Search Results - "SRIDAR, Chitra"

Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase complex by Zhang, Haoming, Sridar, Chitra, Kenaan, Cesar, Amunugama, Hemali, Ballou, David P, Hollenberg, Paul F

“…In this study, metabolism of bupropion, efavirenz, and 7-ethoxy-4-trifluoromethylcoumarin (7-EFC) by CYP2B6 wild type (CYP2B6.1) and six polymorphic variants…”
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The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation by Yoshigae, Yasushi, Sridar, Chitra, Kent, Ute M, Hollenberg, Paul F

“…Phenethylisothiocyanate (PEITC), a naturally occurring isothiocyanate and potent cancer chemopreventive agent, works by multiple mechanisms, including the…”
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Inhibition of bupropion metabolism by selegiline: mechanism-based inactivation of human CYP2B6 and characterization of glutathione and peptide adducts by Sridar, Chitra, Kenaan, Cesar, Hollenberg, Paul F

“…Selegiline, the R-enantiomer of deprenyl, is used in the treatment of Parkinson's disease. Bupropion, an antidepressant, often used to treat patients in…”
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SILYBIN INACTIVATES CYTOCHROMES P450 3A4 AND 2C9 AND INHIBITS MAJOR HEPATIC GLUCURONOSYLTRANSFERASES by SRIDAR, Chitra, GOOSEN, Theunis C, KENT, Ute M, WILLIAMS, J. Andrew, HOLLENBERG, Paul F

“…Silybin, a major constituent of the milk thistle, is used to treat several liver disorders. Silybin inactivated purified, recombinant cytochromes P450 (P450)…”
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The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6 by Snider, Natasha T, Sikora, Matthew J, Sridar, Chitra, Feuerstein, Thomas J, Rae, James M, Hollenberg, Paul F

“…Members of the cytochrome P450 (P450) family of drug-metabolizing enzymes are present in the human brain, and they may have important roles in the oxidation of…”
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Differential Inhibition of Cytochromes P450 3A4 and 3A5 by the Newly Synthesized Coumarin Derivatives 7-Coumarin Propargyl Ether and 7-(4-Trifluoromethyl)coumarin Propargyl Ether by SRIDAR, Chitra, KENT, Ute M, NOON, Kate, MCCALL, Alecia, ALWORTH, Bill, FOROOZESH, Maryam, HOLLENBERG, Paul F

“…The abilities of 7-coumarin propargyl ether (CPE) and 7-(4-trifluoromethyl)coumarin propargyl ether (TFCPE) to act as mechanism-based inactivators of P450 3A4…”
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THE NATURALLY OCCURRING CYTOCHROME P450 (P450) 2B6 K262R MUTANT OF P450 2B6 EXHIBITS ALTERATIONS IN SUBSTRATE METABOLISM AND INACTIVATION by BUMPUS, Namandjé N, SRIDAR, Chitra, KENT, Ute M, HOLLENBERG, Paul F

“…The polymorphic human cytochrome P450 (P450) 2B6 is primarily responsible for the metabolism of several clinically relevant drugs including bupropion,…”
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Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6 by Sridar, Chitra, Kent, Ute M, Notley, Lisa M, Gillam, Elizabeth M J, Hollenberg, Paul F

“…Tamoxifen is primarily used in the treatment of breast cancer. It has been approved as a chemopreventive agent for individuals at high risk for this disease…”
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Identification of amino acid residues involved in the inactivation of cytochrome P450 2B1 by two acetylenic compounds: the role of three residues in nonsubstrate recognition Sites by Von Weymarn, Linda B, Sridar, Chitra, Hollenberg, Paul F

“…The homologous rat cytochrome P450s 2B1 and 2B2 differ by 13 amino acids. A chimeric construct of P450 2B1/2B2 was used in conjunction with several…”
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Synthesis of Substituted Phenyl Diaziridines and Characterization as Mechanism-Based Inactivators of Human Cytochrome P450 2B6 by SRIDAR, Chitra, KOBAYASHI, Yoshimasa, BREVIG, Holly, KENT, Ute M, PUPPALI, Satish G, RIMOLDI, John M, HOLLENBERG, Paul F

