Search Results - "STANSFIELD, Ian G"

Studies towards the identification of a new generation of atypical antipsychotic agents by Garzya, Vincenzo, Forbes, Ian T., Gribble, Andrew D., Hadley, Mike S., Lightfoot, Andrew P., Payne, Andrew H., Smith, Alexander B., Douglas, Sara E., Cooper, David G., Stansfield, Ian G., Meeson, Malcom, Dodds, Emma E., Jones, Declan N.C., Wood, Martyn, Reavill, Charlie, Scorer, Carol A., Worby, Angela, Riley, Graham, Eddershaw, Peter, Ioannou, Chris, Donati, Daniele, Hagan, Jim J., Ratti, Emiliangelo A.

“…The SAR study around compound ( 1), led to the identification of sulfonamide ( 25), a molecule combining dopamine D 2/D 3 receptor antagonism with serotonin…”
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The identification of clinical candidate SB-480848 : A potent inhibitor of lipoprotein-associated phospholipase A2 by BLACKIE, Josie A, BLOOMER, Jackie C, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, BROWN, Murray J. B, CHENG, Hung-Yuan, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H

“…Modification of the pyrimidone 5-substituent in clinical candidate SB-435495 has given a series of inhibitors of recombinant lipoprotein-associated…”
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The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure by HOLMES, Ian P, BLUNT, Richard J, HOWES, Claire M, MICHELI, Fabrizio, DI FABIO, Romano, DONATI, Daniele, TERRENI, Silvia, HAMPRECHT, Dieter, ARISTA, Luca, WORBY, Angela, WATSON, Steve P, LORTHIOIR, Olivier E, BLOWERS, Stephen M, GRIBBLE, Andy, PAYNE, Andrew H, STANSFIELD, Ian G, WOOD, Martyn, WOOLLARD, Patrick M, REAVILL, Charlie

“…The identification of a highly selective D(2) partial agonist, D(3) antagonist tool molecule which demonstrates high levels of brain exposure and selectivity…”
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The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-associated phospholipase A2 for evaluation in man by BLACKIE, Josie A, BLOOMER, Jackie C, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, BROWN, Murray J. B, CHENG, Hung-Yuan, ELLIOTT, Richard L, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann

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Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones by BOYD, Helen F, FELL, Stephen C. M, STANSFIELD, Ian G, STANWAY, Steven J, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A

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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2 by BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L

“…From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human…”
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1-(Arylpiperazinylamidoalkyl)-pyrimidones : Orally active inhibitors of lipoprotein-associated phospholipase A2 by BLOOMER, Jackie C, BOYD, Helen F, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A

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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2 by BOYD, Helen F, HAMMOND, Beverley, STANSFIELD, Ian G, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, SMITH, Stephen A

“…Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase…”
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The identification of a selective dopamine D 2 partial agonist, D 3 antagonist displaying high levels of brain exposure by Holmes, Ian P., Blunt, Richard J., Lorthioir, Olivier E., Blowers, Stephen M., Gribble, Andy, Payne, Andrew H., Stansfield, Ian G., Wood, Martyn, Woollard, Patrick M., Reavill, Charlie, Howes, Claire M., Micheli, Fabrizio, Fabio, Romano Di, Donati, Daniele, Terreni, Silvia, Hamprecht, Dieter, Arista, Luca, Worby, Angela, Watson, Steve P.

“…The identification of a hitherto unprecedented pharmacology in a compound ( 3) displaying highly selective DA D2 partial agonism and DA D3 antagonism, but…”
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The identification of a selective dopamine D sub(2) partial agonist, D sub(3) antagonist displaying high levels of brain exposure by Holmes, Ian P, Blunt, Richard J, Lorthioir, Olivier E, Blowers, Stephen M, Gribble, Andy, Payne, Andrew H, Stansfield, Ian G, Wood, Martyn, Woollard, Patrick M, Reavill, Charlie, Howes, Claire M, Micheli, Fabrizio, Di Fabio, Romano, Donati, Daniele, Terreni, Silvia, Hamprecht, Dieter, Arista, Luca, Worby, Angela, Watson, Steve P

“…The identification of a highly selective D sub(2) partial agonist, D sub(3) antagonist tool molecule which demonstrates high levels of brain exposure and…”
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones by Boyd, Helen F, Fell, Stephen C M, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Macphee, Colin H, Milliner, Kevin J, Pinto, Ivan L, Rawlings, D Anthony, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Theobald, Colin J, Whittaker, Caroline M

“…A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A(2) with…”
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Potent, orally active inhibitors of lipoprotein-associated phospholipase A 2: 1-(biphenylmethylamidoalkyl)-pyrimidones by Boyd, Helen F., Fell, Stephen C.M., Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Macphee, Colin H., Milliner, Kevin J., Pinto, Ivan L., Rawlings, D.Anthony, Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Theobald, Colin J., Whittaker, Caroline M.

“…A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A 2 with…”
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The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A 2 by Blackie, Josie A., Bloomer, Jackie C., Brown, Murray J.B., Cheng, Hung-Yuan, Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J.

“…Modification of the pyrimidone 5-substituent in clinical candidate SB-435495 has given a series of inhibitors of recombinant lipoprotein-associated…”
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The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man by Blackie, Josie A, Bloomer, Jackie C, Brown, Murray J B, Cheng, Hung-Yuan, Elliott, Richard L, Hammond, Beverley, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Lewis, V Ann, Macphee, Colin H, Milliner, Kevin J, Moores, Kitty E, Pinto, Ivan L, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Taylor, Maxine A, Theobald, Colin J, Whittaker, Caroline M

“…The introduction of a functionalised amido substituent into a series of 1-(biphenylmethylacetamido)-pyrimidones has given a series of inhibitors of recombinant…”
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The discovery of SB-435495 by Blackie, Josie A., Bloomer, Jackie C., Brown, Murray J.B., Cheng, Hung-Yuan, Elliott, Richard L., Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J., Whittaker, Caroline M.

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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A 2 by Boyd, Helen F., Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Theobald, Colin J., Whittaker, Caroline M.

“…Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase…”
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The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-Associated phospholipase A 2 for evaluation in man by Blackie, Josie A., Bloomer, Jackie C., Brown, Murray J.B., Cheng, Hung-Yuan, Elliott, Richard L., Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J., Whittaker, Caroline M.

“…The introduction of a functionalised amido substituent into a series of 1-(biphenylmethylacetamido)-pyrimidones has given a series of inhibitors of recombinant…”
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2-(alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2 by BOYD, H. F, FLYNN, S. T, SMITH, S. A, STANSFIELD, I. G, TEW, D. G, THEOBALD, C. J, HICKEY, D. M. B, IFE, R. J, JONES, M, LEACH, C. A, MACPHEE, C. H, MILLINER, K. J, RAWLINGS, D. A, SLINGSBY, B. P

“…Starting from two weakly active hits from high throughput screening, a novel series of 2-(alkylthio)-pyrimidin-4-ones with high potency and selectivity for…”
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1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A 2 by Bloomer, Jackie C., Boyd, Helen F., Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Macphee, Colin H., Milliner, Kevin J., Pinto, Ivan L., Rawlings, D.Anthony, Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J., Whittaker, Caroline M.

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2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A 2 by Boyd, Helen F., Flynn, Sean T., Hickey, Deirdre M.B., Ife, Robert J., Jones, Martin, Leach, Colin A., Macphee, Colin H., Milliner, Kevin J., Rawlings, D.Anthony, Slingsby, Brian P., Smith, Stephen A., Stansfield, Ian G., Tew, David G., Theobald, Colin J.

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