Search Results - "STARR, Alexander"

Synaptic dysfunction and altered excitability in C9ORF72 ALS/FTD by Starr, Alexander, Sattler, Rita

“…•Aberrant RNA metabolism contributes to synaptic deficits in C9orf72 ALS/FTD.•There are common mechanisms of synaptic dysfunction amongst different subtypes of…”
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Accounting for cis-regulatory constraint prioritizes genes likely to affect species-specific traits by Starr, Alexander L, Gokhman, David, Fraser, Hunter B

“…Measuring allele-specific expression in interspecies hybrids is a powerful way to detect cis-regulatory changes underlying adaptation. However, it remains…”
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Cell-type-specific cis -regulatory divergence in gene expression and chromatin accessibility revealed by human-chimpanzee hybrid cells by Wang, Ban, Starr, Alexander L, Fraser, Hunter B

“…Although gene expression divergence has long been postulated to be the primary driver of human evolution, identifying the genes and genetic variants underlying…”
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ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD by Moore, Stephen, Alsop, Eric, Lorenzini, Ileana, Starr, Alexander, Rabichow, Benjamin E., Mendez, Emily, Levy, Jennifer L., Burciu, Camelia, Reiman, Rebecca, Chew, Jeannie, Belzil, Veronique V., W. Dickson, Dennis, Robertson, Janice, Staats, Kim A., Ichida, Justin K., Petrucelli, Leonard, Van Keuren-Jensen, Kendall, Sattler, Rita

“…The hexanucleotide repeat expansion GGGGCC (G 4 C 2 ) n in the C9orf72 gene is the most common genetic abnormality associated with amyotrophic lateral…”
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Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae by Starr, Alexander, Jordan-Sciutto, Kelly L, Mironets, Eugene

“…The persistence of human immunodeficiency virus-1 (HIV)-associated neurocognitive disorders (HAND) in the era of effective antiretroviral therapy suggests that…”
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Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS by Coyne, Alyssa N., Lorenzini, Ileana, Chou, Ching-Chieh, Torvund, Meaghan, Rogers, Robert S., Starr, Alexander, Zaepfel, Benjamin L., Levy, Jennifer, Johannesmeyer, Jeffrey, Schwartz, Jacob C., Nishimune, Hiroshi, Zinsmaier, Konrad, Rossoll, Wilfried, Sattler, Rita, Zarnescu, Daniela C.

“…Amyotrophic lateral sclerosis (ALS) is a synaptopathy accompanied by the presence of cytoplasmic aggregates containing TDP-43, an RNA-binding protein linked to…”
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Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS by Manzo, Ernesto, Lorenzini, Ileana, Barrameda, Dianne, O'Conner, Abigail G, Barrows, Jordan M, Starr, Alexander, Kovalik, Tina, Rabichow, Benjamin E, Lehmkuhl, Erik M, Shreiner, Dakotah D, Joardar, Archi, Liévens, Jean-Charles, Bowser, Robert, Sattler, Rita, Zarnescu, Daniela C

“…Amyotrophic Lateral Sclerosis (ALS), is a fatal neurodegenerative disorder, with TDP-43 inclusions as a major pathological hallmark. Using a model of TDP-43…”
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Representing Diversity in the Dish: Using Patient-Derived in Vitro Models to Recreate the Heterogeneity of Neurological Disease by Ghaffari, Layla T, Starr, Alexander, Nelson, Andrew T, Sattler, Rita

“…Neurological diseases, including dementias such as Alzheimer's disease (AD) and fronto-temporal dementia (FTD) and degenerative motor neuron diseases such as…”
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Human iPSC-derived neurons reveal NMDAR-independent dysfunction following HIV-associated insults by Starr, Alexander, Nickoloff-Bybel, Emily, Abedalthaqafi, Razan, Albloushi, Naela, Jordan-Sciutto, Kelly L

“…The central nervous system encounters a number of challenges following HIV infection, leading to increased risk for a collection of neurocognitive symptoms…”
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The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease by Bakkar, Nadine, Starr, Alexander, Rabichow, Benjamin E., Lorenzini, Ileana, McEachin, Zachary T., Kraft, Robert, Chaung, Matthew, Macklin-Isquierdo, Sam, Wingfield, Taylor, Carhart, Briggs, Zahler, Nathan, Chang, Wen-Hsuan, Bassell, Gary J., Betourne, Alexandre, Boulis, Nicholas, Alworth, Samuel V., Ichida, Justin K., August, Paul R., Zarnescu, Daniela C., Sattler, Rita, Bowser, Robert

“…Disruption in copper homeostasis causes a number of cognitive and motor deficits. Wilson's disease and Menkes disease are neurodevelopmental disorders…”
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Rh2-enriched Korean ginseng (Ginseng Rh2+) inhibits tumor growth and development of metastasis of non-small cell lung cancer by Lev-Ari, Shahar, Starr, Alexander N, Vexler, Akiva, Kalich-Philosoph, Lital, Yoo, Hwa-Seung, Kwon, Ki-Rok, Yadgar, Meital, Bondar, Ekaterina, Bar-Shai, Amir, Volovitz, Ilan, Schwarz, Yehuda

