Search Results - "STAMLER, Jonathan S"

The SNO-proteome: causation and classifications by Seth, Divya, Stamler, Jonathan S

“…Cell signaling is a complex and highly regulated process. Post-translational modifications of proteins serve to sense and transduce cellular signals in a…”
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Regulated Protein Denitrosylation by Cytosolic and Mitochondrial Thioredoxins by Benhar, Moran, Forrester, Michael T, Hess, Douglas T, Stamler, Jonathan S

“…Nitric oxide acts substantially in cellular signal transduction through stimulus-coupled S-nitrosylation of cysteine residues. The mechanisms that might…”
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Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy by Liao, Xudong, Shen, Yuyan, Zhang, Rongli, Sugi, Keiki, Vasudevan, Neelakantan T., Alaiti, M. Amer, Sweet, David R., Zhou, Lin, Qing, Yulan, Gerson, Stanton L., Fu, Chen, Wynshaw-Boris, Anthony, Hu, Rui, Schwartz, Martin A., Fujioka, Hisashi, Richardson, Brian, Cameron, Mark J., Hayashi, Hiroki, Stamler, Jonathan S., Jain, Mukesh K.

“…Nonischemic cardiomyopathy (NICM) resulting from long-standing hypertension, valvular disease, and genetic mutations is a major cause of heart failure…”
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Activation of hepatic acetyl-CoA carboxylase by S-nitrosylation in response to diet by Venetos, Nicholas M., Stomberski, Colin T., Qian, Zhaoxia, Premont, Richard T., Stamler, Jonathan S.

“…Nitric oxide (NO), produced primarily by nitric oxide synthase enzymes, is known to influence energy metabolism by stimulating fat uptake and oxidation. The…”
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Site-specific analysis of protein S-acylation by resin-assisted capture[S] by Forrester, Michael T., Hess, Douglas T., Thompson, J. Will, Hultman, Rainbo, Moseley, M. Arthur, Stamler, Jonathan S., Casey, Patrick J.

“…Protein S-acylation is a major posttranslational modification whereby a cysteine thiol is converted to a thioester. A prototype is S-palmitoylation (fatty…”
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Hemoglobin βCys93 is essential for cardiovascular function and integrated response to hypoxia by Zhang, Rongli, Hess, Douglas T., Qian, Zhaoxia, Hausladen, Alfred, Fonseca, Fabio, Chaube, Ruchi, Reynolds, James D., Stamler, Jonathan S.

“…Oxygen delivery by Hb is essential for vertebrate life. Three amino acids in Hb are strictly conserved in all mammals and birds, but only two of those, a His…”
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Redox activation of ATM enhances GSNOR translation to sustain mitophagy and tolerance to oxidative stress by Cirotti, Claudia, Rizza, Salvatore, Giglio, Paola, Poerio, Noemi, Allega, Maria Francesca, Claps, Giuseppina, Pecorari, Chiara, Lee, Ji-Hoon, Benassi, Barbara, Barilà, Daniela, Robert, Caroline, Stamler, Jonathan S, Cecconi, Francesco, Fraziano, Maurizio, Paull, Tanya T, Filomeni, Giuseppe

“…The denitrosylase S -nitrosoglutathione reductase (GSNOR) has been suggested to sustain mitochondrial removal by autophagy (mitophagy), functionally linking S…”
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S-nitrosohemoglobin deficiency: A mechanism for loss of physiological activity in banked blood by Reynolds, James D, Ahearn, Gregory S, Angelo, Michael, Zhang, Jian, Cobb, Fred, Stamler, Jonathan S

“…RBCs distribute oxygen to tissues, but, paradoxically, blood transfusion does not always improve oxygen delivery and is associated with ischemic events. We…”
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Glioma Stem Cell Proliferation and Tumor Growth Are Promoted by Nitric Oxide Synthase-2 by Eyler, Christine E., Wu, Qiulian, Yan, Kenneth, MacSwords, Jennifer M., Chandler-Militello, Devin, Misuraca, Katherine L., Lathia, Justin D., Forrester, Michael T., Lee, Jeongwu, Stamler, Jonathan S., Goldman, Steven A., Bredel, Markus, McLendon, Roger E., Sloan, Andrew E., Hjelmeland, Anita B., Rich, Jeremy N.

