Search Results - "STAUDT, Louis M"

Toward a Shared Vision for Cancer Genomic Data by Grossman, Robert L, Heath, Allison P, Ferretti, Vincent, Varmus, Harold E, Lowy, Douglas R, Kibbe, Warren A, Staudt, Louis M

“…The Genomic Data Commons will initially house raw genomic data and diagnostic, histologic, and clinical outcome data from National Cancer Institute–funded…”
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The next horizon in precision oncology: Proteogenomics to inform cancer diagnosis and treatment by Rodriguez, Henry, Zenklusen, Jean Claude, Staudt, Louis M., Doroshow, James H., Lowy, Douglas R.

“…When it comes to precision oncology, proteogenomics may provide better prospects to the clinical characterization of tumors, help make a more accurate…”
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Burkitt’s Lymphoma by Roschewski, Mark, Staudt, Louis M., Wilson, Wyndham H.

“…Burkitt’s lymphoma is a rapidly proliferating lymphoma of germinal-center B cells. Most patients are cured with chemotherapy and prevention of tumor lysis…”
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The NCI Genomic Data Commons as an engine for precision medicine by Jensen, Mark A., Ferretti, Vincent, Grossman, Robert L., Staudt, Louis M.

“…The National Cancer Institute Genomic Data Commons (GDC) is an information system for storing, analyzing, and sharing genomic and clinical data from patients…”
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Pathogenic B‐cell receptor signaling in lymphoid malignancies: New insights to improve treatment by Young, Ryan M., Phelan, James D., Wilson, Wyndham H., Staudt, Louis M.

“…Signals emanating from the B‐cell receptor (BCR) promote proliferation and survival in diverse forms of B‐cell lymphoma. Precision medicine strategies…”
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Uniform genomic data analysis in the NCI Genomic Data Commons by Zhang, Zhenyu, Hernandez, Kyle, Savage, Jeremiah, Li, Shenglai, Miller, Dan, Agrawal, Stuti, Ortuno, Francisco, Staudt, Louis M., Heath, Allison, Grossman, Robert L.

“…The goal of the National Cancer Institute’s (NCI’s) Genomic Data Commons (GDC) is to provide the cancer research community with a data repository of uniformly…”
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Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma by Lionakis, Michail S., Dunleavy, Kieron, Roschewski, Mark, Widemann, Brigitte C., Butman, John A., Schmitz, Roland, Yang, Yandan, Cole, Diane E., Melani, Christopher, Higham, Christine S., Desai, Jigar V., Ceribelli, Michele, Chen, Lu, Thomas, Craig J., Little, Richard F., Gea-Banacloche, Juan, Bhaumik, Sucharita, Stetler-Stevenson, Maryalice, Pittaluga, Stefania, Jaffe, Elaine S., Heiss, John, Lucas, Nicole, Steinberg, Seth M., Staudt, Louis M., Wilson, Wyndham H.

“…Primary CNS lymphoma (PCNSL) harbors mutations that reinforce B cell receptor (BCR) signaling. Ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, targets…”
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Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma by Yang, Yibin, Shaffer, Arthur L., Emre, N.C. Tolga, Ceribelli, Michele, Zhang, Meili, Wright, George, Xiao, Wenming, Powell, John, Platig, John, Kohlhammer, Holger, Young, Ryan M., Zhao, Hong, Yang, Yandan, Xu, Weihong, Buggy, Joseph J., Balasubramanian, Sriram, Mathews, Lesley A., Shinn, Paul, Guha, Rajarshi, Ferrer, Marc, Thomas, Craig, Waldmann, Thomas A., Staudt, Louis M.

“…Knowledge of oncogenic mutations can inspire therapeutic strategies that are synthetically lethal, affecting cancer cells while sparing normal cells…”
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B-Cell Receptor Signaling in Diffuse Large B-Cell lymphoma by Young, Ryan M, Shaffer, Arthur L, Phelan, James D, Staudt, Louis M

“…The importance of understanding the genetic and biochemical basis of B-cell receptor (BCR) survival signaling in diffuse large B-cell lymphoma (DLBCL) is…”
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Most non-canonical proteins uniquely populate the proteome or immunopeptidome by Ruiz Cuevas, Maria Virginia, Hardy, Marie-Pierre, Hollý, Jaroslav, Bonneil, Éric, Durette, Chantal, Courcelles, Mathieu, Lanoix, Joël, Côté, Caroline, Staudt, Louis M., Lemieux, Sébastien, Thibault, Pierre, Perreault, Claude, Yewdell, Jonathan W.

“…Combining RNA sequencing, ribosome profiling, and mass spectrometry, we elucidate the contribution of non-canonical translation to the proteome and major…”
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Control of Autophagic Cell Death by Caspase-10 in Multiple Myeloma by Lamy, Laurence, Ngo, Vu N., Emre, N.C. Tolga, Shaffer, Arthur L., Yang, Yandan, Tian, Erming, Nair, Vinod, Kruhlak, Michael J., Zingone, Adriana, Landgren, Ola, Staudt, Louis M.

“…We performed a loss-of-function RNA interference screen to define therapeutic targets in multiple myeloma, a genetically diverse plasma cell malignancy…”
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Pathogenesis of Human B Cell Lymphomas by Shaffer, Arthur L, Young, Ryan M, Staudt, Louis M

“…The mechanisms that drive normal B cell differentiation and activation are frequently subverted by B cell lymphomas for their unlimited growth and survival. B…”
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Dynamic monitoring of circulating tumor DNA in non-Hodgkin lymphoma by Roschewski, Mark, Staudt, Louis M., Wilson, Wyndham H.