“…The metabolism of arylhydrazines by cytochromes P450 (P450s) has previously been shown to yield aryl-iron complexes that inhibit P450 enzymes as a result of…”
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Structure-Activity Relationship and Elucidation of the Determinant Factor(s) Responsible for the Mechanism-Based Inactivation of Cytochrome P450 2B6 by Substituted Phenyl Diaziridines by Kobayashi, Yoshimasa, Sridar, Chitra, Kent, Ute M, Puppali, Satish G, Rimoldi, John M, Zhang, Haoming, Waskell, Lucy, Hollenberg, Paul F

“…It has been demonstrated previously that several 3-trifluoromethyl-3-(4-alkoxyphenyl)diaziridines inhibit the 7-ethoxy-4-(trifluoroethyl)coumarin (7-EFC) O…”
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Bioactivation of the cancer chemopreventive agent tamoxifen to quinone methides by cytochrome P4502B6 and identification of the modified residue on the apoprotein by Sridar, Chitra, D'Agostino, Jaime, Hollenberg, Paul F

“…The nonsteroidal antiestrogen tamoxifen was introduced as a treatment for breast cancer 3 decades ago. It has also been approved as a chemopreventive agent and…”
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Anandamide Oxidation by Wild-Type and Polymorphically Expressed CYP2B6 and CYP2D6 by SRIDAR, Chitra, SNIDER, Natasha T, HOLLENBERG, Paul F

“…Anandamide is an arachidonic acid-derived endogenous cannabinoid that regulates normal physiological functions and pathophysiological responses within the…”
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Quantitation of UGT1A1 in human liver microsomes using stable isotope-labelled peptides and mass spectrometry based proteomic approaches by Sridar, Chitra, Hanna, Imad, Hollenberg, Paul F.

“…1. UDP-glucuronosyltransferases (UGTs) are a group of drug-metabolizing enzymes that catalyse the conjugation of endogeonous compounds and xenobiotics to yield…”
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Metabolism of Cyclophosphamide by the Human Cytochrome P450 2B6 Polymorphic Variants by Calinski, Diane, Zhang, Haoming, Sridar, Chitra, Hollenberg, Paul F.

“…Abstract only The alkylating agent, cyclophosphamide, is a common therapeutic agent used in the treatment of many cancers. Importantly, the efficacy and…”
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Anandamide Oxidation by Wild-Type and Polymorphically Expressed CYP2B6 and CYP2D6S by Sridar, Chitra, Snider, Natasha T., Hollenberg, Paul F.

“…Anandamide is an arachidonic acid-derived endogenous cannabinoid that regulates normal physiological functions and pathophysiological responses within the…”
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The endocannabinoid anandamide is a substrate of cytochrome P450 2D6 by Snider, Natasha Tasheva, Sridar, Chitra, Hollenberg, Paul

“…Abstract only The endocannabinoid anandamide, an arachidonic acid derivative, activates the cannabinoid receptors CB1 and CB2. These receptors and the enzymes…”
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Modification of Serine 360 by a Reactive Intermediate of 17-a-Ethynylestradiol Results in Mechanism-Based Inactivation of Cytochrome P450s 2B1 and 2B6 by Kent, Ute M, Sridar, Chitra, Spahlinger, Greg, Hollenberg, Paul F

“…17-*a-Ethynylestradiol (17EE) is a mechanism-based inactivator of P450 2B1 and P450 2B6 in the reconstituted monooxygenase system. The loss in enzymatic…”
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Modification of Serine 360 by a Reactive Intermediate of 17-α-Ethynylestradiol Results in Mechanism-Based Inactivation of Cytochrome P450s 2B1 and 2B6 by Kent, Ute M, Sridar, Chitra, Spahlinger, Greg, Hollenberg, Paul F

“…17-α-Ethynylestradiol (17EE) is a mechanism-based inactivator of P450 2B1 and P450 2B6 in the reconstituted monooxygenase system. The loss in enzymatic…”
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Modification of Serine 360 by a Reactive Intermediate of 17-α-Ethynylestradiol Leads to Mechanism-based Inactivation of Cytochrome P450s 2B1 and 2B6 by Kent, Ute M., Sridar, Chitra, Spahlinger, Greg, Hollenberg, Paul F.

“…17-α-Ethynylestradiole (17EE) is a mechanism-based inactivator of CYP 2B1 and CYP 2B6 in the reconstituted system. The loss in enzymatic activity was due to…”
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