Search Results - "SQUINTO, S. P"

A BDNF autocrine loop in adult sensory neurons prevents cell death by Acheson, Ann, Conover, Joanne C, Fandl, James P, DeChiara, Thomas M, Russell, Michelle, Thadani, Anu, Squinto, Stephen P, Yancopoulos, George D, Lindsay, Ronald M

“…During the initial phase of their development, sensory neurons of the dorsal root ganglion (DRG) require target-derived trophic support for their survival, but…”
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Mammalian Neurotrophin-4: Structure, Chromosomal Localization, Tissue Distribution, and Receptor Specificity by Ip, Nancy Y., Ibanez, Carlos F., Nye, Steven H., McClain, Joyce, Jones, Pamela F., Gies, David R., Belluscio, Leonardo, Le Beau, Michelle M., Espinosa, Rafael, Squinto, Stephen P., Persson, Hakan, Yancopoulos, George D.

“…Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals…”
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BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra by Hyman, Carolyn, Hofer, Magdalena, Barde, Yves-Alain, Juhasz, Melissa, Yancopoulos, George D, Squinto, Stephen P, Lindsay, Ronald M

“…Brain-derived neurotrophic factor (BDNF), present in minute amounts in the adult central nervous system, is a member of the nerve growth factor (NGF) family,…”
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Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection by Fodor, W L, Williams, B L, Matis, L A, Madri, J A, Rollins, S A, Knight, J W, Velander, W, Squinto, S P

“…The serious shortage of human organs available for transplantation has engendered a heightened interest in the use of animal organs (xenografts) for…”
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Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation by Rinder, C S, Rinder, H M, Smith, B R, Fitch, J C, Smith, M J, Tracey, J B, Matis, L A, Squinto, S P, Rollins, S A

“…Complement activation contributes to the systemic inflammatory response induced by cardiopulmonary bypass. At the cellular level, cardiopulmonary bypass…”
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The Receptor for Ciliary Neurotrophic Factor by Davis, Samuel, Aldrich, Thomas H., Valenzuela, David M., Wong, Vivien, Furth, Mark E., Squinto, Stephen P., Yancopoulos, George D.

“…Although neurotrophic factors were originally isolated on the basis of their ability to support the survival of neurons, these molecules are now thought to…”
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trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor by Squinto, Stephen P, Stitt, Trevor N, Aldrich, Thomas H, Davis, Samuel, Blanco, Stella M, RadzieJewski, Czeslaw, Glass, David J, Masiakowski, Piotr, Furth, Mark E, Valenzuela, David M, Distefano, Peter S, Yancopoulos, George D

“…A variety of findings seem to functionally link brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), while distinguishing both of these factors…”
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A novel mechanism of retrovirus inactivation in human serum mediated by anti-alpha-galactosyl natural antibody by Rother, R P, Fodor, W L, Springhorn, J P, Birks, C W, Setter, E, Sandrin, M S, Squinto, S P, Rollins, S A

“…Type C retroviruses endogenous to various nonprimate species can infect human cells in vitro, yet the transmission of these viruses to humans is restricted…”
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TrkB mediates BDNF/NT-3-dependent survival and proliferation in fibroblasts lacking the low affinity NGF receptor by Glass, David J, Nye, Steven H, Hantzopoulos, Petros, Macchi, Mary J, Squinto, Stephen P, Goldfarb, Mitchell, Yancopoulos, George D

“…The neurotrophins (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], neurotrophin-3 [NT-3], and neurotrophin-4 [NT-4] ) have been defined by…”
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Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle by Helgren, Maureen E, Squinto, Stephen P, Davis, Heather L, Parry, David J, Boulton, Teri G, Heck, Carol S, Zhu, Yuan, Yancopoulos, George D, Lindsay, Ronald M, DiStefano, Peter S