“…Response assessment in lymphoma relies on imaging scans that do not capture biologic processes at the molecular level. Monitoring circulating tumor DNA (ctDNA)…”
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Prognostic Significance of Diffuse Large B-Cell Lymphoma Cell of Origin Determined by Digital Gene Expression in Formalin-Fixed Paraffin-Embedded Tissue Biopsies by Scott, David W, Mottok, Anja, Ennishi, Daisuke, Wright, George W, Farinha, Pedro, Ben-Neriah, Susana, Kridel, Robert, Barry, Garrett S, Hother, Christoffer, Abrisqueta, Pau, Boyle, Merrill, Meissner, Barbara, Telenius, Adele, Savage, Kerry J, Sehn, Laurie H, Slack, Graham W, Steidl, Christian, Staudt, Louis M, Connors, Joseph M, Rimsza, Lisa M, Gascoyne, Randy D

“…To evaluate the prognostic impact of cell-of-origin (COO) subgroups, assigned using the recently described gene expression-based Lymph2Cx assay in comparison…”
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Circulating tumour DNA and CT monitoring in patients with untreated diffuse large B-cell lymphoma: a correlative biomarker study by Roschewski, Mark, MD, Dunleavy, Kieron, MD, Pittaluga, Stefania, MD-PhD, Moorhead, Martin, PhD, Pepin, Francois, PhD, Kong, Katherine, MS, Shovlin, Margaret, RN, Jaffe, Elaine S, MD, Staudt, Louis M, MD-PhD, Lai, Catherine, MD, Steinberg, Seth M, PhD, Chen, Clara C, MD, Zheng, Jianbiao, PhD, Willis, Thomas D, PhD, Faham, Malek, MD-PhD, Wilson, Wyndham H, Dr

“…Summary Background Diffuse large-B-cell lymphoma is curable, but when treatment fails, outcome is poor. Although imaging can help to identify patients at risk…”
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Genome-wide Screens Identify Lineage- and Tumor-Specific Genes Modulating MHC-I- and MHC-II-Restricted Immunosurveillance of Human Lymphomas by Dersh, Devin, Phelan, James D., Gumina, Megan E., Wang, Boya, Arbuckle, Jesse H., Holly, Jaroslav, Kishton, Rigel J., Markowitz, Tovah E., Seedhom, Mina O., Fridlyand, Nathan, Wright, George W., Huang, Da Wei, Ceribelli, Michele, Thomas, Craig J., Lack, Justin B., Restifo, Nicholas P., Kristie, Thomas M., Staudt, Louis M., Yewdell, Jonathan W.

“…Tumors frequently subvert major histocompatibility complex class I (MHC-I) peptide presentation to evade CD8+ T cell immunosurveillance, though how this is…”
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Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy by Kelly, Priscilla N, Romero, Donna L, Yang, Yibin, Shaffer, 3rd, Arthur L, Chaudhary, Divya, Robinson, Shaughnessy, Miao, Wenyan, Rui, Lixin, Westlin, William F, Kapeller, Rosana, Staudt, Louis M

“…Pathological activation of the Toll-like receptor signaling adaptor protein MYD88 underlies many autoimmune and inflammatory disease states. In the activated B…”
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Determining cell-of-origin subtypes of diffuse large B-cell lymphoma using gene expression in formalin-fixed paraffin-embedded tissue by Scott, David W., Wright, George W., Williams, P. Mickey, Lih, Chih-Jian, Walsh, William, Jaffe, Elaine S., Rosenwald, Andreas, Campo, Elias, Chan, Wing C., Connors, Joseph M., Smeland, Erlend B., Mottok, Anja, Braziel, Rita M., Ott, German, Delabie, Jan, Tubbs, Raymond R., Cook, James R., Weisenburger, Dennis D., Greiner, Timothy C., Glinsmann-Gibson, Betty J., Fu, Kai, Staudt, Louis M., Gascoyne, Randy D., Rimsza, Lisa M.

“…The assignment of diffuse large B-cell lymphoma into cell-of-origin (COO) groups is becoming increasingly important with the emergence of novel therapies that…”
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A Druggable TCF4- and BRD4-Dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm by Ceribelli, Michele, Hou, Zhiying Esther, Kelly, Priscilla N., Huang, Da Wei, Wright, George, Ganapathi, Karthik, Evbuomwan, Moses O., Pittaluga, Stefania, Shaffer, Arthur L., Marcucci, Guido, Forman, Stephen J., Xiao, Wenming, Guha, Rajarshi, Zhang, Xiaohu, Ferrer, Marc, Chaperot, Laurence, Plumas, Joel, Jaffe, Elaine S., Thomas, Craig J., Reizis, Boris, Staudt, Louis M.

“…Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive and largely incurable hematologic malignancy originating from plasmacytoid dendritic…”
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Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens by Young, Ryan M., Wu, Tianyi, Schmitz, Roland, Dawood, Moez, Xiao, Wenming, Phelan, James D., Xu, Weihong, Menard, Laurence, Meffre, Eric, Chan, Wing-Chung C., Jaffe, Elaine S., Gascoyne, Randy D., Campo, Elías, Rosenwald, Andreas, Ott, German, Delabie, Jan, Rimsza, Lisa M., Staudt, Louis M.

“…The activated B-cell–like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) relies on chronic active B-cell receptor (BCR) signaling. BCR pathway…”
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