Search Results - "STAFFORINI, Diana M"

Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2 by Rosenson, Robert S., Stafforini, Diana M.

“…Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet-activating factor acetylhydrolase (PAF-AH), is a unique member of the phospholipase…”
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Biology of Platelet-activating Factor Acetylhydrolase (PAF-AH, Lipoprotein Associated Phospholipase A2) by Stafforini, Diana M.

“…Introduction This article is focused on platelet-activating factor acetylhydrolase (PAF-AH), a lipoprotein bound, calcium-independent phospholipase A 2…”
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Function and regulation of retinoic acid-inducible gene-I by Matsumiya, Tomoh, Stafforini, Diana M

“…Antiviral innate immunity is triggered by sensing viral nucleic acids. RIG-I (retinoic acid-inducible gene-I) is an intracellular molecule that responds to…”
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The emerging roles of PAF acetylhydrolase by McIntyre, Thomas M., Prescott, Stephen M., Stafforini, Diana M.

“…Platelet-activating factor (PAF), a phospholipid autacoid with potent effects throughout the innate immune system, is selectively degraded by two small…”
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Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation[S] by Kan, Chin Fung Kelvin, Singh, Amar Bahadur, Stafforini, Diana M., Azhar, Salman, Liu, Jingwen

“…ACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for arachidonic acid (AA) as its substrate. Although an…”
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New perspectives on APC control of cell fate and proliferation in colorectal cancer by Phelps, Reid A., Broadbent, Talmage J., Stafforini, Diana M., Jones, David A.

“…Aberrant Wnt/β-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation…”
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Release of Free F2-isoprostanes from Esterified Phospholipids Is Catalyzed by Intracellular and Plasma Platelet-activating Factor Acetylhydrolases by Stafforini, Diana M., Sheller, James R., Blackwell, Timothy S., Sapirstein, Adam, Yull, Fiona E., McIntyre, Thomas M., Bonventre, Joseph V., Prescott, Stephen M., Roberts, L. Jackson

“…F2-isoprostanes are produced in vivo by nonenzymatic peroxidation of arachidonic acid esterified in phospholipids. Increased urinary and plasma F2-isoprostane…”
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The platelet-activating factor signaling system and its regulators in syndromes of inflammation and thrombosis by Zimmerman, Guy A, McIntyre, Thomas M, Prescott, Stephen M, Stafforini, Diana M

“…OBJECTIVESTo review the platelet-activating factor (PAF) signaling system, its regulation, and its dysregulation in acute inflammation and thrombosis and in…”
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Dual Roles of Endogenous Platelet-Activating Factor Acetylhydrolase in a Murine Model of Necrotizing Enterocolitis by Lu, Jing, Pierce, Marissa, Franklin, Andrew, Jilling, Tamas, Stafforini, Diana M, Caplan, Michael

“…Human preterm infants with necrotizing enterocolitis (NEC) have increased circulating and luminal levels of platelet-activating factor (PAF) and decreased…”
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Identification of a Domain That Mediates Association of Platelet-activating Factor Acetylhydrolase with High Density Lipoprotein by Gardner, Alison A., Reichert, Ethan C., Topham, Matthew K., Stafforini, Diana M.

“…The plasma form of platelet-activating factor (PAF) acetylhydrolase (PAF-AH), also known as lipoprotein-associated phospholipase A2 (Lp-PLA2) inactivates…”
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PLATELET-ACTIVATING FACTOR AND RELATED LIPID MEDIATORS by Prescott, Stephen M, Zimmerman, Guy A, Stafforini, Diana M, McIntyre, Thomas M

“…Platelet-activating factor (PAF) is a phospholipid with potent, diverse physiological actions, particularly as a mediator of inflammation. The synthesis,…”
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Association Between 5-Lipoxygenase Expression and Plaque Instability in Humans by Cipollone, Francesco, Mezzetti, Andrea, Fazia, Maria Luigia, Cuccurullo, Chiara, Iezzi, Annalisa, Ucchino, Sante, Spigonardo, Francesco, Bucci, Marco, Cuccurullo, Franco, Prescott, Stephen M, Stafforini, Diana M

“…OBJECTIVE—The participation of 5-lipoxygenase (5-LO) in the development of atherosclerosis has been suggested by recent studies. However, a role for 5-LO as a…”
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The role of cyclooxygenase-2 and prostaglandins in colon cancer by Eisinger, Annie L., Prescott, Stephen M., Jones, David A., Stafforini, Diana M.

“…The temporal association between loss of function of the tumor suppressor adenomatous polyposis coli (APC) and overexpression of cyclooxygenase 2 (COX-2) has…”
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Functional Consequences of Mutations and Polymorphisms in the Coding Region of the PAF Acetylhydrolase (PAF-AH) Gene by Stafforini, Diana M

“…In the past several years a number of alterations in the PAFAH/PLA₂G7/LpPLA₂ gene have been described. These include inactivating mutations, polymorphisms in…”
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Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes by Ajiro, Yoichi, Saegusa, Noriko, Giles, Wayne R, Stafforini, Diana M, Spitzer, Kenneth W

“…Sodium-hydrogen exchanger (NHE), the principal sarcolemmal acid extruder in ventricular myocytes, is stimulated by a variety of autocrine/paracrine factors and…”
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The Adenomatous Polyposis Coli Tumor Suppressor Gene Regulates Expression of Cyclooxygenase-2 by a Mechanism That Involves Retinoic Acid by Eisinger, Annie L., Nadauld, Lincoln D., Shelton, Dawne N., Peterson, Peter W., Phelps, Reid A., Chidester, Stephanie, Stafforini, Diana M., Prescott, Stephen M., Jones, David A.

“…Mutations in the adenomatous polyposis coli (APC) gene result in uncontrolled proliferation of intestinal epithelial cells and are associated with the earliest…”
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Deficiency of Phospholipase A2 Group 7 Decreases Intestinal Polyposis and Colon Tumorigenesis in ApcMin/+ Mice by CHANGXIN XU, REICHERT, Ethan C, NAKANO, Tomoyuki, LOHSE, Mariah, GARDNER, Alison A, REVELO, Mónica P, TOPHAM, Matthew K, STAFFORINI, Diana M

“…Abstract Platelet-activating factor (PAF) is a naturally occurring phospholipid that mediates diverse effects such as physiological and pathological…”
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Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression by Al-Salihi, Mazin A, Terrece Pearman, A, Doan, Thao, Reichert, Ethan C, Rosenberg, Daniel W, Prescott, Stephen M, Stafforini, Diana M, Topham, Matthew K

“…Abstract We generated mice expressing a COX-2 transgene in colon epithelium and found that they did not develop spontaneous colon tumors. But when treated with…”
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Deletion of diacylglycerol kinase ε confers susceptibility to obesity via reduced lipolytic activity in murine adipocytes by Nakano, Tomoyuki, Seino, Keiko, Wakabayashi, Ichiro, Stafforini, Diana M., Topham, Matthew K., Goto, Kaoru

“…Lipid metabolism is closely involved with signal transduction and energy homeostasis. Excess calorie intake causes abnormal lipid metabolism, promoting obesity…”
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Unraveling the PAF-AH/Lp-PLA2 controversy by Stafforini, Diana M, Zimmerman, Guy A

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