Follow-up of collagen crosslink excretion in patients with oral squamous cell carcinoma and analysis of tissue samples

The presence of an oral squamous cell carcinoma (OSCC) may be associated with increased urinary excretion of the markers of collagen degradation, hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP). We investigated the possibility of these markers predicting the presence of active disease. Pati...

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Bibliographic Details
Published in:	British journal of cancer Vol. 89; no. 9; pp. 1722 - 1728
Main Authors:	SPRINPER, I. N. G, TERHEYDEN, H, SUHR, M. A. A, WARNKE, P, DUNSCHE, A, TIEMANN, M, ACIL, Y
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 03-11-2003
Subjects:	Adult Aged Aged, 80 and over Amino Acids - analysis Biological and medical sciences Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - urine Collagen - metabolism Disease Progression Female Humans Male Mandibular Neoplasms - secondary Medical sciences Middle Aged Molecular and Cellular Pathology Mouth Neoplasms - metabolism Mouth Neoplasms - urine Otorhinolaryngology. Stomatology Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Human Urine Squamous cell carcinoma Stomatology Diseases of the osteoarticular system Biological marker Resorption oral squamous cell carcinoma Malignant tumor pyndinoline Osteolysis tissue samples Oral cavity Crosslinked state Collagen Oral cavity disease collagen crosslinks Bone
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Summary:	The presence of an oral squamous cell carcinoma (OSCC) may be associated with increased urinary excretion of the markers of collagen degradation, hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP). We investigated the possibility of these markers predicting the presence of active disease. Patients from a current study on HP and LP were included as follows: Group 1a (OSCC with confirmed mandibular bony infiltration, n=12), group 1b (group 1a patients >6 months after successful treatment), group 2a (OSCC without evidence of mandibular bone infiltration, n=8), group 2b (group 2a patients >6 months after successful treatment), group 3a (recurrent OSCC, n=8), group 3b (group 3a patients >6 weeks later, symptoms unchanged) and group 4 (control group, n=74). Tissue samples from tumour tissue and adjacent healthy mucosa were additionally investigated for HP and LP concentrations (n=8). The decrease in the urinary concentrations of HP and LP was statistically significant between groups 1a and 1b (P<0.001 for HP and LP), but not between groups 2a and 2b (P=0.07 for HP and LP), while values in groups 1b and 2b were within the normal range. When comparing groups 3a and 3b, a significant increase was observed for LP (P=0.050), but not HP (P=0.208). In conclusion, successful treatment of OSCC with bony involvement may be associated with a reduction of urinary HP and LP, whereas ongoing disease may result in an increase of LP. HP and LP may both be useful markers of tumour progression in patients with OSCC.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-0920 1532-1827
DOI:	10.1038/sj.bjc.6601325