Search Results - "STAHL, Andrea M"
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Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary Neurons
Published in The Journal of biological chemistry (16-02-2007)“…An efficient research strategy integrating empirically guided, structure-based modeling and chemoinformatics was used to discover potent small molecule…”
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Gaining ground: assays for therapeutics against botulinum neurotoxin
Published in Trends in microbiology (Regular ed.) (01-04-2010)“…Owing in part to recently heightened concern over bioterrorism, interest in the mechanism of action of botulinum neurotoxin (BoNT) and development of effective…”
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Primary cultures of embryonic chicken neurons for sensitive cell-based assay of botulinum neurotoxin: implications for therapeutic discovery
Published in Journal of biomolecular screening (01-04-2007)“…Botulinum toxin is an exceedingly potent inhibitor of neurotransmission across the neuromuscular junction, causing flaccid paralysis and death. The potential…”
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Accelerating botulism therapeutic product development in the Department of Defense
Published in Drug development research (01-06-2009)“…Coordinated small‐molecule drug discovery research efforts for the treatment of botulism by the public sector, especially the U.S. Department of Defense (DoD)…”
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Reduced blood-to-tissue albumin movement after plasmapheresis
Published in Shock (Augusta, Ga.) (01-05-2003)“…We tested the hypothesis that a decrease in the blood-to-tissue movement of albumin contributes to the recovery of plasma albumin and plasma volume after acute…”
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