Search Results - "SPURLINO, J"

The 2.3-A resolution structure of the maltose- or maltodextrin-binding protein, a primary receptor of bacterial active transport and chemotaxis by Spurlino, J C, Lu, G Y, Quiocho, F A

“…The three-dimensional structure of the maltose- or maltodextrin-binding protein (Mr = 40,622) with bound maltose has been obtained by crystallographic analysis…”
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Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis by Sharff, Andrew J, Rodseth, Lynn E, Spurlino, John C, Quiocho, Florante A

“…The periplasmic maltodextrin binding protein of Escherichia coli serves as an initial receptor for the active transport of and chemotaxis toward…”
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Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor by Quiocho, Florante A, Spurlino, John C, Rodseth, Lynn E

“…Background: Active-transport processes perform a vital function in the life of a cell, maintaining cell homeostasis and allowing access of nutrients…”
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1.56 A structure of mature truncated human fibroblast collagenase by Spurlino, J C, Smallwood, A M, Carlton, D D, Banks, T M, Vavra, K J, Johnson, J S, Cook, E R, Falvo, J, Wahl, R C, Pulvino, T A

“…The X-ray crystal structure of a 19 kDa active fragment of human fibroblast collagenase has been determined by the multiple isomorphous replacement method and…”
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Structural Analysis of Thrombin Complexed with Potent Inhibitors Incorporating a Phenyl Group as a Peptide Mimetic and Aminopyridines as Guanidine Substitutes by Bone, Roger, Lu, Tianbao, Illig, Carl R, Soll, Richard M, Spurlino, John C

“…The structure of the noncovalent complex of human α-thrombin with a nonpeptide inhibitor containing a central phenyl scaffold,…”
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Structure of human neutrophil collagenase reveals large S1′ specificity pocket by Stams, Travis, Spurlino, John C, Smith, Douglas L, Wahl, Robert C, Ho, Thau F, Qoronfleh, M. Walid, Banks, Tracey M, Rubin, Byron

“…The crystal structure of the catalytic domain of human neutrophil collagenase complexed with a peptide transition state analogue has been determined to a…”
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Inhibition of Matrix Metalloproteinases by Hydroxamates Containing Heteroatom-Based Modifications of the P1' Group by Gowravaram, Madhusudhan R, Johnson, Jeffrey S, Delecki, Daniel, Cook, Ewell R, Tomczuk, Bruce E, Ghose, Arup K, Mathiowetz, Alan M, Spurlino, John C, Rubin, Byron, Smith, Douglas L, Pulvino, Tricia, Wahl, Robert C

“…In this study, structure-based drug design of matrix metalloproteinase inhibitors [human fibroblast collagenase (HFC), human fibroblast stromelysin (HFS), and…”
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Atomic interactions in protein-carbohydrate complexes. Tryptophan residues in the periplasmic maltodextrin receptor for active transport and chemotaxis by Spurlino, J C, Rodseth, L E, Quiocho, F A

“…We have refined the 1.9 A resolution crystal structures of two maltodextrin receptor mutants in which tryptophan residues 230 and 232 have been changed to…”
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Genetic approach to the role of tryptophan residues in the activities and fluorescence of a bacterial periplasmic maltose-binding protein by Martineau, P, Szmelcman, S, Spurlino, J C, Quiocho, F A, Hofnung, M

“…The periplasmic maltose-binding protein (MBP or MalE protein) of Escherichia coli is an essential element in the transport of maltose and maltodextrins and in…”
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Proposed mechanisms for binding of apo[a] kringle type 9 to apo B-100 in human lipoprotein[a] by Guevara, J., Spurlino, J., Jan, A.Y., Yang, C.Y., Tulinsky, A., Prasad, B.V., Gaubatz, J.W., Morrisett, J.D.

“…The protein component of human lipoprotein[a] consists primarily of two apolipoproteins, apo[a] and apo B-100, linked through a cystine disulfide(s). In the…”
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Progress in the identification of interaction sites on the periplasmic maltose binding protein from E coli by Martineau, P, Saurin, W, Hofnung, M, Spurlino, J C, Quiocho, F A

“…The periplasmic maltose binding protein (MBP) is required for the high affinity transport of maltose and maltodextrins and for chemotaxis towards these sugars…”
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Acetylcholine Receptor-α-Bungarotoxin Interactions: Determination of the Region-to-Region Contacts by Peptide-Peptide Interactions and Molecular Modeling of the Receptor Cavity by Ruan, Ke-He, Spurlino, John, Quiocho, Florante A., Atassi, M. Zouhair

