Search Results - "STAMBROOK, Peter J"

Next-generation sequencing technologies: breaking the sound barrier of human genetics by Bahassi, El Mustapha, Stambrook, Peter J

“…Demand for new technologies that deliver fast, inexpensive and accurate genome information has never been greater. This challenge has catalysed the rapid…”
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Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration by Huang, Wei, Feng, Yuliang, Liang, Jialiang, Yu, Hao, Wang, Cheng, Wang, Boyu, Wang, Mingyang, Jiang, Lin, Meng, Wei, Cai, Wenfeng, Medvedovic, Mario, Chen, Jenny, Paul, Christian, Davidson, W. Sean, Sadayappan, Sakthivel, Stambrook, Peter J., Yu, Xi-Yong, Wang, Yigang

“…The goal of replenishing the cardiomyocyte (CM) population using regenerative therapies following myocardial infarction (MI) is hampered by the limited…”
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Cancer Immunotherapy: Whence and Whither by Stambrook, Peter J, Maher, John, Farzaneh, Farzin

“…The current concepts and practice of cancer immunotherapy evolved from classical experiments that distinguished "self" from "non-self" and the finding that…”
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Restoration of an Absent G1 Arrest and Protection from Apoptosis in Embryonic Stem Cells after Ionizing Radiation by Hong, Yiling, Stambrook, Peter J., Dawid, Igor B.

“…Response to DNA damage and cell-cycle regulation differ markedly between embryonic stem (ES) cells and somatic cells. ES cells require exquisitely sensitive…”
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Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer by Fu, Jie, Ling, Jianhua, Li, Ching-Fei, Tsai, Chi-Lin, Yin, Wenjuan, Hou, Junwei, Chen, Ping, Cao, Yu, Kang, Ya’an, Sun, Yichen, Xia, Xianghou, Jiang, Zhou, Furukawa, Kenei, Lu, Yu, Wu, Min, Huang, Qian, Yao, Jun, Hawke, David H., Pan, Bih-Fang, Zhao, Jun, Huang, Jiaxing, Wang, Huamin, Bahassi, E. I. Mustapha, Stambrook, Peter J., Huang, Peng, Fleming, Jason B., Maitra, Anirban, Tainer, John A., Hung, Mien-Chie, Lin, Chunru, Chiao, Paul J.

“…Pancreatic ductal adenocarcinoma (PDAC) develops through step-wise genetic and molecular alterations including Kras mutation and inactivation of various…”
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Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution by Mamrosh, Jennifer L, Lee, Jae Man, Wagner, Martin, Stambrook, Peter J, Whitby, Richard J, Sifers, Richard N, Wu, San-Pin, Tsai, Ming-Jer, Demayo, Francesco J, Moore, David D

“…Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by…”
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Functional and molecular interactions between ERK and CHK2 in diffuse large B-cell lymphoma by Dai, Bojie, Zhao, X. Frank, Mazan-Mamczarz, Krystyna, Hagner, Patrick, Corl, Sharon, Bahassi, El Mustapha, Lu, Song, Stambrook, Peter J., Shapiro, Paul, Gartenhaus, Ronald B.

“…Distinct oncogenic signalling cascades have been associated with non-Hodgkin lymphoma. ERK1/2 signalling elicits both transcriptional and post-transcriptional…”
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Embryonic Stem Cells and Somatic Cells Differ in Mutation Frequency and Type by Cervantes, Rachel B., Stringer, James R., Shao, Changshun, Tischfield, Jay A., Stambrook, Peter J.

“…Pluripotent embryonic stem (ES) cells have been used to produce genetically modified mice as experimental models of human genetic diseases. Increasingly, human…”
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Genomic signatures of near-extinction and rebirth of the crested ibis and other endangered bird species by Li, Shengbin, Li, Bo, Cheng, Cheng, Xiong, Zijun, Liu, Qingbo, Lai, Jianghua, Carey, Hannah V, Zhang, Qiong, Zheng, Haibo, Wei, Shuguang, Zhang, Hongbo, Chang, Liao, Liu, Shiping, Zhang, Shanxin, Yu, Bing, Zeng, Xiaofan, Hou, Yong, Nie, Wenhui, Guo, Youmin, Chen, Teng, Han, Jiuqiang, Wang, Jian, Wang, Jun, Chen, Chen, Liu, Jiankang, Stambrook, Peter J, Xu, Ming, Zhang, Guojie, Gilbert, M Thomas P, Yang, Huanming, Jarvis, Erich D, Yu, Jun, Yan, Jianqun

