate cancer. MDV3100 (enzalutamide), an antagonist of the androgen…”
Get more information

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions by Munoz, Diana M, Cassiani, Pamela J, Li, Li, Billy, Eric, Korn, Joshua M, Jones, Michael D, Golji, Javad, Ruddy, David A, Yu, Kristine, McAllister, Gregory, DeWeck, Antoine, Abramowski, Dorothee, Wan, Jessica, Shirley, Matthew D, Neshat, Sarah Y, Rakiec, Daniel, de Beaumont, Rosalie, Weber, Odile, Kauffmann, Audrey, McDonald, 3rd, E Robert, Keen, Nicholas, Hofmann, Francesco, Sellers, William R, Schmelzle, Tobias, Stegmeier, Frank, Schlabach, Michael R

“…CRISPR/Cas9 has emerged as a powerful new tool to systematically probe gene function. We compared the performance of CRISPR to RNAi-based loss-of-function…”
Get more information

KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer by Krall, Elsa B, Wang, Belinda, Munoz, Diana M, Ilic, Nina, Raghavan, Srivatsan, Niederst, Matthew J, Yu, Kristine, Ruddy, David A, Aguirre, Andrew J, Kim, Jong Wook, Redig, Amanda J, Gainor, Justin F, Williams, Juliet A, Asara, John M, Doench, John G, Janne, Pasi A, Shaw, Alice T, McDonald Iii, Robert E, Engelman, Jeffrey A, Stegmeier, Frank, Schlabach, Michael R, Hahn, William C

“…Inhibitors that target the receptor tyrosine kinase (RTK)/Ras/mitogen-activated protein kinase (MAPK) pathway have led to clinical responses in lung and other…”
Get full text

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers by Hoffman, Gregory R., Rahal, Rami, Buxton, Frank, Xiang, Kay, McAllister, Gregory, Frias, Elizabeth, Bagdasarian, Linda, Huber, Janina, Lindeman, Alicia, Chen, Dongshu, Romero, Rodrigo, Ramadan, Nadire, Phadke, Tanushree, Haas, Kristy, Jaskelioff, Mariela, Wilson, Boris G., Meyer, Matthew J., Saenz-Vash, Veronica, Zhai, Huili, Myer, Vic E., Porter, Jeffrey A., Keen, Nicholas, McLaughlin, Margaret E., Mickanin, Craig, Roberts, Charles W. M., Stegmeier, Frank, Jagani, Zainab

“…Defects in epigenetic regulation play a fundamental role in the development of cancer, and epigenetic regulators have recently emerged as promising therapeutic…”
Get full text

Closing mitosis: the functions of the Cdc14 phosphatase and its regulation by Stegmeier, Frank, Amon, Angelika

“…Completion of the cell cycle requires the temporal and spatial coordination of chromosome segregation with mitotic spindle disassembly and cytokinesis. In…”
Get full text

PTEN-deficient cancers depend on PIK3CB by Wee, Susan, Wiederschain, Dmitri, Maira, Sauveur-Michel, Loo, Alice, Miller, Christine, deBeaumont, Rosalie, Stegmeier, Frank, Yao, Yung-Mae, Lengauer, Christoph

“…Deregulation of the PI3K signaling pathway is observed in many human cancers and occurs most frequently through loss of PTEN phosphatase tumor suppressor…”
Get full text

PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers by Wee, Susan, Jagani, Zainab, Xiang, Kay Xiaoqin, Loo, Alice, Dorsch, Marion, Yao, Yung-Mae, Sellers, William R, Lengauer, Christoph, Stegmeier, Frank

“…The RAS pathway is one of the most frequently deregulated pathways in cancer. RAS signals through multiple effector pathways, including the…”
Get full text

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells by Wang, Yubao, Lee, Young-Mi, Baitsch, Lukas, Huang, Alan, Xiang, Yi, Tong, Haoxuan, Lako, Ana, Von, Thanh, Choi, Christine, Lim, Elgene, Min, Junxia, Li, Li, Stegmeier, Frank, Schlegel, Robert, Eck, Michael J, Gray, Nathanael S, Mitchison, Timothy J, Zhao, Jean J

“…Despite marked advances in breast cancer therapy, basal-like breast cancer (BBC), an aggressive subtype of breast cancer usually lacking estrogen and…”
Get full text

