Search Results - "SPITZFADEN, Claus"

Type IIA topoisomerase inhibition by a new class of antibacterial agents by Giordano, Ilaria, Spitzfaden, Claus E, Jones, Emma, Theobald, Andrew J, Gorrec, Fabrice, Jones, Jo, Hann, Michael M, May, Earl W, Saunders, Martin R, Fosberry, Andrew, Chan, Pan F, Eggleston, Drake S, Hibbs, Martin, Brown, Kristin Koretke, Lewis, Ceri J, Bax, Benjamin D, Singh, Onkar, Pearson, Neil D, Wohlkonig, Alexandre, Hennessy, Alan, Gentry, Daniel R, Huang, Jianzhong, Shen, Carol, Gwynn, Michael N, Shillings, Anthony

“…Despite the success of genomics in identifying new essential bacterial genes, there is a lack of sustainable leads in antibacterial drug discovery to address…”
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Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin by Chan, Pan F., Srikannathasan, Velupillai, Huang, Jianzhong, Cui, Haifeng, Fosberry, Andrew P., Gu, Minghua, Hann, Michael M., Hibbs, Martin, Homes, Paul, Ingraham, Karen, Pizzollo, Jason, Shen, Carol, Shillings, Anthony J., Spitzfaden, Claus E., Tanner, Robert, Theobald, Andrew J., Stavenger, Robert A., Bax, Benjamin D., Gwynn, Michael N.

“…New antibacterials are needed to tackle antibiotic-resistant bacteria. Type IIA topoisomerases (topo2As), the targets of fluoroquinolones, regulate DNA…”
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Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients by Lekova, Eleonora, Zelek, Wioleta M., Gower, David, Spitzfaden, Claus, Osuch, Isabelle H., John-Morris, Elen, Stach, Lasse, Gormley, Darren, Sanderson, Andrew, Bridges, Angela, Wear, Elizabeth R., Petit-Frere, Sebastien, Burden, Michael N., Priest, Richard, Wattam, Trevor, Kitchen, Semra J., Feeney, Maria, Davis, Susannah, Morgan, B. Paul, Nichols, Eva-Maria

“…Myasthenia Gravis (MG) is mediated by autoantibodies against acetylcholine receptors that cause loss of the receptors in the neuromuscular junction…”
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Structural Requirements for Biological Activity of the Ninth and Tenth FIII Domains of Human Fibronectin by Grant, Richard P., Spitzfaden, Claus, Altroff, Harri, Campbell, Iain D., Mardon, Helen J.

“…The ninth and tenth type III domains of fibronectin each contain specific cell binding sequences, RGD in FIII10 and PHSRN in FIII9, that act synergistically in…”
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A comparison of the folding kinetics and thermodynamics of two homologous fibronectin type III modules by Plaxco, Kevin W, Spitzfaden, Claus, Campbell, Iain D, Dobson, Christopher M

“…The homologous ninth and tenth type III modules of human fibronectin share identical topologies and nearly identical core structures. Despite these structural…”
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The structure of ribonuclease P protein from Staphylococcus aureus reveals a unique binding site for single-stranded RNA by Spitzfaden, Claus, Nicholson, Neville, Jones, Jo J, Guth, Sabine, Lehr, Ruth, Prescott, Cathy D, Hegg, Lisa A, Eggleston, Drake S

“…Ribonuclease P (RNaseP) catalyses the removal of the 5′-leader sequence from pre-tRNA to produce the mature 5′ terminus. The prokaryotic RNaseP holoenzyme…”
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Module-module interactions in the cell binding region of fibronectin: stability, flexibility and specificity by Spitzfaden, Claus, Grant, Richard P, Mardon, Helen J, Campbell, Iain D

“…The structure of mosaic proteins depends on the nature and strength of interactions between individual modules. Here we investigated the structural…”
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Destabilization of the complete protein secondary structure on binding to the chaperone GroEL by Zahn, Ralph, Spitzfaden, Claus, Ottiger, Marcel, Wüthrich, Kurt, Plückthun, Andreas

“…Protein folding in vivo is mediated by helper proteins, the molecular chaperones, of which Hsp60 and its Escherichia coli variant GroEL are some of the best…”
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Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy by Kallen, Jörg, Spitzfaden, Claus, Zurini, Mauro G. M, Wider, Gerhard, Widmer, Hans, Wüthrich, Kurt, Walkinshaw, Malcolm D

“…The protein cyclophilin is the major intracellular receptor for the immunosuppressive drug cyclosporin A. Cyclosporin A acts as an inhibitor of T-cell…”
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Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion by Agrawal, Alka, Roué, Mélanie, Spitzfaden, Claus, Petrella, Stéphanie, Aubry, Alexandra, Hann, Michael, Bax, Benjamin, Mayer, Claudine

“…DNA gyrase, a type II topoisomerase, regulates DNA topology by creating a double-stranded break in one DNA duplex and transporting another DNA duplex [T-DNA…”
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Cyclosporin A—cyclophilin complex formation A model based on X-ray and NMR data by Spitzfaden, Claus, Weber, Hans-Peter, Braun, Werner, Kallen, Joerg, Wider, Gerhard, Widmer, Hans, Walkinshaw, Malcolm D., Wüthrich, Kurt

