Search Results - "STALC, A"

Histidines in affinity tags and surface clusters for immobilized metal-ion affinity chromatography of trimeric tumor necrosis factor α by Gaberc-Porekar, V, Menart, V, Jevševar, S, Videnšek, A, Štalc, A

“…In order to achieve efficient IMAC (immobilized metal-ion affinity chromatography) purification of tumor necrosis factor α (TNF-α) and its analogs by a common…”
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NEW TNF-α ANALOGUES: A POWERFUL BUT LESS TOXIC BIOLOGICAL TOOL AGAINST TUMOURS by Novaković, S., Menart, V., Gaberc-Porekar, V., Štalc, A., Serša, G., Čemažar, M., Jezeršek, B.

“…Our approach to the modification of recombinant human tumour necrosis factor alpha (rhTNF-α) comprised changes in flexible loop regions on the surface of the…”
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Searching for new TNF-alpha analogs having potential application in cancer therapy by Menart, V, Kus, B, Novaković, S, Sersa, G, Gaberc-Porekar, V, Harb, V, Milicić, S, Stalc, A

“…Two new TNF-alpha analogs were prepared and tested for their anti-tumor activity on fibrosarcoma SA-1 tumor model in vivo. In analog LK-801 two histidines…”
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Antitumor effect of recombinant human tumor necrosis factor-alpha analog combined with desmuramyl dipeptides LK-409 or LK-410 on sarcoma in mice by Sersa, G, Novakovic, S, Stalc, A

“…Antitumor effect of recombinant human tumor necrosis factor (TNF)-alpha lacking one to three amino acids from the N terminal part (TNFNv3) was tested for its…”
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The influence of the lipophilicity of 7-oxoacyl- l-alanyl- d-isoglutamines on their immunorestoration activity in vivo by Sollner, M, Pečar, S, Štalc, A

“…In search for immunologically active dipeptides, a series of new N-(7-oxoacyl)- l-alanyl- d-isoglutamines has been synthesized where lipophilicity was varied…”
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Apyrogenic synthetic desmuramyldipeptide, LK-409, with immunomodulatory properties by Sollner, M, Kotnik, V, Pecar, S, Stace, A, Simcic, S, Povsic, L, Herzog-Wraber, B, Klampfer, L, Ihan, A, Grosman, P

“…The synthesis and some immunological characteristics of a new desmuramyl dipeptide 7-oxooctanoyl-L-alanyl-D-isoglutamine (LK-409) are presented. The effects of…”
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QSAR analysis of acetylcholinesterase inhibitors by use of structure similarity methods by Jerman-Blazic, B, Fabic-Petrac, I, Pecar, S, Stalc, A

“…QSAR analysis of acetylcholinesterase inhibitors by a computer system for classification of chemical compounds by use of structure similarity methods has shown…”
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Potential therapeutic indications for synthetic desmuramyl MDP analogue (LK-409) by Kotnik, V, Stalc, A

“…Synthetic desmuramyl analogues are potentially immunostimulating drugs. Until today a lot of different molecules were constructed, some with interesting…”
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An ESR study of the postsynaptic membrane acetylcholinesterase of torpedo marmorata electric organ by Šentjurc, Marjeta, Štalc, A., Župančič, A. O.

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Evaluation of two experimental venous thrombosis models in the rat by Peternel, Luka, Drevenšek, Gorazd, Černe, Manica, Štalc, Anton, Stegnar, Mojca, Budihna, Metka V.

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The influence of soman on the membrane fluidity of rat superior cervical ganglion by Stalc, A, Sentjurc, M, Klinar, B

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Influence of equinatoxin II on coronary smooth muscle membrane fluidity by Sentjurc, M, Stalc, A, Suput, D

“…Equinatoxin II forms pores in artificial as well as in natural phospholipid bylayers. As it also reduces the perfusion through the coronary arteries it seemed…”
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Antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold in two rat venous thrombosis models by Peternel, Luka, Stegnar, Mojca, Drevensek, Gorazd, Budihna, Metka V, Bozic, Mojca, Zega, Anamarija, Stalc, Anton, Cerne, Manica, Urleb, Uros

“…The antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold (LK-732, LK-639 and LK-731) and their amidoxime prodrugs…”
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Nicardipine versus nifedipine: multicentre controlled trial in essential hypertension by Rumboldt, Z, Stojanova, D, Drinovec, J, Marinković, M, Nesović, M, Srbinovski, M, Bagatin, J, Nikodijević, B, Stalc, A

“…Ninety-five hypertensive outpatients of both sexes, aged 23 to 65 years with diastolic blood pressures above 105 but below 120 mmHg (greater than 14.0 but less…”
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Human granulocyte colony stimulating factor (hG-CSF) expressed by methylotrophic yeast pichia pastoris by Lasnik, M A, Porekar, V G, Stalc, A

“…Human granulocyte colony stimulating factor (hG-CSF) was expressed in the methylotrophic yeast Pichia pastoris, using two different constructs which resulted…”
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The influence of TNF on the membrane fluidity of tumor cells by Stalc, A, Sentjurc, M, Sersa, G, Novaković, S

“…Possible TNF (tumor necrosis factor) effects on the membrane fluidity of tumor cells were investigated. Viable tumor cells, TNF sensitive, were obtained from…”
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Improvement of potential therapeutic value of tumor necrosis-alpha (TNF-alpha) by charge modulation in the tip region by Fonda, Irena, Pernus, Mojca, Gaberc-Porekar, Vladka, Kenig, Maja, Stalc, Anton, Meager, Anthony, Menart, Viktor

“…Analysis of published data reveals that the introduction of more basic amino acid residues in the flexible N-terminal region of the human tumour necrosis…”
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Early events in TNFa-p55 receptor interations--experiments with TNF dimers by Menart, V, Gaberc-Porekar, V, Jevsevar, S, Pernus, M, Meager, A, Stalc, A

“…The first essential step in TNF signal transduction is believed to be clustering of the membrane bound receptors around the trimeric TNF molecule. To check if…”
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N-{trans-2-[[2‘-(Acetylamino)cyclohexyl]oxy]acetyl}-l-alanyl-d-glutamic Acid:  A Novel Immunologically Active Carbocyclic Muramyl Dipeptide Analogue by Kikelj, Danijel, Pečar, Slavko, Kotnik, Vladimir, Štalc, Anton, Wraber-Herzog, Branka, Simčič, Saša, Ihan, Alojz, Klamfer, Lidija, Povšič, Lučka, Grahek, Rok, Suhadolc, Elizabeta, Hočevar, Mirjam, Hönig, Helmut, Rogi-Kohlenprath, Renate

“…A novel non-pyrogenic carbocyclic muramyl dipeptide (MDP) analogue, N-{trans-2-[[2‘-(acetylamino)cyclohexyl]oxy]acetyl}-l-alanyl-d-glutamic acid, was obtained…”
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Subchronic toxicity of substance LK-404 by Lavric, A., Culjak, K., Tibaut, D., Nemec, M., Stalc, A.

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