“…In previous studies from this laboratory, the binding regions of α-neurotoxins on human and Torpedo acetylcholine (AcCho) receptors (AcChoRs) and the binding…”
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Synthesis of thiophene-2-carboxamidines containing 2-aminothiazoles and their biological evaluation as urokinase inhibitors by WILSON, Kenneth J, ILLIG, Carl R, ZHANG, Marie, LEWANDOWSKI, Frank A, ZHAO ZHOU, SHARP, Celia, MAGUIRE, Diane, GRASBERGER, Bruce, DESJARLAIS, Renee L, SPURLINO, John, SUBASINGHE, Nalin, HOFFMAN, James B, RUDOLPH, M. Jonathan, SOLL, Richard, MOLLOY, Christopher J, BONE, Roger, GREEN, David, RANDALL, Troy

“…The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis…”
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Synthesis of thiophene-2-carboxamidines containing 2-amino-thiazoles and their biological evaluation as urokinase inhibitors by Wilson, Kenneth J., Illig, Carl R., Subasinghe, Nalin, Hoffman, James B., Jonathan Rudolph, M., Soll, Richard, Molloy, Christopher J., Bone, Roger, Green, David, Randall, Troy, Zhang, Marie, Lewandowski, Frank A., Zhou, Zhao, Sharp, Celia, Maguire, Diane, Grasberger, Bruce, DesJarlais, Renee L., Spurlino, John

“…The serine protease urokinase (uPa) has been implicated in the progression of both breast and prostate cancer. Utilizing structure based design, the synthesis…”
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Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis by TIANBAO LU, MARKOTAN, Thomas, BONE, Roger, COPPO, Frank, TOMCZUK, Bruce, CRYSLER, Carl, EISENNAGEL, Stephen, SPURLINO, John, GREMMINGER, Lisa, SOLL, Richard M, GIARDINO, Edward C

“…Through structure-based drug design and parallel synthesis, we have discovered a novel series of nonpeptidic phenyl-based thrombin inhibitors using…”
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Serendipity meets precision: the integration of structure-based drug design and combinatorial chemistry for efficient drug discovery by Salemme, F Raymond, Spurlino, John, Bone, Roger

“…Structure-based drug design uses three-dimensional visualization of drug candidates bound to a target receptor to direct structural modifications that increase…”
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Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells by Grasberger, Bruce L, Lu, Tianbao, Schubert, Carsten, Parks, Daniel J, Carver, Theodore E, Koblish, Holly K, Cummings, Maxwell D, LaFrance, Louis V, Milkiewicz, Karen L, Calvo, Raul R, Maguire, Diane, Lattanze, Jennifer, Franks, Carol F, Zhao, Shuyuan, Ramachandren, Kannan, Bylebyl, Gwendolyn R, Zhang, Marie, Manthey, Carl L, Petrella, Eugene C, Pantoliano, Michael W, Deckman, Ingrid C, Spurlino, John C, Maroney, Anna C, Tomczuk, Bruce E, Molloy, Christopher J, Bone, Roger F

“…HDM2 binds to an α-helical transactivation domain of p53, inhibiting its tumor suppressive functions. A miniaturized thermal denaturation assay was used to…”
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Oxyguanidines: application to non-peptidic phenyl-based thrombin inhibitors by Tomczuk, Bruce, Lu, Tianbao, Soll, Richard M, Fedde, Cynthia, Wang, Aihua, Murphy, Larry, Crysler, Carl, Dasgupta, Malini, Eisennagel, Stephen, Spurlino, John, Bone, Roger

“…Although thrombin has been extensively researched with many examples of potent and selective inhibitors, the key characteristics of oral bioavailability and…”
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Amidinohydrazones as guanidine bioisosteres : Application to a new class of potent, selective and orally bioavailable, non-amide-based small-molecule thrombin inhibitors by SOLL, R. M, LU, T, TOMCZUK, B, ILLIG, C. R, FEDDE, C, EISENNAGEL, S, BONE, R, MURPHY, L, SPURLINO, J, SALEMME, F. R

“…We describe a new class of potent, non-amide-based small molecule thrombin inhibitors in which an amidinohydrazone is used as a guanidine bioisostere on a…”
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In vitro evaluation and crystallographic analysis of a new class of selective, non-amide-based thrombin inhibitors by Lu, Tianbao, Tomczuk, Bruce, Illig, Carl R., Bone, Roger, Murphy, Larry, Spurlino, John, Salemme, F.Raymond, Soll, Richard M.

“…We describe the in vitro evaluation and crystallographic analysis of a new class of potent and selective, non-aminoacid-based, small-molecule thrombin…”
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