Search Results - "SPINK, B. C"

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1 by Hayes, C L, Spink, D C, Spink, B C, Cao, J Q, Walker, N J, Sutter, T R

“…The 4-hydroxy metabolite of 17 beta-estradiol (E2) has been implicated in the carcinogenicity of this hormone. Previous studies showed that aryl…”
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Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells by SPINK, D. C, SPINK, B. C, CAO, J. Q, DEPASQUALE, J. A, PENTECOST, B. T, FASCO, M. J, YING LI, SUTTER, T. R

“…Human cytochromes P450 1A1 (CYP1A1) and P450 1B1 (CYP1B1) catalyze the metabolic activation of a number of procarcinogens and the hydroxylation of…”
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Induction of cytochrome P450 1B1 in MDA-MB-231 human breast cancer cells by non- ortho-substituted polychlorinated biphenyls by Spink, B.C, Pang, S, Pentecost, B.T, Spink, D.C

“…The effects of 12 non- ortho-substituted polychlorinated biphenyl (PCB) congeners on the induction of human cytochrome P450 1B1 (CYP1B1), an estradiol…”
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SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells by Spink, Barbara C., Katz, Barbara H., Hussain, Mirza M., Pang, Shaokun, Connor, Steven P., Aldous, Kenneth M., Gierthy, John F., Spink, David C.

“…In a previous study of nine human breast-derived cell lines, rates of metabolism of 17β-estradiol (E2) were greatly enhanced when cultures were exposed to the…”
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Induction of cytochrome P450 1B1 and catechol estrogen metabolism in ACHN human renal adenocarcinoma cells by Spink, David C., Spink, Barbara C., Cao, Joan Q., Gierthy, John F., Hayes, Carrie L., Li, Ying, Sutter, Thomas R.

“…The catechol estrogen metabolites of 17β-estradiol (E 2), 2-hydroxyestradiol (OHE 2) and 4-OHE 2, differ in hormonal properties and carcinogenic potential. In…”
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Quantitation of CYP1A1 and 1B1 mRNA in polycyclic aromatic hydrocarbon-treated human T-47D and HepG2 cells by a modified bDNA assay using fluorescence detection by Wu, Susan J, Spink, David C, Spink, Barbara C, Kaminsky, Laurence S

“…The quantitation of mRNA, essential for assessing mechanisms of enzyme regulation, is normally carried out using reverse transcriptase–polymerase chain…”
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Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 12-O-tetradecanoylphorbol-13-acetate and 17β-estradiol on estrogen receptor regulation in MCF-7 human breast cancer cells by Gierthy, John F., Spink, Barbara C., Figge, Helen L., Pentecost, Brian T., Spink, David C.

“…2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD) exhibits remarkably potent antiestrogenic activity. To further elucidate the role of estrogen receptor (ER)…”
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Induction of CYP1A1 and CYP1B1 by benzo( k)fluoranthene and benzo( a)pyrene in T-47D human breast cancer cells: Roles of PAH interactions and PAH metabolites by Spink, David C., Wu, Susan J., Spink, Barbara C., Hussain, Mirza M., Vakharia, Dilip D., Pentecost, Brian T., Kaminsky, Laurence S.

“…The interactions of polycyclic aromatic hydrocarbons (PAH) and cytochromes P450 (CYP) are complex; PAHs are enzyme inducers, substrates, and inhibitors. In…”
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Growth inhibition of MCF-7 cells by estrogen is dependent upon a serum factor by Tanji, M, Katz, B H, Spink, B C, Carpenter, D O

“…MCF-7 cell growth is normally dependent upon estrogen, but if cells are maintained in serum-free medium estrogen inhibits cell growth with an IC50 of about 1…”
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Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells by Spink, Barbara C., Bennett, James A., Pentecost, Brian T., Lostritto, Nicole, Englert, Neal A., Benn, Geoffrey K., Goodenough, Angela K., Turesky, Robert J., Spink, David C.

“…The cumulative exposure to estrogens is an important determinant in the risk of breast cancer, yet the full range of mechanisms involving estrogens in the…”
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12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells by Spink, Barbara C., Fasco, Michael J., Gierthy, John F., Spink, David C.

“…Elevated expression of cytochrome P450 1B1 (CYP1B1) and estradiol 4‐hydroxylation have been reported to be biomarkers of tumorigenesis in humans. The aromatic…”
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Transient induction of cytochromes P450 1A1 and 1B1 in MCF-7 human breast cancer cells by indirubin by Spink, Barbara C., Hussain, Mirza M., Katz, Barbara H., Eisele, Leslie, Spink, David C.

“…The aryl hydrocarbon receptor (AhR), when activated by exogenous ligands such as 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), regulates expression of several…”
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Estrogen regulates Ah responsiveness in MCF-7 breast cancer cells by Spink, David C., Katz, Barbara H., Hussain, Mirza M., Pentecost, Brian T., Cao, Zhimin, Spink, Barbara C.

“…Cytochrome P450 (CYP)1A1 and CYP1B1, which are under the regulatory control of the aryl hydrocarbon (Ah) receptor (AhR), catalyze the metabolic activation of…”
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NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1 by Spink, D C, Spink, B C, Zhuo, X, Hussain, M M, Gierthy, J F, Ding, X

“…Human cytochrome P450 1B1 (CYP1B1) catalyzes the hydroxylation of 17beta-estradiol (E(2)) at C-4, with a lesser activity at C-2. The E(2) 4-hydroxylase…”
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Induction of CYP1A1 and CYP1B1 in T-47D Human Breast Cancer Cells by Benzo[a]pyrene Is Diminished by Arsenite by SPINK, David C, KATZ, Barbara H, HUSSAIN, Mirza M, SPINK, Barbara C, WU, Susan J, NING LIU, PAUSE, Ronald, KAMINSKY, Laurence S

“…Polycyclic aromatic hydrocarbons (PAHs) and metals are often environmental cocontaminants, yet there have been relatively few studies of combined effects of…”
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Inhibition of MCF-7 breast cancer cell proliferation by MCF-10A breast epithelial cells in coculture by Spink, Barbara C., Cole, Richard W., Katz, Barbara H., Gierthy, John F., Bradley, Laurie M., Spink, David C.

“…A coculture system was developed to investigate the interactions between MCF-10A breast epithelial cells and MCF-7 breast cancer cells stably expressing the…”
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