Search Results - "SRIDHAR, Akshay"

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions by Krainer, Georg, Welsh, Timothy J., Joseph, Jerelle A., Espinosa, Jorge R., Wittmann, Sina, de Csilléry, Ella, Sridhar, Akshay, Toprakcioglu, Zenon, Gudiškytė, Giedre, Czekalska, Magdalena A., Arter, William E., Guillén-Boixet, Jordina, Franzmann, Titus M., Qamar, Seema, George-Hyslop, Peter St, Hyman, Anthony A., Collepardo-Guevara, Rosana, Alberti, Simon, Knowles, Tuomas P. J.

“…Liquid–liquid phase separation of proteins underpins the formation of membraneless compartments in living cells. Elucidating the molecular driving forces…”
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Structural and dynamic mechanisms of GABAA receptor modulators with opposing activities by Zhu, Shaotong, Sridhar, Akshay, Teng, Jinfeng, Howard, Rebecca J., Lindahl, Erik, Hibbs, Ryan E.

“…γ-Aminobutyric acid type A (GABA A ) receptors are pentameric ligand-gated ion channels abundant in the central nervous system and are prolific drug targets…”
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Emergence of chromatin hierarchical loops from protein disorder and nucleosome asymmetry by Sridhar, Akshay, Farr, Stephen E., Portella, Guillem, Schlick, Tamar, Orozco, Modesto, Collepardo-Guevara, Rosana

“…Protein flexibility and disorder is emerging as a crucial modulator of chromatin structure. Histone tail disorder enables transient binding of different…”
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Surface Electrostatics Govern the Emulsion Stability of Biomolecular Condensates by Welsh, Timothy J, Krainer, Georg, Espinosa, Jorge R, Joseph, Jerelle A, Sridhar, Akshay, Jahnel, Marcus, Arter, William E, Saar, Kadi L, Alberti, Simon, Collepardo-Guevara, Rosana, Knowles, Tuomas P. J

“…Liquid–liquid phase separation underlies the formation of biological condensates. Physically, such systems are microemulsions that in general have a propensity…”
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A Library of Large‐Eddy Simulations Forced by Global Climate Models by Shen, Zhaoyi, Sridhar, Akshay, Tan, Zhihong, Jaruga, Anna, Schneider, Tapio

“…Advances in high‐performance computing have enabled large‐eddy simulations (LES) of turbulence, convection, and clouds. However, their potential to improve…”
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Coarse-grain molecular dynamics study of fullerene transport across a cell membrane by Sridhar, Akshay, Srikanth, Bharath, Kumar, Amit, Dasmahapatra, Ashok Kumar

“…The study of the ability of drug molecules to enter cells through the membrane is of vital importance in the field of drug delivery. In cases where the…”
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Waterdock 2.0: Water placement prediction for Holo-structures with a pymol plugin by Sridhar, Akshay, Ross, Gregory A, Biggin, Philip C

“…Water is often found to mediate interactions between a ligand and a protein. It can play a significant role in orientating the ligand within a binding pocket…”
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Markov state modelling reveals heterogeneous drug-inhibition mechanism of Calmodulin by Westerlund, Annie M., Sridhar, Akshay, Dahl, Leo, Andersson, Alma, Bodnar, Anna-Yaroslava, Delemotte, Lucie

“…Calmodulin (CaM) is a calcium sensor which binds and regulates a wide range of target-proteins. This implicitly enables the concentration of calcium to…”
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Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain by Chi, Gamma, Liang, Qiansheng, Sridhar, Akshay, Cowgill, John B., Sader, Kasim, Radjainia, Mazdak, Qian, Pu, Castro-Hartmann, Pablo, Venkaya, Shayla, Singh, Nanki Kaur, McKinley, Gavin, Fernandez-Cid, Alejandra, Mukhopadhyay, Shubhashish M. M., Burgess-Brown, Nicola A., Delemotte, Lucie, Covarrubias, Manuel, Dürr, Katharina L.

