Search Results - "SRINIVASAN, Mohan"

Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab by Ramagopal, Udupi A., Liu, Weifeng, Garrett-Thomson, Sarah C., Bonanno, Jeffrey B., Yan, Qingrong, Srinivasan, Mohan, Wong, Susan C., Bell, Alasdair, Mankikar, Shilpa, Rangan, Vangipuram S., Deshpande, Shrikant, Korman, Alan J., Almo, Steven C.

“…Rational modulation of the immune response with biologics represents one of the most promising and active areas for the realization of new therapeutic…”
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Real-Time Processor-in-Loop Investigation of a Modified Non-Linear State Observer Using Sliding Modes for Speed Sensorless Induction Motor Drive in Electric Vehicles by Krishna Srinivasan, Mohan, Daya John Lionel, Febin, Subramaniam, Umashankar, Blaabjerg, Frede, Madurai Elavarasan, Rajvikram, Shafiullah, G. M., Khan, Irfan, Padmanaban, Sanjeevikumar

“…Tracking performance and stability play a major role in observer design for speed estimation purpose in motor drives used in vehicles. It is all the more…”
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Glycan optimization of a human monoclonal antibody in the aquatic plant Lemna minor by Cox, K.M, Sterling, J.D, Regan, J.T, Gasdaska, J.R, Frantz, K.K, Peele, C.G, Black, A, Passmoe, D, Moldovan-Loomis, C, Srinivasan, M

“…N-glycosylation is critical to the function of monoclonal antibodies (mAbs) and distinguishes various systems used for their production. We expressed human…”
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Pharmacokinetic characterization of BMS-936561, an anti-CD70 antibody-drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans by Wang, Haiqing, Rangan, Vangipuram S., Sung, Mei-Chen, Passmore, David, Kempe, Thomas, Wang, Xiaoli, Thevanayagam, Lourdes, Pan, Chin, Rao, Chetana, Srinivasan, Mohan, Zhang, Qian, Gangwar, Sanjeev, Deshpande, Shrikant, Cardarelli, Pina, Marathe, Punit, Yang, Zheng

“…CD70 is a tumor necrosis factor (TNF)‐like type II integral membrane protein that is transiently expressed on activated T‐ and B‐lymphocytes. Aberrant…”
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Technological Perspective of Cyber Secure Smart Inverters Used in Power Distribution System: State of the Art Review by Surya, Sumukh, Srinivasan, Mohan Krishna, Williamson, Sheldon

“…The purpose of smart grid architecture as compared to the conventional grid is to ensure more stability, reliability and bi-directional communication between…”
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Differences in Electrostatic Properties at Antibody–Antigen Binding Sites: Implications for Specificity and Cross-Reactivity by Sinha, Neeti, Mohan, Srinivasan, Lipschultz, Claudia A., Smith-Gill, Sandra J.

“…Antibodies HyHEL8, HyHEL10, and HyHEL26 (HH8, HH10, and HH26, respectively) recognize highly overlapping epitopes on hen egg-white lysozyme (HEL) with similar…”
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Inner Resonance and Outer Current Based Control Strategy for Inductive Power Transfer System Used in Wireless Charging for Electric Vehicles by Varikkottil, Sooraj, Lionel, Febin Daya John, Srinivasan, Mohan Krishna, Perumal, Thinagaran, Stonier, Albert Alexander, Peter, Geno, Pagidi, Balachennaiah, Ganji, Vivekananda

“…The wireless charging for electric vehicle is getting popular due to the absence of sophisticated cable connection and associated issues with the actuators in…”
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Role of Power Converters in Inductive Power Transfer System for Public Transport—A Comprehensive Review by Varikkottil, Sooraj, Lionel, Febin Daya John, Srinivasan, Mohan Krishna, Williamson, Sheldon, Kannan, Ramani, Izhar, Lila Iznita

“…IPT (inductive power transfer) charging is a highly flexible concept that allows for charging at any possible opportunity and is highly versatile for vehicles…”
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In vitro and In vivo Characterization of MDX-1401 for Therapy of Malignant Lymphoma by CARDARELLI, Pina M, MOLDOVAN-LOOMIS, Maria-Cristina, ASSAD, Albert, WITTE, Alison, GRAZIANO, Robert F, KING, David J, PRESTON, Ben, BLACK, Amelia, PASSMORE, David, CHEN, Tseng-Hui, CHEN, Sharline, JIE LIU, KUHNE, Michelle R, SRINIVASAN, Mohan

“…Purpose: This study was undertaken to evaluate the effects of MDX-1401, a nonfucosylated fully human monoclonal antibody that binds to human CD30, and to…”
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Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells by Selby, Mark J, Engelhardt, John J, Quigley, Michael, Henning, Karla A, Chen, Timothy, Srinivasan, Mohan, Korman, Alan J

“…Antitumor activity of CTLA-4 antibody blockade is thought to be mediated by interfering with the negative regulation of T-effector cell (Teff) function…”
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In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates by Wang, Changyu, Thudium, Kent B, Han, Minhua, Wang, Xi-Tao, Huang, Haichun, Feingersh, Diane, Garcia, Candy, Wu, Yi, Kuhne, Michelle, Srinivasan, Mohan, Singh, Sujata, Wong, Susan, Garner, Neysa, Leblanc, Heidi, Bunch, R Todd, Blanset, Diann, Selby, Mark J, Korman, Alan J