“…While there are multiple studies on the anti-tumoral effects of Panax ginseng as active ingredients (one or more ginsenosides derived from the extract) or as a…”
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Cell-type-specific cis-regulatory divergence in gene expression and chromatin accessibility revealed by human-chimpanzee hybrid cells by Wang, Ban, Starr, Alexander L, Fraser, Hunter B

“…Although gene expression divergence has long been postulated to be the primary driver of human evolution, identifying the genes and genetic variants underlying…”
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Sorafenib or Placebo with Either Gemcitabine or Capecitabine in Patients with HER-2―Negative Advanced Breast Cancer That Progressed during or after Bevacizumab by SCHWARTZBERG, Lee S, TAUER, Kurt W, BELL-MCGUINN, Katherine, KIRSHNER, Jeffrey J, EISENBERG, Peter, EMANUELSON, Richard, KEATON, Mark, LEVINE, Ellis, MEDGYESY, Diana C, QAMAR, Rubina, STARR, Alexander, SUNHEE KWON RO, HERMANN, Robert C, LOKKER, Nathalie A, HUDIS, Clifford A, MAKARI-JUDSON, Grace, ISAACS, Claudine, THADDEUS BECK, J, KAKLAMANI, Virginia, STEPANSKI, Edward J, RUGO, Hope S, WEI WANG

“…We assessed adding the multikinase inhibitor sorafenib to gemcitabine or capecitabine in patients with advanced breast cancer whose disease progressed…”
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Correction to: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD by Moore, Stephen, Alsop, Eric, Lorenzini, Ileana, Starr, Alexander, Rabichow, Benjamin E., Mendez, Emily, Levy, Jennifer L., Burciu, Camelia, Reiman, Rebecca, Chew, Jeannie, Belzil, Veronique V., Dickson, Dennis, Robertson, Janice, Staats, Kim A., Ichida, Justin K., Petrucelli, Leonard, Van Keuren-Jensen, Kendall, Sattler, Rita

“…The original article was published erroneously without mentioning the support of the U.S…”
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Quantitative measurement of HER2 expression in breast cancers: comparison with 'real-world' routine HER2 testing in a multicenter Collaborative Biomarker Study and correlation with overall survival by Yardley, Denise A, Kaufman, Peter A, Huang, Weidong, Krekow, Lea, Savin, Michael, Lawler, William E, Zrada, Stephen, Starr, Alexander, Einhorn, Harvey, Schwartzberg, Lee S, Adams, John W, Lie, Yolanda, Paquet, Agnes C, Sperinde, Jeff, Haddad, Mojgan, Anderson, Steve, Brigino, Marlon, Pesano, Rick, Bates, Michael P, Weidler, Jodi, Bosserman, Linda

“…Accurate assessment of HER2 status is critical in determining appropriate therapy for breast cancer patients but the best HER2 testing methodology has yet to…”
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Bortezomib (VELCADE), Rituximab, Cyclophosphamide, Dexamethasone (VRCD) Combination Therapy In Front-Line Low-Grade Non-Hodgkin Lymphoma (LG-NHL) Is Active In Elderly Patient Population by Nabhan, Chadi, Dalal, Neil, Tolzien, Kathy, Starr, Alexander

“…Abstract 1769 Rituximab (R) alone or R-based Chemoimmunotherapy programs have become the standard front-line approach for LG-NHL patients requiring therapeutic…”
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Bortezomib (Velcade), Rituximab, Cyclophosphamide, and Dexamethasone Combination Regimen Is Active as Front-Line Therapy of Low-Grade Non-Hodgkin Lymphoma by Nabhan, Chadi, Villines, Dana, Dalal, Neil, Tolzien, Kathy, Kozolff, Mark, Starr, Alexander

“…Micro-Abstract The best frontline regimen in low grade non Hodgkin lymphoma remains undefined. A phase II study combining bortezomib, rituximab,…”
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Phase II study of mitoxantrone and ketoconazole for hormone‐refractory prostate cancer by Eklund, John, Kozloff, Mark, Vlamakis, Joy, Starr, Alexander, Mariott, Margaret, Gallot, Lilia, Jovanovic, Borko, Schilder, Lawrence, Robin, Erwin, Pins, Michael, Bergan, Raymond C.

“…BACKGROUND Doxorubicin plus ketoconazole has exhibited significant activity in patients with advanced prostate cancer. However, overall and cardiac‐specific…”
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Cutaneous eruption related to human epidermal growth factor receptor inhibitors in stage IV colon cancer by Guzman, Lisa, Kozloff, Mark, Wallace, James, Starr, Alexander

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Hormone Replacement Therapy and High S Phase in Breast Cancer by Cobleigh, Melody A, Norlock, Frances E, Oleske, Denise M, Starr, Alexander

“…CONTEXT Prolonged postmenopausal hormone replacement therapy (HRT) is associated with increased incidence of breast cancer and, paradoxically, reduced breast…”
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