Search Results - "STATNICK, Michael A"

The Thermogenic Effect of Leptin Is Dependent on a Distinct Population of Prolactin-Releasing Peptide Neurons in the Dorsomedial Hypothalamus by Dodd, Garron T., Worth, Amy A., Nunn, Nicolas, Korpal, Aaron K., Bechtold, David A., Allison, Margaret B., Myers, Martin G., Statnick, Michael A., Luckman, Simon M.

“…Leptin is a critical regulator of metabolism, which acts on brain receptors (Lepr) to reduce energy intake and increase energy expenditure. Some of the…”
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The current state of GPCR‐based drug discovery to treat metabolic disease by Sloop, Kyle W, Emmerson, Paul J, Statnick, Michael A, Willard, Francis S

“…One approach of modern drug discovery is to identify agents that enhance or diminish signal transduction cascades in various cell types and tissues by…”
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The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors by Cook, Chris, Nunn, Nicolas, Worth, Amy A, Bechtold, David A, Suter, Todd, Gackeheimer, Susan, Foltz, Lisa, Emmerson, Paul J, Statnick, Michael A, Luckman, Simon M

“…Here we show that central administration of pyroglutamylated arginine-phenylamine-amide peptide (QRFP/26RFa) increases both food intake and locomotor activity,…”
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Development of LC-MS/MS-Based Receptor Occupancy Tracers and Positron Emission Tomography Radioligands for the Nociceptin/Orphanin FQ (NOP) Receptor by Pedregal, Concepción, Joshi, Elizabeth M, Toledo, Miguel A, Lafuente, Celia, Diaz, Nuria, Martinez-Grau, Maria A, Jiménez, Alma, Benito, Ana, Navarro, Antonio, Chen, Zhaogen, Mudra, Daniel R, Kahl, Steven D, Rash, Karen S, Statnick, Michael A, Barth, Vanessa N

“…Currently, a lack of sufficient tools has limited the understanding of the relationship between neuropsychiatric disorders and the nociceptin/orphanin FQ…”
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The biology of Nociceptin/Orphanin FQ(N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence by WITKIN, Jeffrey M, STATNICK, Michael A, RORICK-KEHN, Linda M, PINTAR, John E, ANSONOFF, Michael, YANYUN CHEN, TUCKER, R. Craig, CICCOCIOPPO, Roberto

“…Nociceptin/Orphanin FQ (N/OFQ) is a 17 amino acid peptide that was deorphanized in 1995. The generation of specific agonists, antagonists and receptor…”
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Genetic Deletion of the Nociceptin/Orphanin FQ Receptor in the Rat Confers Resilience to the Development of Drug Addiction by Kallupi, Marsida, Scuppa, Giulia, de Guglielmo, Giordano, Calò, Girolamo, Weiss, Friedbert, Statnick, Michael A, Rorick-Kehn, Linda M, Ciccocioppo, Roberto

“…The nociceptin (NOP) receptor is a G-protein-coupled receptor whose natural ligand is the NOP/orphanin FQ (N/OFQ) peptide. Evidence from pharmacological…”
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Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats by Shannon, Harlan E., Eberle, Elizabeth L., Mitch, Charles H., McKinzie, David L., Statnick, Michael A.

“…In humans, kappa opioid receptor agonists produce, among other effects, sedation and difficulty concentrating, suggesting that they may disrupt attention. The…”
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A Model of Binge-Like Eating Behavior in Mice That Does Not Require Food Deprivation or Stress by Czyzyk, Traci A., Sahr, Allison E., Statnick, Michael A.

“…Binge eating disorder (BED) is characterized by excessive food intake during a short period of time and is often associated with obesity. Mouse models of…”
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LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders by Rorick-Kehn, Linda M., Witkin, Jeffrey M., Statnick, Michael A., Eberle, Elizabeth L., McKinzie, Jamie H., Kahl, Steven D., Forster, Beth M., Wong, Conrad J., Li, Xia, Crile, Robert S., Shaw, David B., Sahr, Allison E., Adams, Benjamin L., Quimby, Steven J., Diaz, Nuria, Jimenez, Alma, Pedregal, Concepcion, Mitch, Charles H., Knopp, Kelly L., Anderson, Wesley H., Cramer, Jeffrey W., McKinzie, David L.

“…Kappa opioid receptors and their endogenous neuropeptide ligand, dynorphin A, are densely localized in limbic and cortical areas comprising the brain reward…”
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Mice lacking δ‐opioid receptors resist the development of diet‐induced obesity by Czyzyk, Traci A., Romero‐Picó, Amparo, Pintar, John, McKinzie, Jaime H., Tschöp, Matthias H., Statnick, Michael A., Nogueiras, Ruben

“…ABSTRACT Pharmacological manipulation of opioid receptors alters feeding behavior. However, the individual contributions of each opioid receptor subtype on…”
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A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models by Rorick-Kehn, Linda M., Ciccocioppo, Roberto, Wong, Conrad J., Witkin, Jeffrey M., Martinez-Grau, Maria A., Stopponi, Serena, Adams, Benjamin L., Katner, Jason S., Perry, Kenneth W., Toledo, Miguel A., Diaz, Nuria, Lafuente, Celia, Jiménez, Alma, Benito, Ana, Pedregal, Concepción, Weiss, Friedbert, Statnick, Michael A.

