Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years

A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. The effect of...

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Bibliographic Details
Published in:	International journal of epidemiology Vol. 32; no. 1; pp. 60 - 63
Main Authors:	TAIOLI, E, GASPARI, L, HIRVONEN, A, HUSGAFVEL-PURSIAINEN, K, KALINA, I, KREMERS, P, LE MARCHAND, L, LONDON, S, RANNUG, A, ROMKES, M, SCHOKET, B, SEIDEGARD, J, BENHAMOU, S, STRANGE, R. C, STACKER, I, TO-FIGUERAS, J, GARTE, S, BOFFETTA, P, BROCKMOLLER, J, BUTKIEWICZ, D, CASCORBI, I, CLAPPER, M. L, DOLZAN, V, HAUGEN, A
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 01-02-2003 Oxford Publishing Limited (England) Oxford University Press (OUP)
Subjects:	Adult Age of Onset Biological and medical sciences Case-Control Studies Chi-Square Distribution Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP1A1 - genetics Databases, Factual Factor Analysis, Statistical Female Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Genetic Predisposition to Disease Glutathione Transferase Glutathione Transferase - genetics Health Sciences Humans Hälsovetenskap Life Sciences Lung Neoplasms Lung Neoplasms - genetics Male Medical and Health Sciences Medical sciences Medicin och hälsovetenskap Pneumology Polymorphism, Genetic Public Health, Global Health, Social Medicine and Epidemiology Risk Factors Santé publique et épidémiologie Smoking Smoking - adverse effects Tumors of the respiratory system and mediastinum Human Lung disease Respiratory disease Tobacco smoking Malignant tumor Genetic determinism Epidemiology Bronchopulmonary Carcinogen Gene Young adult Risk factor Bronchus disease Polymorphism
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Summary:	A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and </=45 years of age at diagnosis, and the corresponding controls were selected. We obtained 261 cases and 1452 controls. There was a marginally significant association between lung cancer and GSTT1 null genotype (OR=1.2; 95% CI:1.0-1.6), and a significant association between lung cancer and the homozygous CYP1A1 Msp1 variant allele (CYP1A12A and 2B) genotype (OR=4.7 95% CI:1.2-19.0). When data were stratified by smoking status, the association between CYP1A1 genotype and lung cancer was confined to never smokers. These results suggest that metabolic genetic factors play a role in lung cancer developing at young ages.
ISSN:	0300-5771 1464-3685 1464-3685
DOI:	10.1093/ije/dyg001