Search Results - "SPORN, M"

The war on cancer by Sporn, M B

“…25 years ago, then President Nixon "declared" War on Cancer. In this personal commentary, the war is reviewed. There have been obvious triumphs, for instance…”
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Fifteen-year results of a randomized phase III trial of fenretinide to prevent second breast cancer by Veronesi, U., Mariani, L., Decensi, A., Formelli, F., Camerini, T., Miceli, R., Di Mauro, M.G., Costa, A., Marubini, E., Sporn, M.B., De Palo, G.

“…Purpose: The synthetic retinoid fenretinide administered for 5 years for prevention of second breast cancer showed no difference after a median of 8 years, but…”
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Chemoprevention of cancer by Sporn, Michael B., Suh, Nanjoo

“…In this short article, we review the conceptual basis for chemoprevention of cancer, the proven clinical efficacy of this concept, and current trends to…”
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Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer by VERONESI, U, DE PALO, G, MURACA, M. G, DEL VECCHIO, M, PINTO, C, D'AIUTO, G, BONI, C, CAMPA, T, MAGNI, A, MICELI, R, PERLOFF, M, MALONE, W. F, MARUBINI, E, SPORN, M. B, COSTA, A, FORMELLI, F, MARIANI, L, DECENSI, A, CAMERINI, T, ROSSELLI DEL TURCO, M, DI MAURO, M. G

“…Fenretinide, a vitamin A analogue, has been shown to inhibit breast carcinogenesis in preclinical studies. We determined the efficacy of fenretinide in…”
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Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells by SUBBARAMAIAH, K, MICHALUART, P, SPORN, M. B, DANNENBERG, A. J

“…We investigated the effects of ursolic acid, a chemopreventive agent, on the expression of cyclooxygenase-2 (COX-2) in phorbol 12-myristate 13-acetate…”
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A new ligand for the peroxisome proliferator-activated receptor-γ (PPAR-γ), GW7845, inhibits rat mammary carcinogenesis by NANJOO SUH, YONGPING WANG, WILLIAMS, C. R, RISINGSONG, R, GILMER, T, WILLSON, T. M, SPORN, M. B

“…We have tested a new ligand for peroxisome proliferator-activated receptor-gamma, GW7845, as an inhibitor of experimental mammary carcinogenesis, using the…”
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Synthetic Oleanane and Ursane Triterpenoids with Modified Rings A and C:  A Series of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages by Honda, Tadashi, Rounds, BarbieAnn V, Bore, Lothar, Finlay, Heather J, Favaloro, Frank G, Suh, Nanjoo, Wang, Yongping, Sporn, Michael B, Gribble, Gordon W

“…We have designed and synthesized 16 new olean- and urs-1-en-3-one triterpenoids with various modified rings C as potential antiinflammatory and cancer…”
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Transforming Growth Factor-β: Recent Progress and New Challenges by Sporn, Michael B., Roberts, Anita B.

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Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages by NANJOO SUH, HONDA, T, FINLAY, H. J, BARCHOWSKY, A, WILLIAMS, C, BENOIT, N. E, XIE, Q.-W, NATHAN, C, GRIBBLE, G. W, SPORN, M. B

“…We have synthesized more than 80 novel triterpenoids, all derivatives of oleanolic and ursolic acid, as potential anti-inflammatory and chemopreventive agents…”
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Cytokines in Context by Nathan, Carl, Sporn, Michael

“…In the last ten years, an avalanche of new information has flattened much of the conceptual framework erected in the first three decades of cytokine research…”
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Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions by Sanderson, N, Factor, V, Nagy, P, Kopp, J, Kondaiah, P, Wakefield, L, Roberts, A B, Sporn, M B, Thorgeirsson, S S

“…Aberrant expression of transforming growth factor beta 1 (TGF-beta 1) has been implicated in a number of disease processes, particularly those involving…”
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Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis by Suh, N, Paul, S, Lee, H.J, Yoon, T, Shah, N, Son, A.I, Reddi, A.H, Medici, D, Sporn, M.B

“…Summary Novel methods for inducing chondrogenesis are critical for cartilage tissue engineering and regeneration. Here we show that the synthetic oleanane…”
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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death by Kulkarni, A B, Huh, C G, Becker, D, Geiser, A, Lyght, M, Flanders, K C, Roberts, A B, Sporn, M B, Ward, J M, Karlsson, S

“…To delineate specific developmental roles of transforming growth factor beta 1 (TGF-beta 1) we have disrupted its cognate gene in mouse embryonic stem cells by…”
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Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL by SUH, W-S, KIM, Y. S, SCHIMMER, A. D, KITADA, S, MINDEN, M, ANDREEFF, M, SUH, N, SPORN, M, REED, J. C

“…Acute myelogenous leukemia (AML) remains a deadly disease for most adult patients, due primarily to the emergence of chemoresistant cells. Defects in apoptosis…”
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Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages by Honda, Tadashi, Rounds, BarbieAnn V., Gribble, Gordon W., Suh, Nanjoo, Wang, Yongping, Sporn, Michael B.

“…New derivatives with electron-withdrawing substituents at the C-2 position of 3-oxoolean-1-en-28-oic acid were synthesized. Among them,…”
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Suppressor T Cells Generated by Oral Tolerization to Myelin Basic Protein Suppress both in vitro and in vivo Immune Responses by the Release of Transforming Growth Factor β after Antigen-Specific Triggering by Miller, Ariel, Lider, Ofer, Roberts, Anita B., Sporn, Michael B., Weiner, Howard L.

“…Oral administration of myelin basic protein (MBP) is an effective way of suppressing experimental autoimmune encephalomyelitis (EAE). We have previously shown…”
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A Synthetic Triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid (CDDO), Is a Ligand for the Peroxisome Proliferator-Activated Receptor γ by Wang, Yongping, Porter, Weston W, Suh, Nanjoo, Honda, Tadashi, Gribble, Gordon W, Leesnitzer, Lisa M, Plunket, Kelli D, Mangelsdorf, David J, Blanchard, Steven G, Willson, Timothy M, Sporn, Michael B

“…A novel synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), previously reported to have potent differentiating, antiproliferative,…”
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TGF-β: Regulation of extracellular matrix by Roberts, Anita B., McCune, Bryan K., Sporn, Michael B.

“…Extracellular matrix (ECM) is an important determinant of cellular behavior, regulating cellular adhesion, cellular migration, cellular proliferation, and…”
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Recent Advances in Chemoprevention of Cancer by Hong, Waun Ki, Sporn, Michael B.

“…Chemoprevention is the use of pharmacologic or natural agents that inhibit the development of invasive cancer either by blocking the DNA damage that initiates…”
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Transforming Growth Factor-β and the Initiation of Chondrogenesis and Osteogenesis in the Rat Femur by Joyce, Michael E., Roberts, Anita B., Sporn, Michael B., Bolander, Mark E.

“…We have investigated the ability of exogenous transforming growth factor-β (TGF-β) to induce osteogenesis and chondrogenesis, critical events in both bone…”
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