Search Results - "STAROSTIK, Petr"

CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial by Smith, D. Max, Weitzel, Kristin W., Elsey, Amanda R., Langaee, Taimour, Gong, Yan, Wake, Dyson T., Duong, Benjamin Q., Hagen, Melanie, Harle, Christopher A., Mercado, Elvira, Nagoshi, Ying, Newsom, Kimberly, Wright, Ashleigh, Rosenberg, Eric I., Starostik, Petr, Clare-Salzler, Michael J., Schmidt, Siegfried O., Fillingim, Roger B., Johnson, Julie A., Cavallari, Larisa H.

“…Purpose CYP2D6 bioactivates codeine and tramadol, with intermediate and poor metabolizers (IMs and PMs) expected to have impaired analgesia. This pragmatic…”
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Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer by Rotow, Julia K, Gui, Philippe, Wu, Wei, Raymond, Victoria M, Lanman, Richard B, Kaye, Frederic J, Peled, Nir, Fece de la Cruz, Ferran, Nadres, Brandon, Corcoran, Ryan B, Yeh, Iwei, Bastian, Boris C, Starostik, Petr, Newsom, Kimberly, Olivas, Victor R, Wolff, Alexander M, Fraser, James S, Collisson, Eric A, McCoach, Caroline E, Camidge, D Ross, Pacheco, Jose, Bazhenova, Lyudmila, Li, Tianhong, Bivona, Trever G, Blakely, Collin M

“…Although patients with advanced-stage non-small cell lung cancers (NSCLC) harboring exon 14 skipping mutations ( ex14) often benefit from MET tyrosine kinase…”
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Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study by Balch, Jeremy A, Chen, Uan-I, Liesenfeld, Oliver, Starostik, Petr, Loftus, Tyler J, Efron, Philip A, Brakenridge, Scott C, Sweeney, Timothy E, Moldawer, Lyle L

“…Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may…”
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SMARCA4-Deficient Thoracic Sarcoma: A Case Report and Review of Literature by Stewart, Brian D., Kaye, Frederic, Machuca, Tiago, Mehta, Hiren J., Mohammed, Tan-Lucien, Newsom, Kimberly J., Starostik, Petr

“…SMARCA4-deficient thoracic sarcoma (SMARCA4-DTS) is a recently described entity with a poor prognosis that is defined by certain genetic alterations in the BAF…”
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A hybrid implementation-effectiveness randomized trial of CYP2D6-guided postoperative pain management by Thomas, Cameron D., Parvataneni, Hari K., Gray, Chancellor F., Deen, Justin T., Prieto, Hernan A., Pulido, Luis F., Elsey, Amanda R., Elwood, Erica N., Starostik, Petr, Gong, Yan, Fillingim, Roger B., Johnson, Julie A., Cavallari, Larisa H.

“…Cytochrome P450 2D6 (CYP2D6) genotype–guided opioid prescribing is limited. The purpose of this type 2 hybrid implementation-effectiveness trial was to…”
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Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention by Cavallari, Larisa H, Franchi, Francesco, Rollini, Fabiana, Been, Latonya, Rivas, Andrea, Agarwal, Malhar, Smith, D Max, Newsom, Kimberly, Gong, Yan, Elsey, Amanda R, Starostik, Petr, Johnson, Julie A, Angiolillo, Dominick J

“…The CYP2C19 nonfunctional genotype reduces clopidogrel effectiveness after percutaneous coronary intervention (PCI). Following clinical implementation of…”
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Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis by Loftus, Tyler J, Ungaro, Ricardo, Dirain, Marvin, Efron, Philip A, Mazer, Monty B, Remy, Kenneth E, Hotchkiss, Richard S, Zhong, Luer, Bacher, Rhonda, Starostik, Petr, Moldawer, Lyle L, Brakenridge, Scott C

“…Both severe SARS-CoV-2 infections and bacterial sepsis exhibit an immunological dyscrasia and propensity for secondary infections. The nature of the…”
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P473: Reconciling medical genetics educational competencies and closing gaps in undergraduate medical education by Burnside, Rachel, Starostik, Petr, Boothe, Megan, Stalker, Heather, Trapane, Pamela

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Reimbursement of pharmacogenetic tests at a tertiary academic medical center in the United States by Lemke, Lauren K., Alam, Benish, Williams, Roy, Starostik, Petr, Cavallari, Larisa H., Cicali, Emily J., Wiisanen, Kristin

“…Introduction: Pharmacogenetics (PGx) has the potential to improve health outcomes but cost of testing is a barrier for equitable access. Reimbursement by…”
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Acquirement of Rituximab Resistance in Lymphoma Cell Lines Is Associated with Both Global CD20 Gene and Protein Down-Regulation Regulated at the Pretranscriptional and Posttranscriptional Levels by CZUCZMAN, Myron S, OLEJNICZAK, Scott, GOWDA, Aruna, KOTOWSKI, Adam, BINDER, Arvinder, KAUR, Harman, KNIGHT, Joy, STAROSTIK, Petr, DEANS, Julie, HERNANDEZ-LLIZALITURRI, Francisco J