“…The previously determined 3D NMR solution structure of cyclophilin-bound cyclosporin A (CsA) was docked onto the X-ray crystal structure of cyclophilin…”
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Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening by Borthwick, Jennifer A, Ancellin, Nicolas, Bertrand, Sophie M, Bingham, Ryan P, Carter, Paul S, Chung, Chun-wa, Churcher, Ian, Dodic, Nerina, Fournier, Charlène, Francis, Peter L, Hobbs, Andrew, Jamieson, Craig, Pickett, Stephen D, Smith, Sarah E, Somers, Donald O’N, Spitzfaden, Claus, Suckling, Colin J, Young, Robert J

“…Inhibitors of mitochondrial branched chain aminotransferase (BCATm), identified using fragment screening, are described. This was carried out using a…”
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The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits by Bertrand, Sophie M, Ancellin, Nicolas, Beaufils, Benjamin, Bingham, Ryan P, Borthwick, Jennifer A, Boullay, Anne-Bénédicte, Boursier, Eric, Carter, Paul S, Chung, Chun-wa, Churcher, Ian, Dodic, Nerina, Fouchet, Marie-Hélène, Fournier, Charlène, Francis, Peter L, Gummer, Laura A, Herry, Kenny, Hobbs, Andrew, Hobbs, Clare I, Homes, Paul, Jamieson, Craig, Nicodeme, Edwige, Pickett, Stephen D, Reid, Iain H, Simpson, Graham L, Sloan, Lisa A, Smith, Sarah E, Somers, Donald O’N, Spitzfaden, Claus, Suckling, Colin J, Valko, Klara, Washio, Yoshiaki, Young, Robert J

“…The hybridization of hits, identified by complementary fragment and high throughput screens, enabled the discovery of the first series of potent inhibitors of…”
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Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases by Miles, Timothy J., Hennessy, Alan J., Bax, Ben, Brooks, Gerald, Brown, Barry S., Brown, Pamela, Cailleau, Nathalie, Chen, Dongzhao, Dabbs, Steven, Davies, David T., Esken, Joel M., Giordano, Ilaria, Hoover, Jennifer L., Huang, Jianzhong, Jones, Graham E., Kusalakumari Sukmar, Senthill K., Spitzfaden, Claus, Markwell, Roger E., Minthorn, Elisabeth A., Rittenhouse, Steve, Gwynn, Michael N., Pearson, Neil D.

“…During the course of our research to find novel mode of action antibacterials, we discovered a series of hydroxyl tricyclic compounds that showed good potency…”
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Inhibitors of the DNA-cleavage gate of bacterial type IIA topoisomerases by Bax, Ben, Fosberry, Andrew, Spitzfaden, Claus, Shillings, Anthony, Pearson, Neil, Chan, Pan, Huang, Jianzhong

“…Abstract only Type IIA topoisomerases resolve topological problems in DNA by making a double-stranded break in one DNA segment, passing another DNA duplex…”
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Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide by Srikannathasan, Velupillai, Wohlkonig, Alexandre, Shillings, Anthony, Singh, Onkar, Chan, Pan F., Huang, Jianzhong, Gwynn, Michael N., Fosberry, Andrew P., Homes, Paul, Hibbs, Martin, Theobald, Andrew J., Spitzfaden, Claus, Bax, Benjamin D.

“…Fluoroquinolone drugs such as moxifloxacin kill bacteria by stabilizing the normally transient double‐stranded DNA breaks created by bacterial type IIA…”
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Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans by Howlett, D R, Perry, A E, Godfrey, F, Swatton, J E, Jennings, K H, Spitzfaden, C, Wadsworth, H, Wood, S J, Markwell, R E

“…A series of benzofuran derivatives have been identified as inhibitors of fibril formation in the beta-amyloid peptide. The activity of these compounds has been…”
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Building proteins with fibronectin type III modules by Campbell, I D, Spitzfaden, C

“…Fibronectin type III modules are versatile components of many proteins. Recent structures of module pairs show how these modules are joined together…”
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Rapid Refolding of a Proline-Rich all-$\beta $-sheet Fibronectin Type III Module by Plaxco, Kevin W., Spitzfaden, Claus, Campbell, Iain D., Dobson, Christopher M.

“…Fibronectin type III modules contain approximately 90 residues and are an extremely common building block of animal proteins. Despite containing a complex…”
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Structural studies on bacterial type IIA topoisomerases - targets for quinolone and coumarin antibiotics by Bax, Ben, Hibbs, Martin, Jones, Emma, Theobald, Andrew, Fosberry, Andrew, Spitzfaden, Claus, Shillings, Anthony, Wohlkonig, Alexandre, Koretke, Kristin K., Huang, Jianzhong, Pearson, Neil, Gwynn, Michael N.

“…Abstract only…”
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