Search Results - "SQUIRE, J. A"

Pan-cancer genomic analysis shows hemizygous PTEN loss tumors are associated with immune evasion and poor outcome by Vidotto, T., Melo, C. M., Lautert-Dutra, W., Chaves, L. P., Reis, R. B., Squire, J. A.

“…In tumors, somatic mutations of the PTEN suppressor gene are associated with advanced disease, chemotherapy resistance, and poor survival. PTEN loss of…”
Get full text

Fish analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome by YOSHIMOTO, M, CUNHA, I. W, COUDRY, R. A, FONSECA, F. P, TORRES, C. H, SOARES, F. A, SQUIRE, J. A

“…This study examines the clinical impact of PTEN genomic deletions using fluorescence in situ hybridisation (FISH) analysis of 107 prostate cancers, with…”
Get full text

Chromosome 6p amplification and cancer progression by Santos, Gda C, Zielenska, M, Prasad, M, Squire, J A

“…Chromosomal imbalances represent an important mechanism in cancer progression. A clear association between DNA copy-number aberrations and prognosis has been…”
Get full text

The Role of RUNX2 in Osteosarcoma Oncogenesis by van Wijnen, A. J., Zielenska, Maria, Stein, Gary S., Squire, Jeremy A., Martin, Jeff W.

“…Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents. Its rarity and biological heterogeneity have limited…”
Get full text

Amplification of telomerase ( ) gene is a poor prognostic marker in non-small-cell lung cancer by ZHU, C.-Q, CUTZ, J.-C, LIU, N, LAU, D, SHEPHERD, F. A, SQUIRE, J. A, TSAO, M.-S

“…Telomerase reactivation is a hallmark of human carcinogenesis. Increased telomerase activity may result from gene amplification and/or overexpression. This…”
Get full text

Breast cancer 1 (BRCA1) protein expression as a prognostic marker in sporadic epithelial ovarian carcinoma: an NCIC CTG OV.16 correlative study by Weberpals, J.I., Tu, D., Squire, J.A., Amin, M.S., Islam, S., Pelletier, L.B., O'Brien, A.M., Hoskins, P.J., Eisenhauer, E.A.

“…Breast cancer 1 (BRCA1) protein inactivation in sporadic ovarian carcinoma (OC) is common and low BRCA1 expression is linked with platinum sensitivity. The…”
Get full text

Topographical analysis of telomere length and correlation with genomic instability in whole mount prostatectomies by Joshua, A.M., Shen, E., Yoshimoto, M., Marrano, P., Zielenska, M., Evans, A.J., Van der Kwast, T., Squire, J.A.

“…BACKGROUND Many critical events in prostatic carcinogenesis appear to relate to the emergence of genomic instability. Characteristic genomic abnormalities such…”
Get full text

Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization, and spectral karyotyping by BAYANI, J, ZIELENSKA, M, MARRANO, P, YIM KWAN NG, TAYLOR, M. D, JAY, V, RUTKA, J. T, SQUIRE, J. A

“…Medulloblastomas and related primitive neuroectodermal tumors (PNETs) of the central nervous system are malignant, invasive embryonal tumors with predominantly…”
Get full text

Expression of TEL-JAK2 in Primary Human Hematopoietic Cells Drives Erythropoietin-Independent Erythropoiesis and Induces Myelofibrosis in vivo by Kennedy, J. A., Barabé, F., Patterson, B. J., Bayani, J., Squire, J. A., Barber, D. L., Dick, J. E.

