Search Results - "STALLINGS, Raymond"

Differential patterns of microRNA expression in neuroblastoma are correlated with prognosis, differentiation, and apoptosis by YONGXIN CHEN, STALLINGS, Raymond L

“…Neuroblastoma accounts for 15% of pediatric cancer deaths, and although a few protein-coding genes, such as MYCN, are involved with aggressive pathogenicity,…”
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Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles by Tivnan, Amanda, Orr, Wayne Shannon, Gubala, Vladimir, Nooney, Robert, Williams, David E, McDonagh, Colette, Prenter, Suzanne, Harvey, Harry, Domingo-Fernández, Raquel, Bray, Isabella M, Piskareva, Olga, Ng, Catherine Y, Lode, Holger N, Davidoff, Andrew M, Stallings, Raymond L

“…Neuroblastoma is one of the most challenging malignancies of childhood, being associated with the highest death rate in paediatric oncology, underlining the…”
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Correction: Metastasis Suppressor microRNA-335 Targets the Formin Family of Actin Nucleators by Lynch, Jennifer, Meehan, Maria H, Crean, John, Copeland, John, Stallings, Raymond L, Bray, Isabella M

“…[This corrects the article DOI: 10.1371/journal.pone.0078428.]…”
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MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma by Tivnan, Amanda, Tracey, Lorraine, Buckley, Patrick G, Alcock, Leah C, Davidoff, Andrew M, Stallings, Raymond L

“…Neuroblastoma is a paediatric cancer which originates from precursor cells of the sympathetic nervous system and accounts for 15% of childhood cancer…”
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Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy by Miller-Delaney, Suzanne F C, Bryan, Kenneth, Das, Sudipto, McKiernan, Ross C, Bray, Isabella M, Reynolds, James P, Gwinn, Ryder, Stallings, Raymond L, Henshall, David C

“…Temporal lobe epilepsy is associated with large-scale, wide-ranging changes in gene expression in the hippocampus. Epigenetic changes to DNA are attractive…”
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MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2 by Foley, Niamh H, Bray, Isabella M, Tivnan, Amanda, Bryan, Kenneth, Murphy, Derek M, Buckley, Patrick G, Ryan, Jacqueline, O'Meara, Anne, O'Sullivan, Maureen, Stallings, Raymond L

“…Neuroblastoma is a paediatric cancer of the sympathetic nervous system. The single most important genetic indicator of poor clinical outcome is amplification…”
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Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis by McKiernan, Ross C, Jimenez-Mateos, Eva M, Bray, Isabella, Engel, Tobias, Brennan, Gary P, Sano, Takanori, Michalak, Zuzanna, Moran, Catherine, Delanty, Norman, Farrell, Michael, O'Brien, Donncha, Meller, Robert, Simon, Roger P, Stallings, Raymond L, Henshall, David C

“…Hippocampal sclerosis (HS) is a common pathological finding in patients with temporal lobe epilepsy (TLE) and is associated with altered expression of genes…”
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Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects by Jimenez-Mateos, Eva M, Engel, Tobias, Merino-Serrais, Paula, McKiernan, Ross C, Tanaka, Katsuhiro, Mouri, Genshin, Sano, Takanori, O'Tuathaigh, Colm, Waddington, John L, Prenter, Suzanne, Delanty, Norman, Farrell, Michael A, O'Brien, Donncha F, Conroy, Ronán M, Stallings, Raymond L, DeFelipe, Javier, Henshall, David C

“…Temporal lobe epilepsy (TLE) is linked to neuron death in the hippocampus. Now David Henshall and colleagues show that miR-134 is upregulated in humans with…”
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MiRNA-335 suppresses neuroblastoma cell invasiveness by direct targeting of multiple genes from the non-canonical TGF-β signalling pathway by LYNCH, Jennifer, FAY, Joanna, MEEHAN, Maria, BRYAN, Kenneth, WATTERS, Karen M, MURPHY, Derek M, STALLINGS, Raymond L

“…Transforming growth factor-β (TGF-β) signaling regulates many diverse cellular activities through both canonical (SMAD-dependent) and non-canonical branches,…”
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The development of cisplatin resistance in neuroblastoma is accompanied by epithelial to mesenchymal transition in vitro by Piskareva, Olga, Harvey, Harry, Nolan, John, Conlon, Ross, Alcock, Leah, Buckley, Patrick, Dowling, Paul, Henry, Michael, O'Sullivan, Finbarr, Bray, Isabella, Stallings, Raymond L

“…Highlights • Cisplatin induced cross resistance to temozolomide, etoposide and irinotecan. • Proteomic profiling of three cisplatin resistant neuroblastoma…”
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LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression by Molenaar, Jan J, Domingo-Fernández, Raquel, Ebus, Marli E, Lindner, Sven, Koster, Jan, Drabek, Ksenija, Mestdagh, Pieter, van Sluis, Peter, Valentijn, Linda J, van Nes, Johan, Broekmans, Marloes, Haneveld, Franciska, Volckmann, Richard, Bray, Isabella, Heukamp, Lukas, Sprüssel, Annika, Thor, Theresa, Kieckbusch, Kristina, Klein-Hitpass, Ludger, Fischer, Matthias, Vandesompele, Jo, Schramm, Alexander, van Noesel, Max M, Varesio, Luigi, Speleman, Frank, Eggert, Angelika, Stallings, Raymond L, Caron, Huib N, Versteeg, Rogier, Schulte, Johannes H