“…The programmed death-1 (PD-1) receptor serves as an immunologic checkpoint, limiting bystander tissue damage and preventing the development of autoimmunity…”
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Constrained optimal power flow and optimal TCSC allocation using hybrid cuckoo search and ant lion optimizer by Mahapatra, Sheila, Malik, Nitin, Raj, Saurav, Srinivasan, Mohan Krishna

“…This paper works on the solution to Voltage Constrained Optimal Power Flow (VCOPF) problem with the requisite allocation of thyristor-controlled series…”
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Mapping binding epitopes of monoclonal antibodies targeting major histocompatibility complex class I chain-related A (MICA) with hydrogen/deuterium exchange and electron-transfer dissociation mass spectrometry by Huang, Richard Y.-C., Kuhne, Michelle, Deshpande, Shrikant, Rangan, Vangipuram, Srinivasan, Mohan, Wang, Yun, Chen, Guodong

“…Major histocompatibility complex class I chain-related A and B (MICA/B) are cell-surface proteins that act as ligands to natural killer cell receptors, NKG2D,…”
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Fucosyl monosialoganglioside: Quantitative analysis of specific potential biomarkers of lung cancer in biological matrices using immunocapture extraction/tandem mass spectrometry by Ranasinghe, Asoka, Mehl, John, D'Arienzo, Celia, Nabbie, Fizal, Chiu, Christopher, Thevanayagam, Lourdes, Srinivasan, Mohan, Hogan, Jason, Ponath, Paul, Olah, Timothy

“…Rationale Certain lung cancer patients express elevated Fucosyl Monosialoganglioside (Fuc‐GM1) in circulation compared to control groups. Several sensitive…”
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Hydrogen/deuterium exchange mass spectrometry and computational modeling reveal a discontinuous epitope of an antibody/TL1A Interaction by Huang, Richard Y-C, Krystek, Jr, Stanley R, Felix, Nathan, Graziano, Robert F, Srinivasan, Mohan, Pashine, Achal, Chen, Guodong

“…TL1A, a tumor necrosis factor-like cytokine, is a ligand for the death domain receptor DR3. TL1A, upon binding to DR3, can stimulate lymphocytes and trigger…”
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Abstract 6055: Discovery of epitope-selective anti-CD25 targeting therapeutic antibodies for effective Treg cell depletion in cancer using a novel AI/ML based platform by Gip, Phung, Li, Bing, Estelles, Angeles, Daino-Laizure, Hanako, Gurinovich, Oleg, Zalicki, Piotr, Hauser, Kevin, Taguchi, Alex, Barrett, Christian, Morin, Andrew, Willis, Jordan, Srinivasan, Mohan, Bright, Isaac, Greving, Matt

“…Abstract Therapeutic antibodies have contributed significantly to better clinical outcomes across multiple tumor types. However, there is still unmet clinical…”
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Synthesis and Characterization of Binding Interaction of ZnO Nanoparticles with Organic Compounds by Mohan, Srinivasan, Sudarsan, Shanmugavel, Parthiban, Elumalai, Guhanatahan, Selvam, Prasad, SVS

“…The current research investigated an unique type of fluorescent sensitive imidazole based on…”
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Abstract 1872: A next generation treatment for Nectin-4 positive cancers - Preclinical characterization of LY4052031, an anti-Nectin-4 antibody, conjugated to a novel camptothecin payload by Sagar, Divya, Srinivasan, Mohan, Lindquist, Kevin, Guo, Qianxu, Wong, Wailin, Lebron, Maria B., Sattler, Rose Marie, Zhou, Jieyu, Helms, Whitney, Boyles, Jeffrey, Verdino, Petra, Zhao, Xuan, Mak, Yvonne, Park, Joshua, Holmgaard, Rikke, Driscoll, Kyla, Duramad, Omar, Bedard, Kristin

“…Abstract Nectin-4 is an immunoglobulin-like antigen overexpressed in a variety of cancers including bladder, breast, NSCLC, and gastric. Normal tissues…”
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Production of human monoclonal antibody in eggs of chimeric chickens by Etches, Robert J, Zhu, Lei, van de Lavoir, Marie-Cecile, Albanese, Jenny, Beenhouwer, David O, Cardarelli, Pina M, Cuison, Severino, Deng, David F, Deshpande, Shrikant, Diamond, Jennifer H, Green, Lynae, Halk, Edward L, Heyer, Babette S, Kay, Robert M, Kerchner, Allyn, Leighton, Philip A, Mather, Christine M, Morrison, Sherie L, Nikolov, Zivko L, Passmore, David B, Pradas-Monne, Alicia, Preston, Benjamin T, Rangan, Vangipuram S, Shi, Mingxia, Srinivasan, Mohan, White, Steven G, Winters-Digiacinto, Peggy, Wong, Susan, Zhou, Wen

“…The tubular gland of the chicken oviduct is an attractive system for protein expression as large quantities of proteins are deposited in the egg, the…”
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Novel detection of DNA-alkylated adducts of antibody-drug conjugates with potentially unique preclinical and biomarker applications by Thevanayagam, Lourdes, Bell, Alasdair, Chakraborty, Indrani, Sufi, Bilal, Gangwar, Sanjeev, Zang, Allen, Rangan, Vangipuram, Rao, Chetana, Wang, Zemin, Pan, Chin, Chong, Coling, Cardarelli, Pina, Deshpande, Shrikant, Srinivasan, Mohan

“…MDX-1203 is an antibody-drug conjugate (ADC) currently in clinical trials for the treatment of renal carcinoma. The active ingredient of MDX-1203 is a DNA…”
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