“…Background The nociceptin/orphanin‐FQ (or opioid receptor‐like [ORL1]) receptor (NOP) is localized in the mesolimbic reward pathway and has been suggested to…”
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A Novel Nociceptin Receptor Antagonist LY2940094 Inhibits Excessive Feeding Behavior in Rodents: A Possible Mechanism for the Treatment of Binge Eating Disorder by Statnick, Michael A, Chen, Yanyun, Ansonoff, Michael, Witkin, Jeffrey M, Rorick-Kehn, Linda, Suter, Todd M, Song, Min, Hu, Charlie, Lafuente, Celia, Jiménez, Alma, Benito, Ana, Diaz, Nuria, Martínez-Grau, Maria Angeles, Toledo, Miguel A, Pintar, John E

“…Nociceptin/orphanin FQ (N/OFQ), a 17 amino acid peptide, is the endogenous ligand of the ORL1/nociceptin-opioid-peptide (NOP) receptor. N/OFQ appears to…”
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Occupancy of Nociceptin/Orphanin FQ Peptide Receptors by the Antagonist LY2940094 in Rats and Healthy Human Subjects by Raddad, Eyas, Chappell, Amy, Meyer, Jeffery, Wilson, Alan, Ruegg, Charles E, Tauscher, Johannes, Statnick, Michael A, Barth, Vanessa, Zhang, Xin, Verfaille, Steven J

“…Therapeutic benefits from nociceptin opioid peptide receptor (NOP) antagonism were proposed for obesity, eating disorders, and depression. LY2940094…”
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Discovery of Aminobenzyloxyarylamides as κ Opioid Receptor Selective Antagonists: Application to Preclinical Development of a κ Opioid Receptor Antagonist Receptor Occupancy Tracer by Mitch, Charles H, Quimby, Steven J, Diaz, Nuria, Pedregal, Concepcion, de la Torre, Marta G, Jimenez, Alma, Shi, Qing, Canada, Emily J, Kahl, Steven D, Statnick, Michael A, McKinzie, David L, Benesh, Dana R, Rash, Karen S, Barth, Vanessa N

“…Arylphenylpyrrolidinylmethylphenoxybenzamides were found to have high affinity and selectivity for κ opioid receptors. On the basis of receptor binding assays…”
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Regulation of Endogenous (Male) Rodent GLP-1 Secretion and Human Islet Insulin Secretion by Antagonism of Somatostatin Receptor 5 by Farb, Thomas B, Adeva, Marta, Beauchamp, Thomas J, Cabrera, Over, Coates, David A, Meredith, Tamika DeShea, Droz, Brian A, Efanov, Alexander, Ficorilli, James V, Gackenheimer, Susan L, Martinez-Grau, Maria A, Molero, Victoriano, Ruano, Gema, Statnick, Michael A, Suter, Todd M, Syed, Samreen K, Toledo, Miguel A, Willard, Francis S, Zhou, Xin, Bokvist, Krister B, Barrett, David G

“…Incretin and insulin responses to nutrient loads are suppressed in persons with diabetes, resulting in decreased glycemic control. Agents including…”
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Na + modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists by Emmerson, Paul J, McKinzie, Jamie H, Surface, Peggy L, Suter, Todd M, Mitch, Charles H, Statnick, Michael A

“…Differences in the anorectic activity of morphinan (e.g., naltrexone) and 3,4-dimethyl-4-(3-hydroxyphenyl)piperidine (4PP) opioid receptor antagonists have…”
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An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis by Svensson, Kjell A, Heinz, Beverly A, Schaus, John M, Beck, James P, Hao, Junliang, Krushinski, Joseph H, Reinhard, Matthew R, Cohen, Michael P, Hellman, Sarah L, Getman, Brian G, Wang, Xushan, Menezes, Michelle M, Maren, Deanna L, Falcone, Julie F, Anderson, Wesley H, Wright, Rebecca A, Morin, S Michelle, Knopp, Kelly L, Adams, Benjamin L, Rogovoy, Borys, Okun, Ilya, Suter, Todd M, Statnick, Michael A, Gehlert, Donald R, Nelson, David L, Lucaites, Virginia L, Emkey, Renee, DeLapp, Neil W, Wiernicki, Todd R, Cramer, Jeffrey W, Yang, Charles R, Bruns, Robert F

“…Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis…”
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Discovery of a Novel Series of Orally Active Nociceptin/Orphanin FQ (NOP) Receptor Antagonists Based on a Dihydrospiro(piperidine-4,7′-thieno[2,3‑c]pyran) Scaffold by Toledo, Miguel A, Pedregal, Concepción, Lafuente, Celia, Diaz, Nuria, Martinez-Grau, Maria Angeles, Jiménez, Alma, Benito, Ana, Torrado, Alicia, Mateos, Carlos, Joshi, Elizabeth M, Kahl, Steven D, Rash, Karen S, Mudra, Daniel R, Barth, Vanessa N, Shaw, David B, McKinzie, David, Witkin, Jeffrey M, Statnick, Michael A

“…Nociceptin/OFQ (N/OFQ) is a 17 amino acid peptide that is the endogenous ligand for the ORL1/NOP receptor. Nociceptin appears to regulate a host of…”
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κ‐Opioid receptors control the metabolic response to a high‐energy diet in mice by Czyzyk, Traci A., Nogueiras, Ruben, Lockwood, John F., McKinzie, Jamie H., Coskun, Tamer, Pintar, John E., Hammond, Craig, Tschöp, Matthias H., Statnick, Michael A.

“…ABSTRACT General opioid receptor antagonists reduce food intake and body weight in rodents, but the contributions of specific receptor subtypes are unknown. We…”
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Nociceptin/orphanin FQ suppresses the excitability of neurons in the ventromedial nucleus of the hypothalamus by Chee, Melissa J., Price, Christopher J., Statnick, Michael A., Colmers, William F.

“…Non‐technical summary  Feeding behaviour is controlled in part by activity within brain hypothalamic nuclei. The ventromedial nucleus of the hypothalamus (VMN)…”
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