“…Acquirement of resistance to rituximab has been observed in lymphoma patients. To define mechanisms associated with rituximab resistance, we developed various…”
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Clinical Efficacy of Lenalidomide in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia: Results of a Phase II Study by CHANAN-KHAN, Asher, MILLER, Kena C, SPANER, David, MOHR, Alice, BYRNE, Catriona, HERNANDEZ-ILIZALITURRI, Francisco, CHRYSTAL, Cynthia, STAROSTIK, Petr, CZUCZMAN, Myron S, MUSIAL, Laurie, LAWRENCE, David, PADMANABHAN, Swaminathan, TAKESHITA, Kenichi, PORTER, Carl W, GOODRICH, David W, BERNSTEIN, Zale P, WALLACE, Paul

“…Patients with relapsed or refractory chronic lymphocytic leukemia (CLL) have profound immune defects and limited treatment options. Given the dramatic activity…”
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Impact of the ABCD‐GENE Score on Clopidogrel Clinical Effectiveness after PCI: A Multi‐Site, Real‐World Investigation by Thomas, Cameron D., Franchi, Francesco, Keeley, Ellen C., Rossi, Joseph S., Winget, Marshall, David Anderson, R., Dempsey, Alyssa L., Gong, Yan, Gower, Megan N., Kerensky, Richard A., Kulick, Natasha, Malave, Jean G., McDonough, Caitrin W., Mulrenin, Ian R., Starostik, Petr, Beitelshees, Amber L., Johnson, Julie A., Stouffer, George A., Winterstein, Almut G., Angiolillo, Dominick J., Lee, Craig R., Cavallari, Larisa H.

“…The Age, Body mass index, Chronic kidney disease, Diabetes mellitus, and CYP2C19 GENEtic variants (ABCD‐GENE) score was developed to identify patients at risk…”
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Institutional profile: University of Florida Health Personalized Medicine Program by Cavallari, Larisa H, Weitzel, Kristin W, Elsey, Amanda R, Liu, Xinyue, Mosley, Scott A, Smith, Donald M, Staley, Benjamin J, Winterstein, Almut G, Mathews, Carol A, Franchi, Francesco, Rollini, Fabiana, Angiolillo, Dominick J, Starostik, Petr, Clare-Salzler, Michael J, Nelson, David R, Johnson, Julie A

“…The University of Florida (UF) Health Personalized Medicine Program launched in 2012 with genotyping for clopidogrel response at UF Health Shands Hospital. We…”
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Mixed acinar‐neuroendocrine carcinoma with amphicrine features of the pancreas: Two rare cases with diffuse co‐expression of acinar and neuroendocrine markers by Akki, Ashwin S., Liu, Xiuli, Clapp, William L., Starostik, Petr, Newsom, Kimberly J., Hughes, Steven J., Esnakula, Ashwini K.

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Pathology Informatics and Robotics Strategies for Improving Efficiency of COVID-19 Pooled Testing by Balasubramani, Balaji, Newsom, Kimberly J., Martinez, Katherine A., Starostik, Petr, Clare-Salzler, Michael, Chamala, Srikar

“…The global rise of the coronavirus disease 2019 pandemic resulted in an exponentially increasing demand for severe acute respiratory syndrome coronavirus 2…”
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Precision Antiplatelet Therapy after Percutaneous Coronary Intervention (Precision PCI) Registry – Informing optimal antiplatelet strategies by Cavallari, Larisa H., Lee, Craig R., Franchi, Francesco, Keeley, Ellen C., Rossi, Joseph S., Thomas, Cameron D., Gong, Yan, McDonough, Caitrin W., Starostik, Petr, Al Saeed, Maryam J., Been, Latonya, Kulick, Natasha, Malave, Jean, Mulrenin, Ian R., Nguyen, Anh B., Terrell, Joshua N., Tillotson, Grace, Beitelshees, Amber L., Winterstein, Almut G., Stouffer, George A., Angiolillo, Dominick J.

“…Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor (clopidogrel, prasugrel, or ticagrelor) is indicated after percutaneous coronary…”
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Automated HL7v2 LRI informatics framework for streamlining genomics-EHR data integration by Dolin, Robert H., Gupta, Rohan, Newsom, Kimberly, Heale, Bret S.E., Gothi, Shailesh, Starostik, Petr, Chamala, Srikar

“…While VCF formatted files are the lingua franca of next-generation sequencing, most EHRs do not provide native VCF support. As a result, labs often must send…”
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Clinical genotyping assay for personalized dosing of dichloroacetate by Stacpoole, Peter W., Wagner, Richard, Langaee, Taimour, Horne, Lloyd, Starostik, Petr, Lawson, Lee Ann

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A Transcriptomic Severity Metric That Predicts Clinical Outcomes in Critically Ill Surgical Sepsis Patients by Brakenridge, Scott C., Starostik, Petr, Ghita, Gabriella, Midic, Uros, Darden, Dijoia, Fenner, Brittany, Wacker, James, Efron, Philip A., Liesenfeld, Oliver, Sweeney, Timothy E., Moldawer, Lyle L.

“…OBJECTIVES: Clinically deployable methods for the rapid and accurate prediction of sepsis severity that could elicit a meaningful change in clinical practice…”
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Gastric marginal zone B-cell lymphomas of MALT type develop along 2 distinct pathogenetic pathways by Starostik, Petr, Patzner, Jochen, Greiner, Axel, Schwarz, Stephan, Kalla, Jörg, Ott, German, Müller-Hermelink, Hans Konrad

“…Low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type can transform into high-grade diffuse large B-cell lymphoma (DLBCL)…”
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