Search Results - "SPRUCE, B. A"

HIF-1α contributes to tumour-selective killing by the sigma receptor antagonist rimcazole by ACHISON, M, BOYLAN, M. T, HUPP, T. R, SPRUCE, B. A

“…We have previously reported tumour-selective killing by the sigma (σ) receptor ligand rimcazole. We now report that rimcazole elevates hypoxia inducible…”
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Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-κB- and p53-regulated gene targets by McTavish, N, Copeland, L A, Saville, M K, Perkins, N D, Spruce, B A

“…The respective pro- and antiapoptotic functions of the transcription factors p53 and nuclear factor Kappa B (NF- Kappa B), and their potential impact on…”
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The trigger to cell death determines the efficiency with which dying cells are cleared by neighbours by Wiegand, U K, Corbach, S, Prescott, A R, Savill, J, Spruce, B A

“…Phagocytosis of apoptotic cells is required to prevent tissue injury. Professional phagocytes, such as monocyte-derived macrophages, are highly efficient…”
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polo encodes a protein kinase homolog required for mitosis in Drosophila by LLAMAZARES, S, MOREIRA, A, TAVARES, A, GIRDHAM, C, SPRUCE, B. A, GONZALEZ, C, KARESS, R. E, GLOVER, D. M, SUNKEL, C. E

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A neuropeptide precursor in cerebellum: proenkephalin exists in subpopulations of both neurons and astrocytes by Spruce, B.A., Curtis, R., Wilkin, G.P., Glover, D.M.

“…The adult rat cerebellum has minimal enkephalin immunoreactivity and is devoid of opiate‐binding activity. Using novel monoclonal antibodies to the mammalian…”
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The effect of vasopressin infusion on glucose metabolism in man by Spruce, B A, McCulloch, A J, Burd, J, Orskov, H, Heaton, A, Baylis, P H, Alberti, K G

“…Studies on intact animals and isolated rat hepatocytes have shown that arginine vasopression (AVP) stimulates glycogen phosphorylase to break down glycogen and…”
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Monoclonal antibodies to a proenkephalin A fusion peptide synthesized in Escherichia coli recognize novel proenkephalin A precursor forms by Spruce, B A, Jackson, S, Lowry, P J, Lane, D P, Glover, D M

“…Monoclonal antibodies have been generated to a chimeric peptide comprised of Escherichia coli beta-galactosidase fused to the amino acid sequence 69-207 of…”
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Variation in osmoregulation of arginine vasopressin during the human menstrual cycle by Spruce, B A, Baylis, P H, Burd, J, Watson, M J

“…Osmoregulation of vasopressin secretion was studied in eight healthy women in the follicular and luteal phases of the menstrual cycle. Basal plasma osmolality…”
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polo encodes a protein kinase homolog required for mitosis in Drosophila by Llamazares, S, Moreira, A, Tavares, A, Girdham, C, Spruce, B A, Gonzalez, C, Karess, R E, Glover, D M, Sunkel, C E

“…We show that mutation in polo leads to a variety of abnormal mitoses in Drosophila larval neuroblasts. These include otherwise normal looking mitotic spindles…”
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Identification of high molecular weight peptides in bovine adrenomedullary chromaffin granules using monoclonal antibodies to a preproenkephalin A fusion peptide by Jackson, S, Spruce, B A, Glover, D M, Glynn, B P, Lowry, P J

“…Two mouse monoclonal antibodies (PE-1 and PE-2) raised to a beta-galactosidase-preproenkephalin A(69-207) fusion peptide recognize pro-enkephalin A (pro-enk-A)…”
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Endogenous opioids and oligodendroglial function: Possible autocrine/paracrine effects on cell survival and development by Knapp, Pamela E., Itkis, Olga S., Zhang, Lixin, Spruce, Barbara A., Bakalkin, Georgy, Hauser, Kurt F.

“…Previous work has shown that oligodendrocytes (OLs) express both μ‐ and κ‐opioid receptors. In developing OLs, μ receptor activation increases OL…”
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Ontogeny of proenkephalin mRNA and enkephalin peptide expression in the cerebellar cortex of the rat: spatial and temporal patterns of expression follow maturational gradients in the external granular layer and in Purkinje cells by Osborne, J G, Kindy, M S, Spruce, B A, Hauser, K F

“…Proenkephalin mRNA and peptide products were examined in developing cells of the postnatal rat cerebellar cortex using in situ hybridization and…”
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Proenkephalin Is a Nuclear Protein Responsive to Growth Arrest and Differentiation Signals by Böttger, Angelika, Spruce, Barbara A.

“…Neuropeptide precursors are traditionally viewed as molecules destined to be cleaved into bioactive peptides, which are then released from the cell to act on…”
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The effect of bromocriptine in the polycystic ovary syndrome by Spruce, B A, Kendall-Taylor, P, Dunlop, W, Anderson, A J, Watson, M J, Cook, D B, Gray, C

“…The effect of chronic administration of bromocriptine to 20 patients with the polycystic ovary syndrome (PCOS) was studied. All patients had normal serum…”
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The regulation of vasopressin secretion in a patient with oat cell carcinoma of the bronchus by Spruce, B. A., Baylis, P. H.

“…We report a patient who had an oat cell bronchogenic carcinoma in association with the syndrome of inappropriate antidiuresis. There was an unusually long…”
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Comprehensive epitope analysis of monoclonal anti-proenkephalin antibodies using phage display libraries and synthetic peptides: revelation of antibody fine specificities caused by somatic mutations in the variable region genes by Böttger, V, Böttger, A, Lane, E B, Spruce, B A

“…Filamentous phage libraries, displaying 6, 12 or 20 amino acid residue peptides at the N terminus of coat protein pIII were used to define and localize the…”
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A solid phase radioimmunoassay for human plasma arginine vasopressin by Burd, J, Weightman, D R, Spruce, B A, Baylis, P H

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Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF- B- and p53-regulated gene targets by McTavish, N, Copeland, L A, Saville, M K, Perkins, N D, Spruce, B A

“…The respective pro- and antiapoptotic functions of the transcription factors p53 and nuclear factor kappaB (NF-kappaB), and their potential impact on…”
Get full text

Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-kappaB- and p53-regulated gene targets by McTavish, N, Copeland, L A, Saville, M K, Perkins, N D, Spruce, B A

“…The respective pro- and antiapoptotic functions of the transcription factors p53 and nuclear factor kappaB (NF-kappaB), and their potential impact on…”
Get full text

HIF-1alpha contributes to tumour-selective killing by the sigma receptor antagonist rimcazole by Achison, M, Boylan, M T, Hupp, T R, Spruce, B A

“…We have previously reported tumour-selective killing by the sigma (sigma) receptor ligand rimcazole. We now report that rimcazole elevates hypoxia inducible…”
Get full text