Apolipoprotein E and Presenilin-1 Allelic Variation and Alzheimer's Disease in India

Apolipoprotein E and Presenilin-1 Allelic Variation and Alzheimer's Disease in India

As part of a larger epidemiological survey to study the prevalence of dementia in a suburb of Mumbai, Western India, we identified 78 cases with a Clinical Dementia Rating (CDR) ≥ 1.0. Of these, 49 Alzheimer's disease (AD) cases were analyzed for risk association with APOE E*4 allele at apolipo...

Full description

Saved in:
Bibliographic Details
Published in:Human biology Vol. 74; no. 5; pp. 683 - 693
Main Authors: CHANDAK, G.R., SRIDEVI, M. UMA, VAS, C.J., PANIKKER, D.M., SINGH, L.
Format: Journal Article
Language:English
Published: United States Wayne State University Press 01-10-2002
Subjects:
Aged
Aged, 80 and over
Alleles
Alzheimer Disease - diagnosis
Alzheimer Disease - epidemiology
Alzheimer Disease - genetics
Alzheimer's disease
Alzheimers disease
Amyloids
Apolipoprotein E4
Apolipoproteins
Apolipoproteins E - genetics
Case-Control Studies
Causes of
Degeneration
Dementia
Epidemiology
Gene frequency
Genes
Genetic aspects
Genetic Testing
Genetic Variation - genetics
Genetics
Genetics, Population
Genotype
Genotypes
Humans
India - epidemiology
Introns - genetics
Medical genetics
Membrane Proteins - genetics
Mental Status Schedule
Middle Aged
Nerve degeneration
Nervous system
Neurodegenerative diseases
Polymorphism, Genetic - genetics
Population genetics
Predisposing factors
Presenilin-1
Prevalence
Risk Factors
Statistics
Vascular dementia
India
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:As part of a larger epidemiological survey to study the prevalence of dementia in a suburb of Mumbai, Western India, we identified 78 cases with a Clinical Dementia Rating (CDR) ≥ 1.0. Of these, 49 Alzheimer's disease (AD) cases were analyzed for risk association with APOE E*4 allele at apolipoprotein E gene (APOE) and presenilin-1 (PS-1) intron-8 polymorphism and were compared with 100 age-and sex-matched nondemented controls. Genotype analysis confirmed the association of APOE E*4 allele with AD as has been reported by various studies. We report a low frequency of APOE E*4 allele, consistent with a low prevalence of AD in this study. Comparisons with other similar studies on APOE from India suggest common risk factors for AD in the Indian population, which is diverse in its ethnic and racial characteristics. The frequency for allele 1 at PS-1 intron-8 polymorphism is the highest among all studies reported. This first report of PS-1 intron-8 polymorphism and AD from India demonstrates no significant association.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0018-7143
1534-6617
1534-6617
DOI:10.1353/hub.2002.0051