“…Malignant gliomas are aggressive brain tumors with limited therapeutic options, and improvements in treatment require a deeper molecular understanding of this…”
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Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis by Liao, Xudong, Zhang, Rongli, Lu, Yuan, Prosdocimo, Domenick A, Sangwung, Panjamaporn, Zhang, Lilei, Zhou, Guangjin, Anand, Puneet, Lai, Ling, Leone, Teresa C, Fujioka, Hisashi, Ye, Fang, Rosca, Mariana G, Hoppel, Charles L, Schulze, P Christian, Abel, E Dale, Stamler, Jonathan S, Kelly, Daniel P, Jain, Mukesh K

“…Mitochondrial homeostasis is critical for tissue health, and mitochondrial dysfunction contributes to numerous diseases, including heart failure. Here, we have…”
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Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation by Anand, Puneet, Hausladen, Alfred, Wang, Ya-Juan, Zhang, Guo-Fang, Stomberski, Colin, Brunengraber, Henri, Hess, Douglas T., Stamler, Jonathan S.

“…Significance Coenzyme A (CoA) is a small-molecular-weight thiol that plays a central role in cellular metabolism. We have discovered a novel, phylogenetically…”
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An S-Nitrosothiol (SNO) Synthase Function of Hemoglobin That Utilizes Nitrite as a Substrate by Angelo, Michael, Singel, David J., Stamler, Jonathan S.

“…Red blood cells (RBCs) act as O₂-responsive transducers of vasodilator and vasoconstrictor activity in lungs and tissues by regulating the availability of…”
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Identification of the Enzymatic Mechanism of Nitroglycerin Bioactivation by Chen, Zhiqiang, Zhang, Jian, Stamler, Jonathan S.

“…Nitroglycerin (glyceryl trinitrate, GTN), originally manufactured by Alfred Nobel, has been used to treat angina and heart failure for over 130 years. However,…”
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Physiology of Nitric Oxide in Skeletal Muscle by Stamler, Jonathan S, Meissner, Gerhard

“…Howard Hughes Medical Institute, Department of Medicine, Divisions of Pulmonary and Cardiology and Department of Biochemistry, Duke University Medical Center,…”
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Assessment and Application of the Biotin Switch Technique for Examining Protein S-Nitrosylation under Conditions of Pharmacologically Induced Oxidative Stress by Forrester, Michael T., Foster, Matthew W., Stamler, Jonathan S.

“…Protein S-nitrosylation has emerged as a principal mechanism by which nitric oxide exerts biological effects. Among methods for studying protein…”
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Myeloid Krüppel-Like Factor 4 Deficiency Augments Atherogenesis in ApoE−/− Mice—Brief Report by Sharma, Nikunj, Lu, Yuan, Zhou, Guangjin, Liao, Xudong, Kapil, Parul, Anand, Puneet, Mahabeleshwar, Ganapati H, Stamler, Jonathan S, Jain, Mukesh K

“…OBJECTIVE—To investigate the role of Krüppel-like factor 4 (KLF4), an essential transcriptional regulator of macrophage polarization (M1/M2), in the…”
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protein microarray-based analysis of S-nitrosylation by Foster, Matthew W, Forrester, Michael T, Stamler, Jonathan S

“…The ubiquitous cellular influence of nitric oxide (NO) is exerted substantially through protein S-nitrosylation. Whereas NO is highly promiscuous,…”
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Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4 by Sun, Qi-An, Hess, Douglas T, Nogueira, Leonardo, Yong, Sandro, Bowles, Dawn E, Eu, Jerry, Laurita, Kenneth R, Meissner, Gerhard, Stamler, Jonathan S

“…Physiological sensing of O2 tension (partial O2 pressure, pO2) plays an important role in some mammalian cellular systems, but striated muscle generally is not…”
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Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870) by Sun, Qi-An, Hess, Douglas T., Wang, Benlian, Miyagi, Masaru, Stamler, Jonathan S.

“…Specific inhibitors of the production of reactive oxygen species (ROS) by the NADPH oxidases (Nox's) are potentially important therapeutic agents in the wide…”
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Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function by Beigi, Farideh, Gonzalez, Daniel R, Minhas, Khalid M, Sun, Qi-An, Foster, Matthew W, Khan, Shakil A, Treuer, Adriana V, Dulce, Raul A, Harrison, Robert W, Saraiva, Roberto M, Premer, Courtney, Schulman, Ivonne Hernandez, Stamler, Jonathan S, Hare, Joshua M

“…Although protein S-nitrosylation is increasingly recognized as mediating nitric oxide (NO) signaling, roles for protein denitrosylation in physiology remain…”
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