Search Results - "STANLEY, Sarah A"

Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles by Stanley, Sarah A, Sauer, Jeremy, Kane, Ravi S, Dordick, Jonathan S, Friedman, Jeffrey M

“…Development and validation of a genetically encoded system in which gene expression is regulated remotely and noninvasively by either low-frequency radio waves…”
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Radio-Wave Heating of Iron Oxide Nanoparticles Can Regulate Plasma Glucose in Mice by Stanley, Sarah A., Gagner, Jennifer E., Damanpour, Shadi, Yoshida, Mitsukuni, Dordick, Jonathan S., Friedman, Jeffrey M.

“…Medical applications of nanotechnology typically focus on drug delivery and biosensors. Here, we combine nanotechnology and bioengineering to demonstrate that…”
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Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism by Stanley, Sarah A., Kelly, Leah, Latcha, Kaamashri N., Schmidt, Sarah F., Yu, Xiaofei, Nectow, Alexander R., Sauer, Jeremy, Dyke, Jonathan P., Dordick, Jonathan S., Friedman, Jeffrey M.

“…Activation of glucose-sensing neurons in the ventromedial hypothalamic nucleus using radio waves or magnetic fields remotely and non-invasively in vivo…”
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IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α by Van Dis, Erik, Fox, Douglas M, Morrison, Huntly M, Fines, Daniel M, Babirye, Janet Peace, McCann, Lily H, Rawal, Sagar, Cox, Jeffery S, Stanley, Sarah A

“…The prevailing model of protective immunity to tuberculosis is that CD4 T cells produce the cytokine IFN-γ to activate bactericidal mechanisms in infected…”
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Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth by Stanley, Sarah A, Barczak, Amy K, Silvis, Melanie R, Luo, Samantha S, Sogi, Kimberly, Vokes, Martha, Bray, Mark-Anthony, Carpenter, Anne E, Moore, Christopher B, Siddiqi, Noman, Rubin, Eric J, Hung, Deborah T

“…Mycobacterium tuberculosis remains a significant threat to global health. Macrophages are the host cell for M. tuberculosis infection, and although bacteria…”
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Identification of Novel Inhibitors of M. tuberculosis Growth Using Whole Cell Based High-Throughput Screening by Stanley, Sarah A, Grant, Sarah Schmidt, Kawate, Tomohiko, Iwase, Noriaki, Shimizu, Motohisa, Wivagg, Carl, Silvis, Melanie, Kazyanskaya, Edward, Aquadro, John, Golas, Aaron, Fitzgerald, Michael, Dai, Huanqin, Zhang, Lixin, Hung, Deborah T

“…Despite the urgent need for new antitubercular drugs, few are on the horizon. To combat the problem of emerging drug resistance, structurally unique chemical…”
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Open-source RNA extraction and RT-qPCR methods for SARS-CoV-2 detection by Graham, Thomas G W, Dugast-Darzacq, Claire, Dailey, Gina M, Nguyenla, Xammy H, Van Dis, Erik, Esbin, Meagan N, Abidi, Abrar, Stanley, Sarah A, Darzacq, Xavier, Tjian, Robert

“…Re-opening of communities in the midst of the ongoing COVID-19 pandemic has ignited new waves of infections in many places around the world. Mitigating the…”
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The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors by Darwin, K Heran, Stanley, Sarah A

“…There are many reactive intermediates found in metabolic pathways. Could these potentially toxic molecules be exploited for an organism's benefit? We propose…”
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STING-Activating Adjuvants Elicit a Th17 Immune Response and Protect against Mycobacterium tuberculosis Infection by Van Dis, Erik, Sogi, Kimberly M., Rae, Chris S., Sivick, Kelsey E., Surh, Natalie H., Leong, Meredith L., Kanne, David B., Metchette, Ken, Leong, Justin J., Bruml, Jacob R., Chen, Vivian, Heydari, Kartoosh, Cadieux, Nathalie, Evans, Tom, McWhirter, Sarah M., Dubensky, Thomas W., Portnoy, Daniel A., Stanley, Sarah A.

“…There are a limited number of adjuvants that elicit effective cell-based immunity required for protection against intracellular bacterial pathogens. Here, we…”
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Mammary duct luminal epithelium controls adipocyte thermogenic programme by Patel, Sanil, Sparman, Njeri Z. R., Arneson, Douglas, Alvarsson, Alexandra, Santos, Luís C., Duesman, Samuel J., Centonze, Alessia, Hathaway, Ephraim, Ahn, In Sook, Diamante, Graciel, Cely, Ingrid, Cho, Chung Hwan, Talari, Noble Kumar, Rajbhandari, Abha K., Goedeke, Leigh, Wang, Peng, Butte, Atul J., Blanpain, Cédric, Chella Krishnan, Karthickeyan, Lusis, Aldons J., Stanley, Sarah A., Yang, Xia, Rajbhandari, Prashant

“…Sympathetic activation during cold exposure increases adipocyte thermogenesis via the expression of mitochondrial protein uncoupling protein 1 (UCP1) 1 . The…”
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Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitro by Zeng, Leiping, Liu, Yanxia, Nguyenla, Xammy Huu, Abbott, Timothy R., Han, Mengting, Zhu, Yanyu, Chemparathy, Augustine, Lin, Xueqiu, Chen, Xinyi, Wang, Haifeng, Rane, Draven A., Spatz, Jordan M., Jain, Saket, Rustagi, Arjun, Pinsky, Benjamin, Zepeda, Adrianna E., Kadina, Anastasia P., Walker, John A., Holden, Kevin, Temperton, Nigel, Cochran, Jennifer R., Barron, Annelise E., Connolly, Michael D., Blish, Catherine A., Lewis, David B., Stanley, Sarah A., La Russa, Marie F., Qi, Lei S.