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia by Jaffe, Jacob D, Wang, Yan, Chan, Ho Man, Zhang, Jinghui, Huether, Robert, Kryukov, Gregory V, Bhang, Hyo-eun C, Taylor, Jordan E, Hu, Min, Englund, Nathan P, Yan, Feng, Wang, Zhaofu, Robert McDonald, E, Wei, Lei, Ma, Jing, Easton, John, Yu, Zhengtian, deBeaumount, Rosalie, Gibaja, Veronica, Venkatesan, Kavitha, Schlegel, Robert, Sellers, William R, Keen, Nicholas, Liu, Jun, Caponigro, Giordano, Barretina, Jordi, Cooke, Vesselina G, Mullighan, Charles, Carr, Steven A, Downing, James R, Garraway, Levi A, Stegmeier, Frank

“…Frank Stegmeier, Levi Garraway and colleagues apply a targeted mass spectrometry approach that measures level of histone modifications and identify a recurrent…”
Get full text

Cdc14 and Condensin Control the Dissolution of Cohesin-Independent Chromosome Linkages at Repeated DNA by D'Amours, Damien, Stegmeier, Frank, Amon, Angelika

“…Chromosome segregation is triggered by the cleavage of cohesins by separase. Here we show that in budding yeast separation of the ribosomal DNA (rDNA) and…”
Get full text

A Lentiviral MicroRNA-Based System for Single-Copy Polymerase II-Regulated RNA Interference in Mammalian Cells by Stegmeier, Frank, Hu, Guang, Rickles, Richard J., Hannon, Gregory J., Elledge, Stephen J.

“…The advent of RNA interference has led to the ability to interfere with gene expression and greatly expanded our ability to perform genetic screens in…”
Get full text

Inhibition of Casein Kinase 1 Alpha Prevents Acquired Drug Resistance to Erlotinib in EGFR-Mutant Non-Small Cell Lung Cancer by Lantermann, Alexandra B, Chen, Dongshu, McCutcheon, Kaitlin, Hoffman, Greg, Frias, Elizabeth, Ruddy, David, Rakiec, Daniel, Korn, Joshua, McAllister, Gregory, Stegmeier, Frank, Meyer, Matthew J, Sharma, Sreenath V

“…Patients with lung tumors harboring activating mutations in the EGF receptor (EGFR) show good initial treatment responses to the EGFR tyrosine kinase…”
Get full text

Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts by Kuiken, Hendrik J., Dhakal, Sabin, Selfors, Laura M., Friend, Chandler M., Zhang, Tian, Callari, Maurizio, Schackmann, Ron C. J., Gray, G. Kenneth, Crowdis, Jett, Bhang, Hyo-eun C., Baslan, Timour, Stegmeier, Frank, Gygi, Steven P., Caldas, Carlos, Brugge, Joan S.

“…Intratumoral heterogeneity has been described for various tumor types and models of human cancer, and can have profound effects on tumor progression and drug…”
Get full text

Protein Kinase C Inhibitor Sotrastaurin Selectively Inhibits the Growth of CD79 Mutant Diffuse Large B-Cell Lymphomas by NAYLOR, Tara L, HUAPING TANG, YAO, Yung-Mae, WARMUTH, Markus, LENZ, Georg, STEGMEIER, Frank, RATSCH, Boris A, ENNS, Andreas, LOO, Alice, LIQING CHEN, LENZ, Peter, WATERS, Nigel J, SCHULER, Walter, DÖRKEN, Bernd

“…The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) correlates with poor prognosis. The ABC subtype of DLBCL is associated with…”
Get full text

Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/β-catenin signaling by Scholer-Dahirel, Alix, Schlabach, Michael R, Loo, Alice, Bagdasarian, Linda, Meyer, Ronald, Guo, Ribo, Woolfenden, Steve, Yu, Kristine K, Markovits, Judit, Killary, Karen, Sonkin, Dmitry, Yao, Yung-Mae, Warmuth, Markus, Sellers, William R, Schlegel, Robert, Stegmeier, Frank, Mosher, Rebecca E, McLaughlin, Margaret E

“…Persistent expression of certain oncogenes is required for tumor maintenance. This phenotype is referred to as oncogene addiction and has been clinically…”
Get full text

tumor suppressor CYLD regulates entry into mitosis by Stegmeier, Frank, Sowa, Mathew E, Nalepa, Grzegorz, Gygi, Steven P, Harper, J. Wade, Elledge, Stephen J

“…Mutations in the cylindromatosis (CYLD) gene cause benign tumors of skin appendages, referred to as cylindromas. The CYLD gene encodes a deubiquitinating…”
Get full text

Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells by Wang, Yubao, Li, Young-Mi, Baitsch, Lukas, Huang, Alan, Xiang, Yi, Tong, Haoxuan, Lako, Ana, Von, Thanh, Choi, Christine, Lim, Elgene, Min, Junxia, Li, Li, Stegmeier, Frank, Schlegel, Robert, Eck, Michael J, Gray, Nathanael S, Mitchison, Timothy J, Zhao, Jean J

Get full text