Search Results - "SRINIVASAN SRIMATKANDADA"

Combined proteasome and Bcl-2 inhibition stimulates apoptosis and inhibits growth in EBV-transformed lymphocytes: a potential therapeutic approach to EBV-associated lymphoproliferative diseases by Srimatkandada, Pavani, Loomis, Regina, Carbone, Rocco, Srimatkandada, Srinivasan, Lacy, Jill

“…Objectives:  Epstein–Barr virus (EBV) transforms B‐cells into immortalized lymphoblastoid cells (LCLs) by triggering signaling pathways that lead to activation…”
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Peptides Inhibitory for the Transcriptional Regulatory Function of Human Papillomavirus E2 by FUJII, Takuma, AUSTIN, David, GUO, David, SRIMATKANDADA, Srinivasan, TAO WANG, KUBUSHIRO, Kaneyuki, MASUMOTO, Nobuo, TSUKAZAKI, Katsumi, NOZAWA, Shiro, DEISSEROTH, Albert B

“…Purpose: Human papillomavirus (HPV) infections are associated with cervical neoplasia. Cellular and viral proteins are known to interact with the…”
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High and Low Levels of Cottontail Rabbit Papillomavirus E2 Protein Generate Opposite Effects on Gene Expression by Fujii, Takuma, Brandsma, Janet L., Peng, Xueyan, Srimatkandada, Srinivasan, Li, Lei, Canaan, Allon, Deisseroth, Albert B.

“…The papillomavirus E2 protein plays an important role in viral transcriptional regulation and replication. We chose to study the cottontail rabbit…”
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Sensitivity of K562 human chronic myelogenous leukemia blast cells transfected with a human multidrug resistance cDNA to cytotoxic drugs and differentiating agents by HAIT, W. N, CHOUDHURY, S, SRINIVASAN SRIMATKANDADA, MURREN, J. R

“…The blast crisis of chronic myelogenous leukemia (CML) is refractory to most forms of cancer chemotherapy, but may be amenable to drugs that differentiate…”
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Bleomycin hydrolase: molecular cloning, sequencing, and biochemical studies reveal membership in the cysteine proteinase family by Sebti, Said M, Mignano, John E, Jani, Jitesh P, Srimatkandada, Srinivasan, Lazo, John S

“…Bleomycin (BLM) hydrolase catalyzes the inactivation of the antitumor drug BLM and is believed to protect normal and malignant cells from BLM toxicity. The…”
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Increased rate of adenosine triphosphate-dependent etoposide (VP-16) efflux in a murine leukemia cell line overexpressing the multidrug resistance-associated protein (MRP) gene by LORICO, A, RAPPA, G, SRINIVASAN SRIMATKANDALA, CATAPANO, C. V, FERNANDES, D. J, GERMINO, J. F, SARTORELLI, A. C

“…WEHI-3B/NOVO is a cloned murine leukemia cell line selected for resistance to novobiocin that is cross-resistant to the cytotoxic action of etoposide (VP-16)…”
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RECOMBINANT GLYCOPROTEIN (GP)IIIa OLIGOPEPTIDES REACT WITH PLATELET AUTOANTIBODIES. ▴ 897 by Beardsley, Diana S, Tang, Caroline, Gomes, Eric, Hajjar, Fouad, Holtkamp, Christine, Srimatkandada, Srinivasan, Lamborn, Carolyn

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Amplification of a Polymorphic Dihydrofolate Reductase Gene Expressing an Enzyme with Decreased Binding to Methotrexate in a Human Colon Carcinoma Cell Line, HCT-8R4, Resistant to This Drug by Srimatkandada, S, Schweitzer, B I, Moroson, B A, Dube, S, Bertino, J R

“…A methotrexate (MTX)-resistant human colon carcinoma cell line was obtained by growing HCT-8 cells in stepwise increasing concentrations of the drug. The…”
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Probing the role of two hydrophobic active site residues in the human dihydrofolate reductase by site-directed mutagenesis by Schweitzer, B.I., Srimatkandada, S, Gritsman, H, Sheridan, R, Venkataraghavan, R, Bertino, J.R.

“…In the x-ray structure of the human dihydrofolate reductase, phenylalanine 31 and phenylalanine 34 have been shown to be involved in hydrophobic interactions…”
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Coamplification of 3-hydroxy-3-methylglutaryl coenzyme A reductase genes in methotrexate-resistant human leukemia cell lines by Srimatkandada, S, Dube, S K, Carmen, M, Bertino, J R

“…Methotrexate (MTX)-resistant K562 human myelocytic leukemia sublines with 20- and 200-fold amplified dihydrofolate reductase (DHFR) genes localized to…”
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Molecular and karyological analysis of methotrexate-resistant and -sensitive human leukemic CCRF-CEM cells by MINI, E, SRIMATKANDADA, S, MEDINA, W. D, MOROSON, B. A, CARMAN, M. D, BERTINO, J. R

“…A methotrexate-resistant subline, CCRF-CEM/R1, was selected stepwise from the human leukemic lymphoblast T-cell line, CCRF-CEM, and maintained in 0.2 microM…”
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Amplification and organization of dihydrofolate reductase genes in a human leukemic cell line, K-562, resistant to methotrexate by Srimatkandada, Srinivasan, Medina, William D, Cashmore, Arlene R, Whyte, Wendy, Engel, Daniel, Moroson, Barbara A, Franco, Christine T, Dube, Shyam K, Bertino, Joseph R

“…A subline of human leukemia cells (K-562), highly resistant to methotrexate, was developed by stepwise selection in the presence of increasing concentrations…”
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