“…A major challenge in coronavirus vaccination and treatment is to counteract rapid viral evolution and mutations. Here we demonstrate that CRISPR-Cas13d offers…”
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Practical considerations for Ultraviolet-C radiation mediated decontamination of N95 respirator against SARS-CoV-2 virus by Golovkine, Guillaume R, Roberts, Allison W, Cooper, Chase, Riano, Sebastian, DiCiccio, Angela M, Worthington, Daniel L, Clarkson, Jeffrey P, Krames, Michael, Zhang, Jianping, Gao, Ying, Zhou, Ling, Biering, Scott B, Stanley, Sarah A

“…Decontaminating N95 respirators for reuse could mitigate shortages during the COVID-19 pandemic. Although the United States Center for Disease Control has…”
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Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure by Katz, Liora S., Brill, Gabriel, Zhang, Pili, Kumar, Anil, Baumel-Alterzon, Sharon, Honig, Lee B., Gómez-Banoy, Nicolás, Karakose, Esra, Tanase, Marius, Doridot, Ludivine, Alvarsson, Alexandra, Davenport, Bennett, Wang, Peng, Lambertini, Luca, Stanley, Sarah A., Homann, Dirk, Stewart, Andrew F., Lo, James C., Herman, Mark A., Garcia-Ocaña, Adolfo, Scott, Donald K.

“…Preservation and expansion of β-cell mass is a therapeutic goal for diabetes. Here we show that the hyperactive isoform of carbohydrate response-element…”
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Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32 by Stanley, Sarah A., Kawate, Tomohiko, Iwase, Noriaki, Shimizu, Motohisa, Clatworthy, Anne E., Kazyanskaya, Edward, Sacchettini, James C., Ioerger, Thomas R., Siddiqi, Noman A., Minami, Shoko, Aquadro, John A., Grant, Sarah Schmidt, Rubin, Eric J., Hung, Deborah T.

“…Infection with the bacterial pathogen Mycobacterium tuberculosis imposes an enormous burden on global public health. New antibiotics are urgently needed to…”
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Mapping of UV-C dose and SARS-CoV-2 viral inactivation across N95 respirators during decontamination by Geldert, Alisha, Su, Alison, Roberts, Allison W., Golovkine, Guillaume, Grist, Samantha M., Stanley, Sarah A., Herr, Amy E.

“…During public health crises like the COVID-19 pandemic, ultraviolet-C (UV-C) decontamination of N95 respirators for emergency reuse has been implemented to…”
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A nanocompartment system contributes to defense against oxidative stress in Mycobacterium tuberculosis by Lien, Katie A, Dinshaw, Kayla, Nichols, Robert J, Cassidy-Amstutz, Caleb, Knight, Matthew, Singh, Rahul, Eltis, Lindsay D, Savage, David F, Stanley, Sarah A

“…Encapsulin nanocompartments are an emerging class of prokaryotic protein-based organelle consisting of an encapsulin protein shell that encloses a protein…”
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Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens by Morrison, Huntly M, Craft, Julia, Rivera-Lugo, Rafael, Johnson, Jeffery R, Golovkine, Guillaume R, Bell, Samantha L, Dodd, Claire E, Van Dis, Erik, Beatty, Wandy L, Margolis, Shally R, Repasy, Teresa, Shaker, Isaac, Lee, Angus Y, Vance, Russell E, Stanley, Sarah A, Watson, Robert O, Krogan, Nevan J, Portnoy, Daniel A, Penn, Bennett H, Cox, Jeffery S

“…Macrophages employ an array of pattern recognition receptors to detect and eliminate intracellular pathogens that access the cytosol. The cytosolic…”
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Acute Infection and Macrophage Subversion by Mycobacterium tuberculosis Require a Specialized Secretion System by Stanley, Sarah A., Raghavan, Sridharan, Hwang, William W., Cox, Jeffery S.

“…Although many bacterial pathogens use specialized secretion systems for virulence, no such systems have been described for Mycobacterium tuberculosis, a major…”
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Author Correction: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure by Katz, Liora S., Brill, Gabriel, Zhang, Pili, Kumar, Anil, Baumel-Alterzon, Sharon, Honig, Lee B., Gómez-Banoy, Nicolás, Karakose, Esra, Tanase, Marius, Doridot, Ludivine, Alvarsson, Alexandra, Davenport, Bennett, Wang, Peng, Lambertini, Luca, Stanley, Sarah A., Homann, Dirk, Stewart, Andrew F., Lo, James C., Herman, Mark A., Garcia-Ocaña, Adolfo, Scott, Donald K.

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RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities by Barczak, Amy K, Gomez, James E, Kaufmann, Benjamin B, Hinson, Ella R, Cosimi, Lisa, Borowsky, Mark L, Onderdonk, Andrew B, Stanley, Sarah A, Kaur, Devinder, Bryant, Kevin F, Knipe, David M, Sloutsky, Alexander, Hung, Deborah T

“…With rising rates of drug-resistant infections, there is a need for diagnostic methods that rapidly can detect the presence of pathogens and reveal their…”
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