“…The actions and receptor for ciliary neurotrophic factor (CNTF) are largely restricted to cells of the nervous system, although one of the CNTF receptor…”
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Inhibition of complement-mediated cytolysis by the terminal complement inhibitor of herpesvirus saimiri by ROTHER, R. P, ROLLINS, S. A, FODOR, W. L, ALBRECHT, J.-C, SETTER, E, FLECKENSTEIN, B, SQUINTO, S. P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Expression of human CD59 in transgenic pig organs enhances organ survival in an ex vivo xenogeneic perfusion model by KROSHUS, T. J, BOLMAN, R. M, DALMASSO, A. P, ROLLINS, S. A, GUILMETTE, E. R, WILLIAMS, B. L, SQUINTO, S. P, FODOR, W. L

“…The serious shortage of available donor organs for patients with end stage organ failure who are in need of solid organ transplantation has led to a heightened…”
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K-252a and staurosporine selectively block autophosphorylation of neurotrophin receptors and neurotrophin-mediated responses by Nye, S H, Squinto, S P, Glass, D J, Stitt, T N, Hantzopoulos, P, Macchi, M J, Lindsay, N S, Ip, N Y, Yancopoulos, G D

“…The same receptor tyrosine kinase (RTK) can mediate strikingly different biological responses in a fibroblast as opposed to a neuron. We have compared the…”
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Complement inhibition with an anti-C5 monoclonal antibody prevents acute cardiac tissue injury in an ex vivo model of pig-to-human xenotransplantation by Kroshus, T J, Rollins, S A, Dalmasso, A P, Elliott, E A, Matis, L A, Squinto, S P, Bolman, 3rd, R M

“…Prevention of hyperacute xenograft rejection in the pig-to-primate combination has been accomplished by removal of natural antibodies, complement depletion…”
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The complement control protein homolog of herpesvirus saimiri regulates serum complement by inhibiting C3 convertase activity by Fodor, W L, Rollins, S A, Bianco-Caron, S, Rother, R P, Guilmette, E R, Burton, W V, Albrecht, J C, Fleckenstein, B, Squinto, S P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Platelet-activating factor stimulates a fos/jun/AP-1 transcriptional signaling system in human neuroblastoma cells by Squinto, S P, Block, A L, Braquet, P, Bazan, N G

“…Platelet-activating factor (PAF) elicits a rapid and transient activation of the proto-oncogenes c-fos and c-jun in SH-SY5Y neuroblastoma cells, but only to a…”
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Morphine activation of c-fos expression in rat brain by Chang, S L, Squinto, S P, Harlan, R E

“…The post-receptor mechanism of opiate action has been studied by examining the activation by morphine of the proto-oncogene c-fos and its encoded nucleoprotein…”
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Platelet‐activating factor and polyunsaturated fatty acids in cerebral ischemia or convulsions: Intracellular PAF‐binding sites and activation of a fos/jun/AP‐1 transcriptional signaling system by Bazan, Nicolas G., Squinto, Stephen P., Braquet, Pierre, Panetta, Thomas, Marcheselli, Victor L.

“…Platelet‐activating factor (PAF) is a lipid mediator formed in the early response of the central nervous system to ischemia or convulsions. Free…”
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Rapid expression of an anti-human C5 chimeric Fab utilizing a vector that replicates in COS and 293 cells by Evans, Mark J., Hartman, Sandra L., Wolff, Dennis W., Rollins, Scott A., Squinto, Stephen P.

“…Inhibition of complement system activation requires the development of soluble nonimmunogenic inhibitors with good tissue penetrating abilities that are…”
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Protection of porcine aortic endothelial cells from complement-mediated cell lysis and activation by recombinant human CD59 by Kennedy, S P, Rollins, S A, Burton, W V, Sims, P J, Bothwell, A L, Squinto, S P, Zavoico, G B

“…Discordant xenogeneic organ transplantation is a potential solution to the critical shortage of suitable donor organs. However, clinical application of…”
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