“…Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in…”
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Protein disorder-to-order transition enhances the nucleosome-binding affinity of H1 by Sridhar, Akshay, Orozco, Modesto, Collepardo-Guevara, Rosana

“…Intrinsically disordered proteins are crucial elements of chromatin heterogenous organization. While disorder in the histone tails enables a large variation of…”
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Content-based image retrieval of digitized histopathology in boosted spectrally embedded spaces by Sridhar, Akshay, Doyle, Scott, Madabhushi, Anant

“…Context: Content-based image retrieval (CBIR) systems allow for retrieval of images from within a database that are similar in visual content to a query image…”
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Subtype-specific modulation of human K<inf>V</inf>7 channels by the anticonvulsant cannabidiol through a lipid-exposed pore-domain site by Pökl, Michael, Sridhar, Akshay, Frampton, Damon J.A., Linhart, Veronika A., Delemotte, Lucie, Liin, Sara I.

“…Background and Purpose: Cannabidiol (CBD) is used clinically as an anticonvulsant. Its precise mechanism of action has remained unclear. CBD was recently…”
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Subtype-specific modulation of human K(V)7 channels by the anticonvulsant cannabidiol through a lipid-exposed pore-domain site by Pökl, Michael, Sridhar, Akshay, Frampton, Damon, Linhart, Veronika, Delemotte, Lucie, Liin, Sara

“…Background and PurposeCannabidiol (CBD) is used clinically as an anticonvulsant. Its precise mechanism of action has remained unclear. CBD was recently…”
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Phosphorylation of Intrinsically Disordered Regions within the Genome by Sridhar, Akshay, Portella, Guillem, Orozco, Modesto, Collepardo-Guevara, Rosana

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Regulation of pentameric ligand-gated ion channels by a semiconserved cation-pi interaction site by Sridhar, Akshay, Lummis, Sarah C., Lindahl, Erik, Howard, Rebecca J., Ulens, Chris

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Structural and dynamic mechanisms of GABA(A) receptor modulators with opposing activities by Zhu, Shaotong, Sridhar, Akshay, Teng, Jinfeng, Howard, Rebecca J., Lindahl, Erik, Hibbs, Ryan E.

“…gamma-Aminobutyric acid type A (GABA(A)) receptors are pentameric ligand-gated ion channels abundant in the central nervous system and are prolific drug…”
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Multi-scale molecular dynamics study of cholera pentamer binding to a GM1-phospholipid membrane by Sridhar, Akshay, Kumar, Amit, Dasmahapatra, Ashok Kumar

“…[Display omitted] •Interaction of Cholera ‘B’ Pentamer with an asymmetrical GM1-DPPC bilayer is studied.•The bound configuration consists of only three ‘B’…”
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Subtype-specific modulation of human K V 7 channels by the anticonvulsant cannabidiol through a lipid-exposed pore-domain site by Pökl, Michael, Sridhar, Akshay, Frampton, Damon J A, Linhart, Veronika A, Delemotte, Lucie, Liin, Sara I

“…Cannabidiol (CBD) is used clinically as an anticonvulsant. Its precise mechanism of action has remained unclear. CBD was recently demonstrated to enhance the…”
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The anticonvulsant Cannabidiol acts disparately on human voltage-gated potassium channels Kv7 via similar sites by Pokl, M., Frampton, D., Sridhar, Akshay, Linhart, V., Choudhury, Koushik, Delemotte, Lucie, Liin, S.

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Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site by Sridhar, Akshay, Lummis, Sarah C.R., Pasini, Diletta, Mehregan, Aujan, Brams, Marijke, Kambara, Kumiko, Bertrand, Daniel, Lindahl, Erik, Howard, Rebecca J., Ulens, Chris

“…Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical signal transduction in various organisms from bacteria to humans. Lipids…”
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