“…Jan Molenaar and colleagues show that LIN28B is overexpressed and amplified in human neuroblastomas and that LIN28B regulates let-7 family miRNAs and MYCN…”
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MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1 by Creevey, Laura, Ryan, Jacqueline, Harvey, Harry, Bray, Isabella M, Meehan, Maria, Khan, Adnan R, Stallings, Raymond L

“…Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates…”
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miR-126 Is Downregulated in Cystic Fibrosis Airway Epithelial Cells and Regulates TOM1 Expression by Oglesby, Irene K, Bray, Isabella M, Chotirmall, Sanjay H, Stallings, Raymond L, O'Neill, Shane J, McElvaney, Noel G, Greene, Catherine M

“…Cystic fibrosis (CF) is one of the most common lethal genetic diseases in which the role of microRNAs has yet to be explored. Predicted to be regulated by…”
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miRNA Expression Profile after Status Epilepticus and Hippocampal Neuroprotection by Targeting miR-132 by Jimenez-Mateos, Eva M, Bray, Isabella, Sanz-Rodriguez, Amaya, Engel, Tobias, McKiernan, Ross C, Mouri, Genshin, Tanaka, Katsuhiro, Sano, Takanori, Saugstad, Julie A, Simon, Roger P, Stallings, Raymond L, Henshall, David C

“…When an otherwise harmful insult to the brain is preceded by a brief, noninjurious stimulus, the brain becomes tolerant, and the resulting damage is reduced…”
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MicroRNA-302d targets IRF9 to regulate the IFN-induced gene expression in SLE by Smith, Siobhán, Fernando, Thilini, Wu, Pei Wen, Seo, Jane, Ní Gabhann, Joan, Piskareva, Olga, McCarthy, Eoghan, Howard, Donough, O'Connell, Paul, Conway, Richard, Gallagher, Phil, Molloy, Eamonn, Stallings, Raymond L, Kearns, Grainne, Forbess, Lindsy, Ishimori, Mariko, Venuturupalli, Swamy, Wallace, Daniel, Weisman, Michael, Jefferies, Caroline A

“…Abstract Systemic lupus erythematosus (SLE) is a complex disease targeting multiple organs as a result of overactivation of the type I interferon (IFN) system,…”
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Widespread dysregulation of MiRNAs by MYCN amplification and chromosomal imbalances in neuroblastoma: association of miRNA expression with survival by Bray, Isabella, Bryan, Kenneth, Prenter, Suzanne, Buckley, Patrick G, Foley, Niamh H, Murphy, Derek M, Alcock, Leah, Mestdagh, Pieter, Vandesompele, Jo, Speleman, Frank, London, Wendy B, McGrady, Patrick W, Higgins, Desmond G, O'Meara, Anne, O'Sullivan, Maureen, Stallings, Raymond L

“…MiRNAs regulate gene expression at a post-transcriptional level and their dysregulation can play major roles in the pathogenesis of many different forms of…”
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Assessment of Basic Biological Functions Exerted by miRNAs by Nolan, John, Stallings, Raymond L, Piskareva, Olga

“…Assessment of cell viability and proliferation under different miRNA expression levels is an important step in the evaluation of basic miRNA functional effects…”
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MiR‐137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A by Althoff, Kristina, Beckers, Anneleen, Odersky, Andrea, Mestdagh, Pieter, Köster, Johannes, Bray, Isabella M., Bryan, Kenneth, Vandesompele, Jo, Speleman, Frank, Stallings, Raymond L., Schramm, Alexander, Eggert, Angelika, Sprüssel, Annika, Schulte, Johannes H.

“…Neuroblastoma is the most common extracranial solid tumor of childhood, and accounts for ∼15% of all childhood cancer deaths. The histone demethylase,…”
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Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma by Soriano, Aroa, Masanas, Marc, Boloix, Ariadna, Masiá, Núria, París-Coderch, Laia, Piskareva, Olga, Jiménez, Carlos, Henrich, Kai-Oliver, Roma, Josep, Westermann, Frank, Stallings, Raymond L., Sábado, Constantino, de Toledo, Josep Sánchez, Santamaria, Anna, Gallego, Soledad, Segura, Miguel F.

“…Current therapies for most non-infectious diseases are directed at or affect functionality of the human translated genome, barely 2% of all genetic…”
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Metastasis suppressor microRNA-335 targets the formin family of actin nucleators by Lynch, Jennifer, Meehan, Maria H, Crean, John, Copeland, John, Stallings, Raymond L, Bray, Isabella M

“…MiRNAs can have pleiotropic effects by targeting multiple genes belonging to diverse signalling networks. Alternatively, miRNAs can enhance the potency of…”
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