“…Nearly one-quarter of all avian species is either threatened or nearly threatened. Of these, 73 species are currently being rescued from going extinct in…”
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Mice with the CHEK21100delC SNP are predisposed to cancer with a strong gender bias by Bahassi, El Mustapha, Robbins, Susan B, Yin, Moying, Boivin, Gregory P, Kuiper, Raoul, van Steeg, Harry, Stambrook, Peter J

“…The CHEK2 kinase (Chk2 in mouse) is a member of a DNA damage response pathway that regulates cell cycle arrest at cell cycle checkpoints and facilitates the…”
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The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels by Tichy, Elisia D, Pillai, Resmi, Deng, Li, Tischfield, Jay A, Hexley, Philip, Babcock, George F, Stambrook, Peter J

“…DNA double-strand breaks (DSBs) in embryonic stem (ES) cells are repaired primarily by homologous recombination (HR). The mechanism by which HR is regulated in…”
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Centrosome hyperamplification in human cancer : chromosome instability induced by p53 mutation and/or Mdm2 overexpression by CARROLL, P. E, OKUDA, M, HORN, H. F, BIDDINGER, P, STAMBROOK, P. J, GLEICH, L. L, LI, Y.-Q, TARAPORE, P, FUKASAWA, K

“…We have previously reported that loss of p53 tumor suppressor protein results in centrosome hyperamplification, which leads to aberrant mitosis and chromosome…”
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Preservation of genomic integrity in mouse embryonic stem cells by Stambrook, Peter J, Tichy, Elisia D

“…Embryonic stem (ES) cells and germ cells have the potential to give rise to an entire organism. A common requirement is that both must have very robust…”
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DNA repair in murine embryonic stem cells and differentiated cells by Tichy, Elisia D., Stambrook, Peter J.

“…Embryonic stem (ES) cells are rapidly proliferating, self-renewing cells that have the capacity to differentiate into all three germ layers to form the embryo…”
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Treatment of osteoporosis with a modified zeolite shows beneficial effects in an osteoporotic rat model and a human clinical trial by Kraljević Pavelić, Sandra, Micek, Vedran, Bobinac, Dragica, Bazdulj, Edo, Gianoncelli, Alessandra, Krpan, Dalibor, Žuvić, Marta, Eisenwagen, Sandra, Stambrook, Peter J, Pavelić, Krešimir

“…The severity of osteoporosis in humans manifests in its high incidence and by its complications that diminish quality of life. A societal consequence of…”
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BRUCE preserves genomic stability in the male germline of mice by Che, Lixiao, Alavattam, Kris G., Stambrook, Peter J., Namekawa, Satoshi H., Du, Chunying

“…BRUCE is a DNA damage response protein that promotes the activation of ATM and ATR for homologous recombination (HR) repair in somatic cells, making BRUCE a…”
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Mouse embryonic stem cells, but not somatic cells, predominantly use homologous recombination to repair double-strand DNA breaks by Tichy, Elisia D, Pillai, Resmi, Deng, Li, Liang, Li, Tischfield, Jay, Schwemberger, Sandy J, Babcock, George F, Stambrook, Peter J

“…Embryonic stem (ES) cells give rise to all cell types of an organism. Since mutations at this embryonic stage would affect all cells and be detrimental to the…”
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A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis by Bahassi, El Mustapha, Yin, Moying, Robbins, Susan B, Li, Ya-Qin, Conrady, Deborah G, Yuan, Zhenyu, Kovall, Rhett A, Herr, Andrew B, Stambrook, Peter J

“…Failure to regulate the levels of Cdc25A phosphatase during the cell cycle or during a checkpoint response causes bypass of DNA damage and replication…”
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Acetylation and deacetylation of Cdc25A constitutes a novel mechanism for modulating Cdc25A functions with implications for cancer by Lozada, Enerlyn M, Andrysik, Zdenek, Yin, Moying, Redilla, Nicholas, Rice, Kathryn, Stambrook, Peter J

“…The dual specificity phosphatase Cdc25A is a key regulator of the cell cycle that promotes cell cycle progression by dephosphorylating and activating…”
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X-rays induce distinct patterns of somatic mutation in fetal versus adult hematopoietic cells by Liang, Li, Deng, Li, Mendonca, Marc S., Chen, Yanping, Zheng, Betty, Stambrook, Peter J., Shao, Changshun, Tischfield, Jay A.

“…There are a variety of mechanisms and pathways whereby cells safeguard their genomes in the face of environmental insults that damage DNA. Whether each of…”
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