Search Results - "STANSKI, Donald"

The Titration Paradox Turns Pharmacology Upside Down by Shafer, Steven L., Stanski, Donald R.

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Radiation and PD-(L)1 treatment combinations: immune response and dose optimization via a predictive systems model by Kosinsky, Yuri, Dovedi, Simon J, Peskov, Kirill, Voronova, Veronika, Chu, Lulu, Tomkinson, Helen, Al-Huniti, Nidal, Stanski, Donald R, Helmlinger, Gabriel

“…Numerous oncology combination therapies involving modulators of the cancer immune cycle are being developed, yet quantitative simulation models predictive of…”
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Semi-Mechanistic Pharmacokinetic-Pharmacodynamic Model of Camostat Mesylate-Predicted Efficacy against SARS-CoV-2 in COVID-19 by Kosinsky, Yuri, Peskov, Kirill, Stanski, Donald R, Wetmore, Diana, Vinetz, Joseph

“…The SARS-CoV-2 coronavirus, which causes COVID-19, uses a viral surface spike protein for host cell entry and the human cell-surface transmembrane serine…”
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Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation by Snelder, Nelleke, Ploeger, Bart A, Luttringer, Olivier, Stanski, Donald R, Danhof, Meindert

“…A complicating factor in the translational pharmacology of sphingosine 1-phosphate agonists is that they exert their pharmacological effect through their…”
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Characterization of the bronchodilatory dose response to indacaterol in patients with chronic obstructive pulmonary disease using model-based approaches by Renard, Didier, Looby, Michael, Kramer, Benjamin, Lawrence, David, Morris, David, Stanski, Donald R

“…Indacaterol is a once-daily long-acting inhaled β2-agonist indicated for maintenance treatment of moderate-to-severe chronic obstructive pulmonary disease…”
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Characterization and Prediction of Cardiovascular Effects of Fingolimod and Siponimod Using a Systems Pharmacology Modeling Approach by Snelder, Nelleke, Ploeger, Bart A, Luttringer, Olivier, Rigel, Dean F, Webb, Randy L, Feldman, David, Fu, Fumin, Beil, Michael, Jin, Liang, Stanski, Donald R, Danhof, Meindert

“…Sphingosine 1-phosphate (S1P) receptor agonists are associated with cardiovascular effects in humans. This study aims to develop a systems pharmacology model…”
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Individualized treatment strategies for hyperuricemia informed by a semi‐mechanistic exposure‐response model of uric acid dynamics by Aksenov, Sergey, Peck, Carl C., Eriksson, Ulf G., Stanski, Donald R.

“…To provide insight into pharmacological treatment of hyperuricemia we developed a semi‐mechanistic, dynamical model of uric acid (UA) disposition in human. Our…”
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Input characteristics and bioavailability after administration of immediate and a new extended-release formulation of hydromorphone in healthy volunteers by DROVER, David R, ANGST, Martin S, VALLE, Marta, RAMASWAMY, Bhamini, NAIDU, Sujata, STANSKI, Donald R, VEROTTA, Davide

“…To compare the pharmacokinetics of intravenous, oral immediate-release (IR), and oral extended-release (OROS ) formulations of hydromorphone. In this…”
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Pharmacodynamics of orally administered sustained-release hydromorphone in humans by ANGST, Martin S, DROVER, David R, LÖTSCH, Jörn, RAMASWAMY, Bhamini, NAIDU, Sujata, WADA, D. Russell, STANSKI, Donald R

“…The disposition kinetics of hydromorphone generally necessitates oral administration every 4 h of the conventional immediate-release tablet to provide…”
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Innovative approaches to clinical development and trial design by Orloff, John J, Stanski, Donald

“…Pharmaceutical innovation is increasingly risky, costly and at times inefficient, which has led to a decline in industry productivity. Despite the increased…”
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Fostering Culture and Optimizing Organizational Structure for Implementing Model-Based Drug Development by Zhang, Liping, Allerheiligen, Sandra R., Lalonde, Richard L., Stanski, Donald R., Pfister, Marc

“…Model‐based drug development (MBDD) is a promising approach to improve decision making in drug development. The pharmaceutical industry has made substantial…”
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Pharmacokinetic/Pharmacodynamic Modeling in Drug Research and Development by Derendorf, Hartmut, Lesko, Lawrence J., Chaikin, Philip, Colburn, Wayne A., Lee, Peter, Miller, Raymond, Powell, Robert, Rhodes, Gerald, Stanski, Donald, Venitz, Jürgen

“…The two domains in clinical pharmacology dealing with optimizing dosing recommendations are pharmacokinetics and pharmacodynamics. However, the usefulness of…”
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Communicating With the FDA: The "Third Rail" of a New Model for Drug Development by Stanski, Donald R., Orloff, John J.

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Lumbar Epidural morphine in humans and supraspinal analgesia to experimental heat pain by ANGST, M. S, RAMASWAMY, B, RILEY, E. T, STANSKI, D. R

“…Epidural administration of morphine is a common analgesic technique to manage pain. Morphine spreads from the epidural space to the cerebrospinal fluid and…”
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Application of physiologic models to predict the influence of changes in body composition and blood flows on the pharmacokinetics of fentanyl and alfentanil in patients by BJÖRKMAN, S, WADA, D. R, STANSKI, D. R

“…The influence of changes in the physiologic state of a patient on the disposition of fentanyl and alfentanil is poorly understood. The aims of this study were…”
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Computer simulation of the effects of alterations in blood flows and body composition on thiopental pharmacokinetics in humans by WADA, D. R, BJÖRKMAN, S, EBLING, W. F, HARASHIMA, H, HARAPAT, S. R, STANSKI, D. R

“…Understanding the influence of physiological variables on thiopental pharmacokinetics would enhance the scientific basis for the clinical usage of this…”
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Inadequate anaesthesia in lethal injection for execution by Groner, Jonathan I

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Enriched analgesic efficacy studies: An assessment by clinical trial simulation by Lemmens, Hendrikus J.M., Wada, D. Russell, Munera, Catherine, Eltahtawy, Ahmed, Stanski, Donald R.

“…Enrichment strategies which select subjects who appear to respond to the drug have been used in drug studies to demonstrate clinical efficacy. We have used…”
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Getting the dose right : Report from the tenth european federation of pharmaceutical sciences (EUFEPS) conference on optimizing drug development by STANSKI, Donald R, ROWLAND, Malcolm, SHEINER, Lewis B

“…This report highlights the main points emerging from a meeting sponsored on "Getting the Dose Right" in clinical development, jointly sponsored by the European…”
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A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect by Billard, Valérie, Gambus, Pedro L., Chamoun, Nassib, Stanski, Donald R., Shafer, Steven L.

“…Background The effects of anesthetic drugs on electroencephalograms (EEG) have been studied to develop the EEG as a measure of anesthetic depth. Bispectral…”
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