Search Results - "SPINK, D. C"

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1 by Hayes, C L, Spink, D C, Spink, B C, Cao, J Q, Walker, N J, Sutter, T R

“…The 4-hydroxy metabolite of 17 beta-estradiol (E2) has been implicated in the carcinogenicity of this hormone. Previous studies showed that aryl…”
Get full text

Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells by SPINK, D. C, SPINK, B. C, CAO, J. Q, DEPASQUALE, J. A, PENTECOST, B. T, FASCO, M. J, YING LI, SUTTER, T. R

“…Human cytochromes P450 1A1 (CYP1A1) and P450 1B1 (CYP1B1) catalyze the metabolic activation of a number of procarcinogens and the hydroxylation of…”
Get full text

Multi-Vehicle Evaluation of Gasoline Additive Packages: A Fourth Generation Protocol for the Assessment of Intake System Deposit Removal by Spink, C. D., Coleman, A.T., Nelson, E. C., Wakefield, S., Shoffner, B. A.

“…Building on two decades of expertise, a fourth generation fleet test protocol is presented for assessing the response of engine performance to gasoline…”
Get full text

Induction of cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non- ortho-substituted polychlorinated biphenyls by Spink, B.C, Pang, S, Pentecost, B.T, Spink, D.C

“…The effects of 12 non- ortho-substituted polychlorinated biphenyl (PCB) congeners on the induction of human cytochrome P450 1B1 (CYP1B1), an estradiol…”
Get full text

The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on estrogen metabolism in MCF-7 breast cancer cells: evidence for induction of a novel 17 beta-estradiol 4-hydroxylase by Spink, D C, Hayes, C L, Young, N R, Christou, M, Sutter, T R, Jefcoate, C R, Gierthy, J F

“…Rates of microsomal 17 beta-estradiol (E2) hydroxylation at the C-2, -4, -6 alpha, and -15 alpha positions are each induced greater than 10-fold by treating…”
Get more information

Understanding the Human Health Effects of Chemical Mixtures by Carpenter, David O., Arcaro, Kathleen, Spink, David C.

“…Most research on the effects of chemicals on biologic systems is conducted on one chemical at a time. However, in the real world people are exposed to…”
Get full text

Inductive and inhibitory effects of non- ortho-substituted polychlorinated biphenyls on estrogen metabolism and human cytochromes P450 1A1 and 1B1 by Pang, Shaokun, Cao, Joan Q, Katz, Barbara H, Hayes, Carrie L, Sutter, Thomas R, Spink, David C

“…The effects of a series of non- ortho-substituted polychlorinated biphenyls (PCBs) on human cytochrome P450 1A1 (CYP1A1), a 17β-estradiol (E 2) 2-hydroxylase,…”
Get full text

2,3,7,8-Tetrachlorodibenzo-p-dioxin causes an extensive alteration of 17 beta-estradiol metabolism in MCF-7 breast tumor cells by D C Spink, D W Lincoln, 2nd, H W Dickerman, J F Gierthy

“…MCF-7 breast tumor cells form multicellular foci in vitro when supplemented with 17 beta-estradiol (E2). In the presence of E2 and the aryl…”
Get full text

Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN human renal adenocarcinoma cells by Spink, David C., Spink, Barbara C., Cao, Joan Q., Gierthy, John F., Hayes, Carrie L., Li, Ying, Sutter, Thomas R.

“…The catechol estrogen metabolites of 17β-estradiol (E 2), 2-hydroxyestradiol (OHE 2) and 4-OHE 2, differ in hormonal properties and carcinogenic potential. In…”
Get full text

Metabolic activation of 2,6-dichlorobenzonitrile, an olfactory-specific toxicant, by rat, rabbit, and human cytochromes P450 by Ding, X, Spink, D C, Bhama, J K, Sheng, J J, Vaz, A D, Coon, M J

“…The herbicide 2,6-dichlorobenzonitrile (DCBN) is known to cause tissue-specific toxicity at very low doses in the olfactory mucosa of rodents. The toxicity of…”
Get more information

Formation and structure of cross-linking and monomeric pyrrole autoxidation products in 2,5-hexanedione-treated amino acids, peptides, and protein by MINGSHE ZHU, SPINK, D. C, BIN YAN, BANK, S, DECAPRIO, A. P

“…2,5-Hexanedione (2,5-HD) is the neurotoxic gamma-diketone metabolite of the industrial solvent n-hexane. Substantial evidence indicates that 2,5-HD reacts with…”
Get full text

Estrogen regulates Ah responsiveness in MCF-7 breast cancer cells by Spink, David C., Katz, Barbara H., Hussain, Mirza M., Pentecost, Brian T., Cao, Zhimin, Spink, Barbara C.

“…Cytochrome P450 (CYP)1A1 and CYP1B1, which are under the regulatory control of the aryl hydrocarbon (Ah) receptor (AhR), catalyze the metabolic activation of…”
Get full text

Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice by Zhuo, X, Gu, J, Zhang, Q Y, Spink, D C, Kaminsky, L S, Ding, X

“…Coumarin was previously found to cause tissue-selective toxicity in the olfactory mucosa (OM) of rats and mice, with rats being the more sensitive species. The…”
Get more information

TCDD and PCBs inhibit breast cancer cell proliferation in vitro by Oenga, Gideon N., Spink, David C., Carpenter, David O.

“…The effects on cell proliferation of arylhydrocarbon receptor (AhR) agonists in estrogen-responsive T47D and ZR-75-1 cells were investigated…”
Get full text

Analysis of alkylpyrrole autoxidation products by high-performance liquid chromatography with thermospray mass spectrometry and UV photodiode-array detection by Zhu, M, Spink, D C, Bank, S, Chen, X, DeCaprio, A P

“…A method employing high-performance liquid chromatography with thermospray mass spectrometry (TSP-MS) and photodiode-array detection was developed and applied…”
Get more information

Kinetically different, multiple forms of glutamate decarboxylase in rat brain by Spink, D C, Porter, T G, Wu, S J, Martin, D L

“…Four molecular forms of rat-brain glutamate decarboxylase were resolved by hydrophobic interaction chromatography on phenyl-Sepharose and affinity…”
Get more information

Transaminations catalysed by brain glutamate decarboxylase by Porter, T G, Spink, D C, Martin, S B, Martin, D L

“…In addition to normal decarboxylation of glutamate to 4-aminobutyrate, glutamate decarboxylase from pig brain was shown to catalyse decarboxylation-dependent…”
Get full text

Characterization of isothiocyanates, thioureas, and other lysine adduction products in carbon disulfide-treated peptides and protein by DeCaprio, Anthony P, Spink, David C, Chen, Xi, Fowke, Jay H, Zhu, Mingshe, Bank, Shelton

“…Carbon disulfide (CS2) is an industrial solvent used in rayon production and as an organic synthetic precursor. It is also a member of the class of…”
Get full text

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1A1: a comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA by Spink, D C, Eugster, H P, Lincoln, 2nd, D W, Schuetz, J D, Schuetz, E G, Johnson, J A, Kaminsky, L S, Gierthy, J F

“…Exposure of MCF-7 breast cancer cells to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) causes an elevated cytochrome P450 content and a marked increase in the…”
Get more information

Analysis of aspartate and glutamate in human cerebrospinal fluid by high-performance liquid chromatography with automated precolumn derivatization by Spink, D C, Swann, J W, Snead, O C, Waniewski, R A, Martin, D L

“…A method is described for the analysis of the neuroexcitatory amino acids, aspartate and glutamate, in human cerebrospinal fluid (CSF) by reverse-phase,…”
Get more information