“…Activation of JAK2 by chromosomal translocation or point mutation is a recurrent event in hematopoietic malignancies, including acute leukemias and…”
Get full text

Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH by Selvarajah, S, Yoshimoto, M, Ludkovski, O, Park, P C, Bayani, J, Thorner, P, Maire, G, Squire, J A, Zielenska, M

“…Osteosarcoma (OS) is characterized by an unstable karyotype which typically has a heterogeneous pattern of complex chromosomal abnormalities. High-resolution…”
Get more information

Correlating breakage-fusion-bridge events with the overall chromosomal instability and in vitro karyotype evolution in prostate cancer by Vukovic, B, Beheshti, B, Park, P, Lim, G, Bayani, J, Zielenska, M, Squire, J A

“…Chromosomal instability (CIN) is thought to underlie the generation of chromosomal changes and genomic heterogeneity during prostatic tumorigenesis. The…”
Get more information

Quantitative PCR identifies a minimal deleted region of 120 kb extending from the philadelphia chromosome ABL translocation breakpoint in chronic myeloid leukemia with poor outcome by KOLOMIETZ, E, MARRANO, P, SQUIRE, J. A, YEE, K, THAI, B, BRAUDE, I, KOLOMIETZ, A, CHUN, K, MINKIN, S, KAMEL-REID, S, MINDEN, M

“…Fluorescence in situ hybridization (FISH) analysis has shown previously that 10-15% of chronic myeloid leukemias (CML) have hemizygous deletions of variable…”
Get full text

A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer by Koti, M, Siu, A, Clément, I, Bidarimath, M, Turashvili, G, Edwards, A, Rahimi, K, Masson, A-M M, Squire, J A

“…Background: Chemotherapy resistance is a major determinant of poor overall survival rates in high-grade serous ovarian cancer (HGSC). We have previously shown…”
Get full text

Cause and Consequences of Genetic and Epigenetic Alterations in Human Cancer by Sadikovic, B, Al-Romaih, K, Squire, J A, Zielenska, M

“…Both genetic and epigenetic changes contribute to development of human cancer. Oncogenomics has primarily focused on understanding the genetic basis of…”
Get full text

Integrated cytogenetic and high-resolution array CGH analysis of genomic alterations associated with MYCN amplification by Pandita, A, Bayani, J, Paderova, J, Marrano, P, Graham, C, Barrett, M, Prasad, M, Zielenska, M, Squire, J A

“…Amplification of oncogenes and closely linked flanking genes is common in some types of cancer and can be associated with complex chromosome rearrangements…”
Get more information

Analysis of segmental duplications, mouse genome synteny and recurrent cancer-associated amplicons in human chromosome 6p21-p12 by Martin, J W, Yoshimoto, M, Ludkovski, O, Thorner, P S, Zielenska, M, Squire, J A, Nuin, P A S

“…It has been proposed that regions of microhomology in the human genome could facilitate genomic rearrangements, copy number transitions, and rapid genomic…”
Get more information

A phase II study of the HDAC inhibitor SB939 in patients with castration resistant prostate cancer: NCIC clinical trials group study IND195 by Eigl, B. J., North, S., Winquist, E., Finch, D., Wood, L., Sridhar, S. S., Powers, J., Good, J., Sharma, M., Squire, J. A., Bazov, J., Jamaspishvili, T., Cox, M. E., Bradbury, P. A., Eisenhauer, E. A., Chi, K. N.

“…Summary Background SB939 is a potent oral inhibitor of class 1, 2, and 4 histone deacetylases (HDACs). These three HDAC classes are highly expressed in…”
Get full text

A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer by Koti, M, Siu, A, Clément, I, Bidarimath, M, Turashvili, G, Edwards, A, Rahimi, K, Mes-Masson, A-M, Squire, J A

Get full text

Advances in the detection of chromosomal aberrations using spectral karyotyping by Bayani, J, Squire, JA

“…Spectral karyotyping (SKY) is a powerful 24‐color, whole chromosome‐painting assay allowing the visualization of each chromosome in one experiment. Subtle…”
Get full text

Frequent monoallelic loss of D13S319 in multiple myeloma patients shown by interphase fluorescence in situ hybridization by CHANG, H, BOUMAN, D, BOERKOEL, C. F, STEWART, A. K, SQUIRE, J. A

“…Deletions or monosomy of chromosome 13 are frequent in multiple myeloma (MM). A candidate tumor suppressor gene might reside telomeric of the retinoblastoma…”
Get full text